DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment jub and limd1

DIOPT Version :9

Sequence 1:	NP_572930.3	Gene:	jub / 32351	FlyBaseID:	FBgn0030530	Length:	728	Species:	Drosophila melanogaster
Sequence 2:	NP_001016606.1	Gene:	limd1 / 549360	XenbaseID:	XB-GENE-1017238	Length:	593	Species:	Xenopus tropicalis

Alignment Length:	672	Identity:	227/672 - (33%)
Similarity:	311/672 - (46%)	Gaps:	181/672 - (26%)

- Green bases have known domain annotations that are detailed below.

  Fly    81 QMQQLH-HNQDYKLYERGNIIAASK-----YATPRPVEQIQHTHNGSAQIYAPTAQILGQRIAPQ 139
            :|.::| .||...:.:.|.......     |:.|:.||::..|:||                  |
Frog    51 KMAKIHLQNQQKNIPDTGTSEGNGSNLQYTYSMPKSVEEVPVTYNG------------------Q 97

  Fly   140 KHSPVYENLEFYGQFDSNHKRAQPQSPGSRQSAILNGYLLMQPIRAGRFAHTPVPENQGSASLGT 204
            ..|.|       ||.|....|              ..|.:...|.:...:..||..::....|
Frog    98 SSSSV-------GQSDYKTYR--------------ESYKVKPEIDSADSSEEPVIRHEHEIML-- 139

  Fly   205 TRAAGGPPPPSGRSAALGPTGDLEEHAAPIYENIIPHSGQRAQPQASPATATMYQEMQPTSNSSG 269
                            |.|...: .||       ||......:...||:..::.:|...:.|...
Frog   140 ----------------LSPVSKV-GHA-------IPSQQFTCKKAISPSNESLERERIGSENMHS 180

  Fly   270 SSSTAGLDLNALLASPMHQRSISSNT---------ASSSSLGS------PTQRYRNLSLPSHLSP 319
                   |||  |:|.::.:.:..||         :||...|.      |.|::.|||.||.::.
Frog   181 -------DLN--LSSMINCKPMEKNTPHNKCSPLISSSVIFGEETNTHIPQQKFFNLSSPSSINL 236

  Fly   320 VPTAQSV----AKLQQHTPVKSPGGAINVSVNPNYIEDI--------------NSSDYV------ 360
            ..|:..|    .|..:....:..|.....|:|.....|:              ||||.:
Frog   237 QKTSDHVCLSETKAAKEFNGEQRGFCSTNSLNSGSSNDVKLSALSSYCVGYNENSSDQIKQMQAP 301

  Fly   361 CMTANLHRNTAAGLATGRAAATGAPAQRTVQEPPIITSSLAMGMATAAPPTTSNAPTSAAAAPAA 425
            |.|.|          :|.::|...|     ||.|.                   :.|.::|.|
Frog   302 CYTFN----------SGHSSADEQP-----QEIPF-------------------SCTDSSAEP-- 330

  Fly   426 PTSTASLRATPIAMTAPLAVATSPTPSQGSTAVNAALKPRRGLTKNLLP-YSVTPPRPAGPTEAQ 489
            |.||.......|       |..|.|                 |.|..|| .:::.....|.:.|:
Frog   331 PASTLDSDHIDI-------VQDSST-----------------LMKIKLPCQTLSQSSKQGSSRAE 371

  Fly   490 RKIEELTRQLEEEIEQSEEHGEYFGICHTCGEKVKGAGQACQAMGNLYHTNCFICCSCGRALRGK 554
            :|:|.:||.||:|:: :....:|||.|..|.:.|.||.|||||||||||..||||.:|.|.||||
Frog   372 KKLEAITRHLEQEMD-AHTRADYFGTCVKCSKGVYGANQACQAMGNLYHNGCFICSACSRKLRGK 435

  Fly   555 AFYNVHGRVYCEEDYMYSGFQQTAEKCAICGHLIMEMILQAMGKSYHPGCFRCCVCNECLDGVPF 619
            |||.|:|:||||||::||||.|:|::|.:|||.||:|||||:|||:|||||||.|||||||||||
Frog   436 AFYFVNGKVYCEEDFLYSGFHQSADRCFVCGHWIMDMILQALGKSFHPGCFRCAVCNECLDGVPF 500

  Fly   620 TVDVDHKIYCVNDYHRMFAPKCASCGKGITPVEGTDETVRVVSMDKDFHVDCYICEECGMQLTDE 684
            |||:::|||||.|||::.|||||:|...|.|.||||||:||||||||:|:|||.||.|.::|.:|
Frog   501 TVDMENKIYCVKDYHKILAPKCAACSLPILPSEGTDETIRVVSMDKDYHIDCYRCESCALELNNE 565

  Fly   685 PDKRCYPLDGRLLCRGCHLQRL 706
            .|.|||||:|.|.|..|||:.|
Frog   566 DDHRCYPLEGHLFCHNCHLKYL 587

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
jub	NP_572930.3	LIM1_Ajuba_like	516..569	CDD:188738	36/52 (69%)
		LIM2_Ajuba_like	581..633	CDD:188741	40/51 (78%)
		LIM3_Ajuba_like	641..702	CDD:188822	37/60 (62%)
limd1	NP_001016606.1	Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	308..336		12/53 (23%)
		LIM1_Ajuba_like	397..450	CDD:188738	36/52 (69%)
		LIM2_Ajuba_like	462..514	CDD:188741	40/51 (78%)
		LIM3_Ajuba_like	522..583	CDD:188822	37/60 (62%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	1	1.000	112	1.000	Domainoid score	I6129
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	1	1.000	-	-		FOG0004196
OrthoInspector	1	1.000	-	-		otm48518
Panther	1	1.100	-	-	LDO	PTHR24219
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	1	1.000	-	-		X3625
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	6	6.010