DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment jub and Limd1

DIOPT Version :9

Sequence 1:	NP_572930.3	Gene:	jub / 32351	FlyBaseID:	FBgn0030530	Length:	728	Species:	Drosophila melanogaster
Sequence 2:	NP_038888.2	Gene:	Limd1 / 29806	MGIID:	1352502	Length:	668	Species:	Mus musculus

Alignment Length:	726	Identity:	246/726 - (33%)
Similarity:	323/726 - (44%)	Gaps:	198/726 - (27%)

- Green bases have known domain annotations that are detailed below.

  Fly    72 QQQQQHQMQQMQQLHH------NQDYKLYERGNIIAASKYATPRPVEQIQ---HTHNGSAQIYAP 127
            |||||.|:.|.:.|..      |...:....|.:.|......|..|..:.   .|...:||...|
Mouse    58 QQQQQQQLLQEEALPRAGRSPVNGGNRQGASGKLAADGAAKPPLAVPTVAPGLATTTAAAQPSYP 122

  Fly   128 TAQILGQRIAPQKHS--PVYENL-EFYGQFDSNHKRAQPQSPGSRQSAIL------NGYLLMQPI 183
            :.:   |||.|..|.  |..:|. ...|...|........||.....:.|      :.:.|..|.
Mouse   123 SQE---QRIRPSAHGARPGSQNCGSREGPVSSQRPALHGLSPSCEDPSCLTHGDYYDNFSLASPQ 184

  Fly   184 RAGRFAHTPVPENQGSASLGTTRAAGGPPPPSGRSAALGPTGDLEEHAAPIYENIIPHSGQRAQP 248
            ...:      ||...|.|||.  .:|.|..|...|......||  .|         |:     ||
Mouse   185 WGDK------PEGCPSVSLGV--GSGWPGCPGNDSTLPKSCGD--HH---------PY-----QP 225

  Fly   249 QASPATATMYQEMQPTSNSSGSSSTAGLDLNALLASPMHQRSISSNTASSSSLGSPTQRYRNLSL 313
            |.|..             .||.|..:|:                  :.....:|
Mouse   226 QLSTV-------------CSGRSFESGI------------------SGQDGGIG----------- 248

  Fly   314 PSHLSPVPTA-QSVAKLQQHTPVKSPGGAINVSVNPNYIEDINSSDYVCMTANLHRNTAAGLATG 377
             .|.|..||. .|.|..|:              ||..:                   ::.||..|
Mouse   249 -GHSSEKPTGLWSTASSQR--------------VNLGF-------------------SSMGLENG 279

  Fly   378 RAAATGAPAQRTVQEPPIITSSLAMGMATAAP----------------------PTTSNAPTSAA 420
                |.|..:.|....|::.||.:.|   |.|                      |...:.|.|..
Mouse   280 ----TSAQPKGTTVSAPMVPSSASQG---ACPKRDSGLGYEASGRVFKPLVDTQPWLQDGPKSYL 337

  Fly   421 AAPAAPTSTASLRATPIAMTAPL-------AVATSPTPSQGST--------------------AV 458
            :..|..:|||...:|...||..|       ...|||.||..|.                    :.
Mouse   338 SVSAPLSSTAGKDSTQPGMTTGLDPKFGCVESGTSPKPSPTSNVHPVMSTPSELSCKESSPSWST 402

  Fly   459 NAALKPRRGLTKNLLPYSVTPPR------------PAGPTEAQRKIEELTRQLEEEIEQSEEHGE 511
            :::|:|       :||.|.||.|            ..||:.|:.|:|.||::||.|:: :....:
Mouse   403 DSSLEP-------VLPGSPTPSRVRLPCQTLAPGPELGPSTAELKLEALTQRLEREMD-AHPKAD 459

  Fly   512 YFGICHTCGEKVKGAGQACQAMGNLYHTNCFICCSCGRALRGKAFYNVHGRVYCEEDYMYSGFQQ 576
            |||.|..|.:.|.||||||||||:|||..||.|.:|.|.|||||||.|:|:|:||||::||||||
Mouse   460 YFGSCVKCSKGVFGAGQACQAMGDLYHDACFTCAACSRKLRGKAFYFVNGKVFCEEDFLYSGFQQ 524

  Fly   577 TAEKCAICGHLIMEMILQAMGKSYHPGCFRCCVCNECLDGVPFTVDVDHKIYCVNDYHRMFAPKC 641
            :|::|.:||||||:|||||:|||||||||||.:|||||||||||||.::|||||.|||::.||||
Mouse   525 SADRCFLCGHLIMDMILQALGKSYHPGCFRCVICNECLDGVPFTVDSENKIYCVRDYHKVLAPKC 589

  Fly   642 ASCGKGITPVEGTDETVRVVSMDKDFHVDCYICEECGMQLTDEPDKRCYPLDGRLLCRGCHLQRL 706
            |:||..|.|.||:|||:||||||:|:||:||.||:||::|.||...|||||:..|.|..||::||
Mouse   590 AACGLPILPPEGSDETIRVVSMDRDYHVECYHCEDCGLELNDEDGHRCYPLEDHLFCHSCHVKRL 654

  Fly   707 ALQSSPHARHQ 717
            ....||...||
Mouse   655 EKGPSPAPLHQ 665

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
jub	NP_572930.3	LIM1_Ajuba_like	516..569	CDD:188738	34/52 (65%)
		LIM2_Ajuba_like	581..633	CDD:188741	41/51 (80%)
		LIM3_Ajuba_like	641..702	CDD:188822	36/60 (60%)
Limd1	NP_038888.2	Mediates nuclear export. /evidence=ECO:0000250	54..128		18/72 (25%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	74..160		18/88 (20%)
		Interaction with EGLN1/PHD2. /evidence=ECO:0000250	181..256		26/141 (18%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	239..258		6/48 (13%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	277..309		10/38 (26%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	340..414		18/80 (23%)
		Interaction with RB1. /evidence=ECO:0000250	396..434		8/44 (18%)
		Necessary for nuclear localization. /evidence=ECO:0000250	464..668		133/202 (66%)
		LIM1_Ajuba_like	464..517	CDD:188738	34/52 (65%)
		LIM2_Ajuba_like	529..581	CDD:188741	41/51 (80%)
		LIM3_Ajuba_like	589..650	CDD:188822	36/60 (60%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	1	1.000	102	1.000	Domainoid score	I6808
eggNOG	1	0.900	-	-		E1_KOG1704
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	1	1.000	-	-		FOG0004196
OrthoInspector	1	1.000	-	-		otm43371
orthoMCL	1	0.900	-	-		OOG6_106886
Panther	1	1.100	-	-	LDO	PTHR24219
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	1	1.000	-	-		X3625
SwiftOrtho	1	1.000	-	-
TreeFam	1	0.960	-	-
	10	9.770