DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment jub and esn

DIOPT Version :9

Sequence 1:	NP_572930.3	Gene:	jub / 32351	FlyBaseID:	FBgn0030530	Length:	728	Species:	Drosophila melanogaster
Sequence 2:	NP_001260760.1	Gene:	esn / 53557	FlyBaseID:	FBgn0263934	Length:	1134	Species:	Drosophila melanogaster

Alignment Length:	796	Identity:	166/796 - (20%)
Similarity:	250/796 - (31%)	Gaps:	264/796 - (33%)

- Green bases have known domain annotations that are detailed below.

  Fly    54 RSYQRSPGAIENYLQESQQQQQQHQMQQMQQLHHNQDYKL------------------YERGN-- 98
            ||.:|:..|....|...::.::|.|..:|.|:...|..:|                  ..|||
  Fly    87 RSRRRAVSAERERLASRERLEEQVQPPKMPQIGAGQQSRLSTVTKLTPRKQSSKSTCSKHRGNAP 151

  Fly    99 ----IIAASKYAT-PR-------PVEQIQHTHNGSAQIYAPTAQILGQRIAPQKHSPVYENLEFY 151
                |.:|.:..| |:       |.|......|.|.   |||   |...:| |....|...|...
  Fly   152 AKCIIKSAVRTKTKPKATTITLAPYEIALELPNESP---APT---LAMAVA-QSSGCVQRKLSSE 209

  Fly   152 GQFDSNHKRAQPQSPGSRQSAILNGYLLMQPIRAGRFAHTPVPENQGSASLGTTRAAGGPPPPSG 216
            .||.|:......::....:.|:|.|.|  .|.:..|.....:.......:|...|         .
  Fly   210 DQFHSSGISCNGETDDDVEVAMLTGSL--TPSQIARIQGQQILRYDDLRNLNRCR---------N 263

  Fly   217 RSAA-LGPTGDLEE-----------------------HAAPIYENIIPHSGQRAQPQASPATA-- 255
            |:|. |.|. |.|:                       ..:.|.|.:....|...:|....|||
  Fly   264 RNAVWLNPK-DTEQLLEVDKSRRKANCYFNQAIADDIQLSDIEEQLARFDGHSKRPPPPAATAPK 327

  Fly   256 -----TMYQEMQPT--SNSSGSSSTAGLDLNALLASPMHQR-----SISSNTASSSSLGSPTQRY 308
                 .:.::.:||  ..|||:...|          |..|:     |.|..|.:.|.|.......
  Fly   328 ITQPSQVIEKFKPTPAPRSSGNMQQA----------PQQQQHPHPPSSSYYTQTESELLQIEAGG 382

  Fly   309 RNLSLPSHLSPVPTAQSVAKLQQHTPVKSPGGAINVSVNPNYIEDINSSDYVCMTANLHRNTAAG 373
            ..|:..||                  .:.|..||:               .|..||:|...:||.
  Fly   383 TGLTFASH------------------SQRPESAIS---------------QVASTAHLDVPSAAS 414

  Fly   374 LATGRAAATG-------------APAQRTVQEPPIITSSLAMGMATAAPPTTSNAPTSAAAAPAA 425
            ..:|.:|.:|             :|.||...:||                  |:.|.::.   |:
  Fly   415 SGSGGSAVSGGSGGAPESAGRFVSPLQRRHCQPP------------------SHLPLNSV---AS 458

  Fly   426 PTSTASLRATPIAMTAPLAVA------------TSPTPSQGSTAVNAALKPRRGLTKNLLP---- 474
            |..|||.::.       .|||            .....||.......||:....:...|.|
  Fly   459 PLRTASYKSA-------AAVAGHGFHHSHHQQLDFQRNSQSDDDSGCALEEYTWVPPGLRPDQVR 516

  Fly   475 --YSVTP----PRPAGPTEAQRKIEELTRQL--------------EEE-----IEQSEEHGEYFG 514
              :|..|    |....|.|..| :::|..||              :||     |..::...|..|
  Fly   517 LYFSQLPDDKVPYVNSPGEKYR-VKQLLHQLPPQDNEVRYCHSLSDEERKELRIFSAQRKREALG 580

  Fly   515 -----------ICHTCGEKVKG----------AGQACQAMGNLYHTNCFICCSCGRALRGKAFYN 558
                       .|..|.|.:.|          ..|.|      :|..||:|..|...|....::.
  Fly   581 RGAVRLLSDERPCKGCEEPLSGGDIVVFAQRLGAQLC------WHPGCFVCSVCKELLVDLIYFQ 639

  Fly   559 VHGRVYCEEDYMYSGFQQTAEKCAICGHLIM-EMILQAMGKSYHPGCFRCCVCNECLDGVPFTVD 622
            ..|.:||...:.    :....:|:.|..:|. :...:|.|:::|...|.|..|...|.|..:.:.
  Fly   640 RDGNLYCGRHHA----ETQKPRCSACDEIIFSDECTEAEGRTWHMKHFACQECEHQLGGQRYIMR 700

  Fly   623 VDHKIYCVNDYHRMFAPKCASCGKGITPVEGTDETVRVVSMDKD---FHV--DCYICEECGMQLT 682
             :.|.||:..:..|||..|..||:    |.|.|:.    .|..|   :|.  .|:.|..|...|.
  Fly   701 -EGKPYCLACFDTMFAEYCDYCGE----VIGVDQG----QMSHDGQHWHATDQCFSCCTCRCSLL 756

  Fly   683 DEPDKRCYPLDGRLLC 698
            ..|   ..|..|.:.|
  Fly   757 GRP---FLPRRGTIYC 769

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
jub	NP_572930.3	LIM1_Ajuba_like	516..569	CDD:188738	15/62 (24%)
		LIM2_Ajuba_like	581..633	CDD:188741	14/52 (27%)
		LIM3_Ajuba_like	641..702	CDD:188822	17/63 (27%)
esn	NP_001260760.1	PET_Prickle	492..588	CDD:193602	18/96 (19%)
		LIM1_Prickle	593..651	CDD:188799	15/63 (24%)
		LIM2_Prickle	656..711	CDD:188802	14/55 (25%)
		LIM3_Prickle	716..774	CDD:188804	17/65 (26%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_KOG1704
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
	2	1.810