DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment jub and PRICKLE3

DIOPT Version :9

Sequence 1:	NP_572930.3	Gene:	jub / 32351	FlyBaseID:	FBgn0030530	Length:	728	Species:	Drosophila melanogaster
Sequence 2:	NP_006141.2	Gene:	PRICKLE3 / 4007	HGNCID:	6645	Length:	615	Species:	Homo sapiens

Alignment Length:	308	Identity:	73/308 - (23%)
Similarity:	114/308 - (37%)	Gaps:	80/308 - (25%)

- Green bases have known domain annotations that are detailed below.

  Fly   458 VNAALKPRR------GLTKNLLPYSVTPPRPAGPTEAQRKIEELTRQL--------------EEE 502
            |...|||.:      .|.::.:||..:|..       :.:|::|..||              |||
Human    96 VPPGLKPEQVYQFFSCLPEDKVPYVNSPGE-------KYRIKQLLHQLPPHDSEAQYCTALEEEE 153

  Fly   503 IEQ-----SEEHGEYFG--------------ICHTCGEKVKGAGQACQA----MGNLYHTNCFIC 544
            .::     .:...|..|              ||..||:::.|...|..|    :|..:|..||:|
Human   154 KKELRAFSQQRKRENLGRGIVRIFPVTITGAICEECGKQIGGGDIAVFASRAGLGACWHPQCFVC 218

  Fly   545 CSCGRALRGKAFYNVHGRVYCEEDYMYSGFQQTAE----KCAICGHLIME-MILQAMGKSYHPGC 604
            .:|...|....::...|:|||...:        ||    :|..|..:|.. ...:|.|:.:|...
Human   219 TTCQELLVDLIYFYHVGKVYCGRHH--------AECLRPRCQACDEIIFSPECTEAEGRHWHMDH 275

  Fly   605 FRCCVCNECLDGVPFTVDVDHKIYCVNDYHRMFAPKCASCGKGITPVEGTDETVRVVSMDKDFHV 669
            |.|..|...|.|..:.:. ..:.:|...|....|..|..||:.|    |.|:. ::....:.:|.
Human   276 FCCFECEASLGGQRYVMR-QSRPHCCACYEARHAEYCDGCGEHI----GLDQG-QMAYEGQHWHA 334

  Fly   670 D--CYICEECGMQLTDEPDKRCYPLDGRLLC-RGCHLQRLALQSSPHA 714
            .  |:.|..||..|...|   ..|..|.:.| |.|     :|.|.|.|
Human   335 SDRCFCCSRCGRALLGRP---FLPRRGLIFCSRAC-----SLGSEPTA 374

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
jub	NP_572930.3	LIM1_Ajuba_like	516..569	CDD:188738	17/56 (30%)
		LIM2_Ajuba_like	581..633	CDD:188741	12/52 (23%)
		LIM3_Ajuba_like	641..702	CDD:188822	17/63 (27%)
PRICKLE3	NP_006141.2	Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	1..26
		PET_Prickle	82..178	CDD:193602	17/88 (19%)
		LIM1_Prickle	186..244	CDD:188799	17/65 (26%)
		LIM2_Prickle	249..304	CDD:188802	12/55 (22%)
		LIM3_Prickle	309..367	CDD:188804	18/70 (26%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	396..567
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	587..615
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_KOG1704
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	2	1.810