DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment jub and Zyx

DIOPT Version :9

Sequence 1:	NP_572930.3	Gene:	jub / 32351	FlyBaseID:	FBgn0030530	Length:	728	Species:	Drosophila melanogaster
Sequence 2:	NP_001276546.1	Gene:	Zyx / 22793	MGIID:	103072	Length:	564	Species:	Mus musculus

Alignment Length:	647	Identity:	179/647 - (27%)
Similarity:	252/647 - (38%)	Gaps:	134/647 - (20%)

- Green bases have known domain annotations that are detailed below.

  Fly   106 ATPRPVEQIQHTHNGSAQIYAPTAQILGQRIAPQ-KHSPVYENLEFYGQFDSNHKRAQPQSPGSR 169
            |.|||...|      |..:.||..      .||| |.:||.          :...:..|..||..
Mouse     2 AAPRPPPAI------SVSVSAPAF------YAPQKKFAPVV----------APKPKVNPFRPGDS 44

  Fly   170 QSAILNGYLLMQPIRAGRFAHTPVPE------------NQGSASLGTTRAAGGPPPPSGRSAALG 222
            :..:..|   .|..:.||....|.|.            .:|..|.|....|..||||........
Mouse    45 EPPVAAG---AQRAQMGRVGEIPPPPPEDFPLPPPPLIGEGDDSEGALGGAFPPPPPPMIEEPFP 106

  Fly   223 PTGDLEEHAAPIYENIIPHSGQRAQPQASPATATMYQEMQPTSNSSGSSSTAGLDLNALLASPMH 287
            |        ||:.|:|.|......:.:..|...|   ::.|.......|....:|..:.|...|.
Mouse   107 P--------APLEEDIFPSPPPPLEEEGGPEAPT---QLPPQPREKVCSIDLEIDSLSSLLDDMT 160

  Fly   288 QRSISSNTASSSSLGSP-----------------TQRYRNLSLPSHLSPVPTAQSVAKLQQHT-P 334
            :........||..:..|                 |........||...|.|..|:..::|.|. |
Mouse   161 KNDPFKARVSSGYVPPPVATPFVPKPSTKPAPGGTAPLPPWKTPSSSQPPPQPQAKPQVQLHVQP 225

  Fly   335 VKSPGGAINVSVNPNYIEDINSSDYVCMTANLHRNTAAGLATGRAAATGAPAQRTVQEPPIITSS 399
            ...|      .|.|..:...|:.                 ..|..:....||.:.....|..|..
Mouse   226 QAKP------HVQPQPVSSANTQ-----------------PRGPLSQAPTPAPKFAPVAPKFTPV 267

  Fly   400 LAMGMATAAPPTTSNAPTSAAAAPAAPTSTASLRATPIAMT------APLAVA---TSPTPSQGS 455
            ::. .:..||......|......|.||:|.::....|.:.|      .||...   ..|.|:|..
Mouse   268 VSK-FSPGAPSGPGPQPNQKMVPPDAPSSVSTGSPQPPSFTYAQQKEKPLVQEKQHPQPPPAQNQ 331

  Fly   456 TAVNAALKPRRGLTKNLLPYSVTPPRPAGPTE-AQRKIEELTRQLEEEIEQSEEHGEYFGI---- 515
            ..|.:                     |.||.. ..:::||| .||.:::.|..||.:...:
Mouse   332 NQVRS---------------------PGGPGPLTLKEVEEL-EQLTQQLMQDMEHPQRQSVAVNE 374

  Fly   516 -CHTCGEKVKGAGQACQAMGNLYHTNCFICCSCGRALRGKAFYNVHGRVYCEEDYMYSGFQQTAE 579
             |..|.:.:..|..|.:|:|.|:|..||.|..|.:.|:|:.||::.|..|||..|     ..|.|
Mouse   375 SCGKCNQPLARAQPAVRALGQLFHITCFTCHQCQQQLQGQQFYSLEGAPYCEGCY-----TDTLE 434

  Fly   580 KCAICGHLIMEMILQAMGKSYHPGCFRCCVCNECLDGVPFTVDVDHKIYCVNDYHRMFAPKCASC 644
            ||..||..|.:.:|:|.||:|||.||.|.||...|:|..|.||..::.:||.|||:.:||:|:.|
Mouse   435 KCNTCGQPITDRMLRATGKAYHPQCFTCVVCACPLEGTSFIVDQANQPHCVPDYHKQYAPRCSVC 499

  Fly   645 GKGITPVEGTDETVRVVSMDKDFHVDCYICEECGMQLTDEPDKR-CYPLDGRLLCRGCHLQR 705
            .:.|.|..|.|||||||::||:||:.||.||:||..|:.|.|.. |:||||.:|||.||..|
Mouse   500 SEPIMPEPGRDETVRVVALDKNFHMKCYKCEDCGKPLSIEADDNGCFPLDGHVLCRKCHSAR 561

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
jub	NP_572930.3	LIM1_Ajuba_like	516..569	CDD:188738	20/52 (38%)
		LIM2_Ajuba_like	581..633	CDD:188741	23/51 (45%)
		LIM3_Ajuba_like	641..702	CDD:188822	33/61 (54%)
Zyx	NP_001276546.1	Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	30..141		26/134 (19%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	162..344		39/226 (17%)
		PHA03247	<175..368	CDD:223021	45/238 (19%)
		LIM	343..429	CDD:351770	28/86 (33%)
		LIM2_Zyxin	436..495	CDD:188739	27/58 (47%)
		LIM3_Zyxin	496..562	CDD:188819	36/66 (55%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_KOG1704
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	1	1.010	-	-		QHG54624
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	3	2.820