DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment jub and Lpp

DIOPT Version :9

Sequence 1:	NP_572930.3	Gene:	jub / 32351	FlyBaseID:	FBgn0030530	Length:	728	Species:	Drosophila melanogaster
Sequence 2:	NP_001139424.1	Gene:	Lpp / 210126	MGIID:	2441849	Length:	613	Species:	Mus musculus

Alignment Length:	672	Identity:	188/672 - (27%)
Similarity:	288/672 - (42%)	Gaps:	169/672 - (25%)

- Green bases have known domain annotations that are detailed below.

  Fly   113 QIQHTHN-GSAQIYAPTAQILGQRIAPQKHSPVYENLEFYGQFDSNHKRAQPQSPGSRQSAILNG 176
            :::.||: |:..|...|.|      .|:|::||......|..:         :.||.      .|
Mouse    22 RMETTHSFGNPSISVSTQQ------PPKKYAPVVAPKPKYNPY---------KQPGG------EG 65

  Fly   177 YLLMQPIRAGRFAHTPVP-ENQGSASLGTTRAAGGPPPPSGRSAALGPTGDLEEHAAPIYENIIP 240
            .||..|         |.| |:.|:...|....   ||||           .|:|.|..:
Mouse    66 DLLPPP---------PPPLEDPGTIPPGPGHF---PPPP-----------PLDEGAFKV------ 101

  Fly   241 HSGQRAQPQASPATATMYQEMQPTSNSSGSSSTAGLD-LNALLA-----SPMHQR--SISSNTAS 297
                   .|.:|...|:.:..        ||..|.:| |.::||     ||...|  ..|:::.:
Mouse   102 -------QQGNPGGKTLEERR--------SSLDAEIDSLTSILADLECSSPYKPRPPQGSASSIA 151

  Fly   298 SSSLGSPTQRYRNLSLPSHLSPVPTAQSVAKLQ---QHTPVK-SPGGAINVSVNPNYIEDINSSD 358
            |..:.:|...::.:.:|.......|.:|..|.|   |..|:. :|.|.:.....|.......:|.
Mouse   152 SPPVSTPVTGHKRMVIPQQPPLTATKKSATKPQPAPQAAPIPVTPIGTLKPQPQPVPASYTTAST 216

  Fly   359 YVCMTANLHRNTA-------AGLATGRAAATG------APAQRTVQEPPIITSSLAMGMATAAPP 410
            ....|.|:...:|       ||.::|:....|      .|...:.|.||..|   .:|...|..|
Mouse   217 SSRPTFNVQVKSAQPSPHYMAGPSSGQIYGPGPRGYNNQPVPVSGQCPPPPT---CVGTDYAYIP 278

  Fly   411 TTSNAPTS--------------------------------------------AAAAPAAPTSTAS 431
            .:.:.|.|                                            ||.||.|..:...
Mouse   279 PSGHPPESGYGYTSNQGRYYEPYYAAGPSYGGRSEGDTAYGQQVQPNTWKREAAYAPPASGNQNH 343

  Fly   432 LRATPIA------MTAPLAVATSPTPSQGSTAVNAALKPRRGLTKNLLPYSVTPP-RPAGPTEAQ 489
            ....|::      :|.|::...:|           .|:|:.|....:.|.|:.|. ||      :
Mouse   344 PGMYPVSGPKKTYITDPVSAPCAP-----------PLQPKGGYPGPMGPPSIPPSFRP------E 391

  Fly   490 RKIEELTRQLEEEIEQSEEHGEYFGICHTCGEKVKGAGQACQAMGNLYHTNCFICCSCGRALRGK 554
            .::|.||:::..::| :....:|||.|..|||.|.|.|..|.||..::|.:||.|..|...|||:
Mouse   392 DELEHLTKKMLYDME-NPPADDYFGRCARCGENVVGEGTGCTAMDQVFHVDCFTCIVCDVKLRGQ 455

  Fly   555 AFYNVHGRVYCEEDYMYSGFQQTAEKCAICGHLIMEMILQAMGKSYHPGCFRCCVCNECLDGVPF 619
            .||.|..:.|||..|:     .|.|:|::|...|||.||:|.||:|||.||.|.:|:..|||:||
Mouse   456 PFYAVEKKAYCEPCYI-----NTLEQCSVCSKPIMERILRATGKAYHPHCFTCVMCHRSLDGIPF 515

  Fly   620 TVDVDHKIYCVNDYHRMFAPKCASCGKGITPVEGTDETVRVVSMDKDFHVDCYICEECGMQLTDE 684
            |||....|:|:.|:|:.|||:|:.|.:.|.|..|.:||||:|::|:||||.||.||:||..|::.
Mouse   516 TVDACGLIHCIEDFHKKFAPRCSVCKEPIMPAPGQEETVRIVALDRDFHVHCYRCEDCGGLLSEG 580

  Fly   685 PDKRCYPLDGRLLCRGCHLQRL 706
            .::.||||||.:||:.|:..|:
Mouse   581 DNQGCYPLDGHILCKTCNSARI 602

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
jub	NP_572930.3	LIM1_Ajuba_like	516..569	CDD:188738	24/52 (46%)
		LIM2_Ajuba_like	581..633	CDD:188741	27/51 (53%)
		LIM3_Ajuba_like	641..702	CDD:188822	30/60 (50%)
Lpp	NP_001139424.1	Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	1..119		34/161 (21%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	133..259		25/125 (20%)
		PRK14971	<139..>240	CDD:237874	20/100 (20%)
		dnaA	192..>388	CDD:237605	36/209 (17%)
		LIM1_TRIP6	417..470	CDD:188736	24/52 (46%)
		LIM	477..536	CDD:351770	31/58 (53%)
		LIM	537..602	CDD:351770	31/64 (48%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_KOG1704
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	1	1.010	-	-		QHG54624
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	3	2.820