DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment jub and Ajuba

DIOPT Version :9

Sequence 1:	NP_572930.3	Gene:	jub / 32351	FlyBaseID:	FBgn0030530	Length:	728	Species:	Drosophila melanogaster
Sequence 2:	NP_034720.2	Gene:	Ajuba / 16475	MGIID:	1341886	Length:	547	Species:	Mus musculus

Alignment Length:	588	Identity:	213/588 - (36%)
Similarity:	284/588 - (48%)	Gaps:	134/588 - (22%)

- Green bases have known domain annotations that are detailed below.

  Fly   152 GQFDSNHKRA------QPQSPGSRQSAILNGYLLMQPIRAGRFAHTPVPENQGSASLGTTRAAGG 210
            |...|.|:.|      :|..|...|.          |:.|.|.|.......:...|.     .||
Mouse    53 GPRKSGHRGANGGPGDEPLEPAREQG----------PLDAERNARGSFEAQRFEGSF-----PGG 102

  Fly   211 PPPPSGRSAALGPTGDLE-EHAAPIYENIIPHSGQRAQPQASPATATMYQEMQPTS-------NS 267
            |||.......|....|.. |..||           ...|::|.|:::.....:|:|       :.
Mouse   103 PPPTRALPLPLSSPPDFRLETTAP-----------ALSPRSSFASSSASDASKPSSPRGSLLLDG 156

  Fly   268 SGSSSTAGLDLNALLASPMHQRSISSNTASSSSLGSPTQRYRNLSLPSHLSPVPTAQSVAKLQQH 332
            :|:|...|       :.|      .||..|..|:|. .||        |.||:|....:..|...
Mouse   157 AGASGAGG-------SRP------CSNRTSGISMGY-DQR--------HGSPLPAGPCLFGLPLT 199

  Fly   333 T-PVKSPGGAINVSVNPNYIEDINSS-DYVCMTANLHRNT----------------AAGLATGRA 379
            | |...||||      |:...::::: |.:|    .||:.                :.|..||..
Mouse   200 TAPAGYPGGA------PSAYPELHAALDRLC----AHRSVGFGCQESRHSYPPALGSPGALTGAV 254

  Fly   380 AATGAPAQRTVQEPPIITSSLAMGMATAAPPTTSNAPTSAAAAPAAPTSTASLRATPIAMTAPLA 444
            ..|..|.:|...:|              ...:.:.....||.|......||.||         |.
Mouse   255 VGTAGPLERRGAQP--------------GRHSVTGYGDCAAGARYQDELTALLR---------LT 296

  Fly   445 VATSPTPSQGSTAVNAALKPRRGLTKNLLPYSVTPPRPAGPTEAQRKIEELTRQLEEEIEQSEEH 509
            |||....: |:....:.::| .||.::        |.|..| ||.|          ..|.:.|..
Mouse   297 VATGGREA-GARGEPSGIEP-SGLEES--------PGPFVP-EASR----------SRIREPEAR 340

  Fly   510 GEYFGICHTCGEKVKGAGQACQAMGNLYHTNCFICCSCGRALRGKAFYNVHGRVYCEEDYMYSGF 574
            .:|||.|..|.:.:.|...||||:.:||||.||:||||||.||.||||:|:|.|||||||::|||
Mouse   341 EDYFGTCIKCNKGIYGQSNACQALDSLYHTQCFVCCSCGRTLRCKAFYSVNGSVYCEEDYLFSGF 405

  Fly   575 QQTAEKCAICGHLIMEMILQAMGKSYHPGCFRCCVCNECLDGVPFTVDVDHKIYCVNDYHRMFAP 639
            |:.||||.:|||||:|.||||||||||||||||.|||:||||||||||..:::|||.|||:.:||
Mouse   406 QEAAEKCCVCGHLILEKILQAMGKSYHPGCFRCIVCNKCLDGVPFTVDFSNQVYCVTDYHKNYAP 470

  Fly   640 KCASCGKGITPVEGTDETVRVVSMDKDFHVDCYICEECGMQLTDEPDKRCYPLDGRLLCRGCHLQ 704
            |||:||:.|.|.||.::.|||:|||:|:|.:||.||:|.|||:||....|:||||.|||.|||:|
Mouse   471 KCAACGQPILPSEGCEDIVRVISMDRDYHFECYHCEDCRMQLSDEEGCCCFPLDGHLLCHGCHMQ 535

  Fly   705 RLA 707
            ||:
Mouse   536 RLS 538

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
jub	NP_572930.3	LIM1_Ajuba_like	516..569	CDD:188738	32/52 (62%)
		LIM2_Ajuba_like	581..633	CDD:188741	39/51 (76%)
		LIM3_Ajuba_like	641..702	CDD:188822	35/60 (58%)
Ajuba	NP_034720.2	PreLIM	1..344		84/392 (21%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	1..182		36/168 (21%)
		Nuclear localization signal. /evidence=ECO:0000255	289..297		5/16 (31%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	302..332		10/50 (20%)
		LIM1_Ajuba_like	347..400	CDD:188738	32/52 (62%)
		LIM2_Ajuba_like	412..464	CDD:188741	39/51 (76%)
		LIM3_Ajuba_like	472..533	CDD:188822	35/60 (58%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	1	1.000	102	1.000	Domainoid score	I6808
eggNOG	1	0.900	-	-		E1_KOG1704
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	1	1.050	321	1.000	Inparanoid score	I2504
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	O	PTHR24219
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	1	0.960	-	-
	6	5.920