DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment jub and TRIP6

DIOPT Version :9

Sequence 1:	NP_572930.3	Gene:	jub / 32351	FlyBaseID:	FBgn0030530	Length:	728	Species:	Drosophila melanogaster
Sequence 2:	NP_003293.2	Gene:	TRIP6 / 7205	HGNCID:	12311	Length:	476	Species:	Homo sapiens

Alignment Length:	465	Identity:	153/465 - (32%)
Similarity:	214/465 - (46%)	Gaps:	102/465 - (21%)

- Green bases have known domain annotations that are detailed below.

  Fly   318 SPVPTAQSVAKLQQHTPV-----------KSPGG----------------------AINVSVNPN 349
            :|.|.....|.||.|..|           ::|||                      |....:.|.
Human    27 TPGPPPAHGAALQPHPRVNFCPLPSEQCYQAPGGPEDRGPAWVGSHGVLQHTQGLPADRGGLRPG 91

  Fly   350 YIE---DINSSDYVCMTANLHRNTAAGLATGRAAATGAPAQRTVQEPP---IITSSLAMGMATAA 408
            .::   |:.||            |.|.|..||..|:..|.::..:.||   ..|.||....|:..
Human    92 SLDAEIDLLSS------------TLAELNGGRGHASRRPDRQAYEPPPPPAYRTGSLKPNPASPL 144

  Fly   409 PPTTSNAPTSA----AAAPAAPTSTASLR-ATPIAMTAPLAVATSPTPSQGSTAVNAALK----- 463
            |.:....||.|    |:.||.|.....:: |.|:....|        |.:|::..:..|.
Human   145 PASPYGGPTPASYTTASTPAGPAFPVQVKVAQPVRGCGP--------PRRGASQASGPLPGPHFP 201

  Fly   464 -PRRGLTKNLLPYSVTPPRPAGPTEA-------------------------QRKIEELTRQLEEE 502
             |.||........|...|.|....||                         :.:::.||::|..:
Human   202 LPGRGEVWGPGYRSQREPGPGAKEEAAGVSGPAGRGRGGEHGPQVPLSQPPEDELDRLTKKLVHD 266

  Fly   503 IEQSEEHGEYFGICHTCGEKVKGAGQACQAMGNLYHTNCFICCSCGRALRGKAFYNVHGRVYCEE 567
            :..... |||||.|..|||.|.|.|....|:..::|..||:|.:|...|||:.||.|..|.|||.
Human   267 MNHPPS-GEYFGQCGGCGEDVVGDGAGVVALDRVFHVGCFVCSTCRAQLRGQHFYAVERRAYCEG 330

  Fly   568 DYMYSGFQQTAEKCAICGHLIMEMILQAMGKSYHPGCFRCCVCNECLDGVPFTVDVDHKIYCVND 632
            .|:     .|.||||.|...|::.||:||||:||||||.|.||:..|||:|||||...:|:|:.|
Human   331 CYV-----ATLEKCATCSQPILDRILRAMGKAYHPGCFTCVVCHRGLDGIPFTVDATSQIHCIED 390

  Fly   633 YHRMFAPKCASCGKGITPVEGTDETVRVVSMDKDFHVDCYICEECGMQLTDEPD-KRCYPLDGRL 696
            :||.|||:|:.||..|.|..|.:||||:|::|:.||:.||.|||||:.|:.|.: :.||||||.:
Human   391 FHRKFAPRCSVCGGAIMPEPGQEETVRIVALDRSFHIGCYKCEECGLLLSSEGECQGCYPLDGHI 455

  Fly   697 LCRGCHLQRL 706
            ||:.|...|:
Human   456 LCKACSAWRI 465

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
jub	NP_572930.3	LIM1_Ajuba_like	516..569	CDD:188738	23/52 (44%)
		LIM2_Ajuba_like	581..633	CDD:188741	29/51 (57%)
		LIM3_Ajuba_like	641..702	CDD:188822	31/61 (51%)
TRIP6	NP_003293.2	Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	1..93		12/65 (18%)
		Atrophin-1	<8..251	CDD:331285	50/243 (21%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	108..253		32/152 (21%)
		LIM1_TRIP6	279..332	CDD:188736	23/52 (44%)
		LIM	339..398	CDD:295319	34/58 (59%)
		LIM3_Zyxin_like	399..461	CDD:188743	31/61 (51%)
		Interaction with MAGI1 and PTPN13. /evidence=ECO:0000269\|PubMed:19017743	469..476
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_KOG1704
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	2	1.810