DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment jub and pdlim5

DIOPT Version :9

Sequence 1:	NP_572930.3	Gene:	jub / 32351	FlyBaseID:	FBgn0030530	Length:	728	Species:	Drosophila melanogaster
Sequence 2:	XP_012817118.2	Gene:	pdlim5 / 548530	XenbaseID:	XB-GENE-854114	Length:	884	Species:	Xenopus tropicalis

Alignment Length:	743	Identity:	153/743 - (20%)
Similarity:	266/743 - (35%)	Gaps:	177/743 - (23%)

- Green bases have known domain annotations that are detailed below.

  Fly    55 SYQRSPGAIENYLQESQQQQQQHQMQQMQQLHHNQDY--KLYERGNII----------AASKYAT 107
            ||.::....:|.:.:...:.::.|.:.....|.|...  |...|.:|:          |.|..:.
Frog   213 SYSQTANLYDNEVAQDGAEVRRGQKENQGDKHQNGKIPPKRPPRKHIVDTYTDIYHTSAYSDASK 277

  Fly   108 PRPVEQIQHTHNGSAQIYAPTAQILGQRIAPQKHS-PVYENLEFYGQFDSNHKRAQPQSPGSRQS 171
            .|.::..:..|..:....:.:.:||.|....:..| |..||::                 .:::|
Frog   278 KRLIDNTEDWHPRTGTTQSRSFRILAQMTGTEHMSEPEPENVQ-----------------KTKES 325

  Fly   172 AILNGYL--------------LMQPIRAGRFA-HTPVPENQGSASLGTTRAAGGPPPPS------ 215
            .|.||.:              |.|...|...| .|.||....:..|..:..    |.|:
Frog   326 NICNGDISTSAESPNGREDRKLSQNAEACSVATQTDVPVEDVTLILDLSER----PEPALLEREE 386

  Fly   216 ---GRSAALGPTGDLEEHAAPIYENIIPHSGQ-------RAQPQASPATATMYQEMQPTSNSSGS 270
               ..|....|    |:.|.....:..||..:       .:.|:|:|......|.::..|..:..
Frog   387 TYFVSSCRTSP----EKSAVQTSPSQSPHRRKSLFDNPLESLPKAAPFPPATVQILKVNSQVATI 447

  Fly   271 SSTAGLDLNALLASPMHQRSISSNTASSSSL--------------GSPTQRYRNLSLPSHLSPVP 321
            :.||.:.:.:.:..|   .|:..|::|::::              ...||....:.:|:. ||.
Frog   448 AKTASVYMRSSMVIP---DSLLENSSSAATVINGTGTKINAKEKCSIATQTCDKVLIPAS-SPC- 507

  Fly   322 TAQSVAKLQQHTPVKSPGGAINVSVNPNYIEDINSSDYVC---MTANLHRNTAAGLATGRAAATG 383
            ..:.:|.:...||...|...|  :.||   .|.......|   :.|.|...|.....:..||.|.
Frog   508 AVEYIASVIPSTPQVPPRQYI--AANP---LDTLPKCAPCPPPVLAPLTIQTCKSKVSAVAAVTA 567

  Fly   384 APAQRTVQEPPIITSSLAMGMATAAPPTTS---NAPT-------------SAAAAPAAPTSTASL 432
            ....:.....|.::.||...:..:..|.:|   :.||             |..:....|.:..|.
Frog   568 IVGAQARLSDPFVSRSLLDALLISPIPKSSFPTSKPTRKSTGGLYTGHNHSNVSVEVPPATATSS 632

  Fly   433 RATPIAMTAPLA---VATSPT-----PSQGSTAVNA--ALKPRRGLTKNLLPYSVTPPRPAGPTE 487
            :..|.:..:|.:   |.:.||     ||.|....||  |:||   :..|   .||.||
Frog   633 KIMPSSYKSPPSSKPVTSKPTGWQTVPSSGQVTNNASNAVKP---VANN---KSVPPP------- 684

  Fly   488 AQRKIEELTRQLEEEIEQSEEH---GEYFGICHTCGEKVKGAGQACQAMGNLYHTNCFICCSCGR 549
               .||:     ::.:.|..||   |....:|..|.:.::  |....|:|..:|...|.|..|..
Frog   685 ---WIED-----QDTLVQRAEHIPAGTRTPMCAICNKVIR--GPFLLALGKSWHPEEFNCAHCKS 739

  Fly   550 ALRGKAFYNVHGRVYCEEDYMYSGFQQTAEKCAICGHLIMEMILQAMGKSYHPGCFRCCVCNECL 614
            ::....|....|.:|||..|.    :..|.:||.|...|:..::.|:.:::|..||.|..|...:
Frog   740 SMAEMGFVEEKGGLYCEICYE----KLFAPECARCQRKILGEVINALKQTWHVSCFVCVACQTPI 800

  Fly   615 DGVPFTVDVDHKIYCVNDYHRMFAPKCASCGKGITPVEGTDETVRVVSMDKDFHVDCYICEECGM 679
            ....|.:: |.:.||..||:.:|...|..|.   .|:|..|..:.  ::...:|..|::|..|
Frog   801 RNSVFHLE-DGEPYCETDYYSLFGTICHGCE---FPIEAGDRFLE--ALGHTWHNTCFVCTIC-- 857

  Fly   680 QLTDEPDKRCYPLDG--------RLLCR 699
                     |..|:|        :|||:
Frog   858 ---------CENLEGQTFFSKKDKLLCK 876

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
jub	NP_572930.3	LIM1_Ajuba_like	516..569	CDD:188738	14/52 (27%)
		LIM2_Ajuba_like	581..633	CDD:188741	14/51 (27%)
		LIM3_Ajuba_like	641..702	CDD:188822	15/67 (22%)
pdlim5	XP_012817118.2	PDZ	10..83	CDD:214570
		PRK14951	<80..216	CDD:237865	2/2 (100%)
		DUF4749	212..320	CDD:406377	20/106 (19%)
		LIM1_ENH	708..759	CDD:188837	14/52 (27%)
		LIM2_Enigma_like	767..818	CDD:188748	14/51 (27%)
		LIM3_ENH	826..880	CDD:188843	15/67 (22%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
	2	1.910