DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Nup93-1 and Nup93-2

DIOPT Version :9

Sequence 1:	NP_572929.1	Gene:	Nup93-1 / 32350	FlyBaseID:	FBgn0027537	Length:	823	Species:	Drosophila melanogaster
Sequence 2:	NP_650404.1	Gene:	Nup93-2 / 41804	FlyBaseID:	FBgn0038274	Length:	796	Species:	Drosophila melanogaster

Alignment Length:	829	Identity:	372/829 - (44%)
Similarity:	540/829 - (65%)	Gaps:	39/829 - (4%)

- Green bases have known domain annotations that are detailed below.

  Fly     1 MDLMELLKQAQRLTNETNTDTEVPGVERTMSQVLQATKEFHSRVTQMGTNDLQAHILLGSKGVDL 65
            |||..||::||.|.|:...:.|:|.||||:.|||:||.|.||||||.|..::|||||||||||||
  Fly     1 MDLNTLLQRAQNLNNDAKAECELPAVERTLQQVLRATTELHSRVTQTGCKEIQAHILLGSKGVDL 65

  Fly    66 PKLTQKLESLSARQTFEPIDPVTETNVQAYLKNERENAILSVIDETNRSIFKSVERQKWRCIYSE 130
            |||.||||:||||:||||:|...:|:|:.:|||||||||||||::|.::|..|..:|:|..:...
  Fly    66 PKLNQKLEALSARKTFEPLDVKADTDVRTFLKNERENAILSVIEDTKKNISDSANKQRWASMNKV 130

  Fly   131 WGEEKEALLNALVGPNQQDFPDVQFQIVPTAMADEPTPYSQLNGHEQMYAEQIAIHNQSII-LGR 194
            |.|||..||:||:.|: |:|.|:|....||.:.....|.|.|:..|.:||:::..:|:.:: ...
  Fly   131 WNEEKTRLLDALIAPS-QNFIDLQRLPEPTIVNPLCQPRSCLDPLELVYAQELRHYNELLLKSSH 194

  Fly   195 RPNLLSTLAHVVQDSFNDESVAEMWNVLQFMTAL-PPVSSTIDPIKNRQTSPQFVEQARTYLERR 258
            ||||:...||:.| ||.|..:.:||.:|..:|.: .|:.|  ||||:||..|:||..|::|||||
  Fly   195 RPNLVQKFAHLSQ-SFGDCRLTDMWTLLACVTQISEPLRS--DPIKSRQQRPEFVTYAKSYLERR 256

  Fly   259 YRTYMRKFIVANLAKARRGGIPSVYHMVRSYVGVTLQGQRALYGLHDVNNGQPLWPHVYYSLRSG 323
            ||.:|...:..:.|.       :.|.:|.:||....:.|:.: ||.|.....||||.|||.||.|
  Fly   257 YRVFMCSQVGGSYAN-------NSYQLVVAYVNHRFRAQQTI-GLVDTVREIPLWPLVYYGLRCG 313

  Fly   324 DMDAAALYLKESGTCPDLLTLLTLRKNGDRDNLMVKLEGQLKLEYNSRLRACTDPYKKAVYVVLL 388
            .:..|..:|:|:|:..|....|...:|....|  .|:|.||:|:|.:::|..||.||||||.:||
  Fly   314 AVKVAVEFLREAGSSHDEFAQLVADRNAGETN--SKIENQLRLQYANKIRNSTDAYKKAVYCILL 376

  Fly   389 ACDPHFTHVELMRSIDDFLWMQLSILRRSDQSDSNTEQLTFSGLQSLILEKYGENYFNAREKAAL 453
            .||.:..|.|:.::|||||||:|::::..|..:       :..|||:|||:|||.|||||::..|
  Fly   377 GCDVNEVHGEVAKTIDDFLWMRLAMIQPGDADN-------YGKLQSMILEQYGEKYFNARQQPYL 434

  Fly   454 YFQVLTLTGQFEAAIEFLARTEKNRTHAIHMAIALNEISMLGTPRSVEQSLLSSDPDDPKPMKRL 518
            ||:.|.||||||||||||||.::||.||:||||||.|:.:||:.|||.|.|||.|..||:|::||
  Fly   435 YFETLALTGQFEAAIEFLARQDENRAHAVHMAIALFELGLLGSARSVSQPLLSIDIKDPQPLRRL 499

  Fly   519 NLVRLIVMYTKCFERTDTTQALHYYYLLRNFKSENGRGNVMLTCVCDLLVEK--CDDEMLELIFG 581
            ||.|||..|.:.||||||::||||||.||..|...|| |:.:.|||||:|:.  .|..:.:||||
  Fly   500 NLTRLIRQYVQRFERTDTSEALHYYYTLRCLKDSKGR-NMFMACVCDLVVDSGVFDTTIFDLIFG 563

  Fly   582 TEDK--KNGLRYGGIYAEFQIHECDKYSLAEMVGDELSKRGDYELAIELYFIGGQLDKALRLVNS 644
            ....  :|.:. .|::.:|:..|.|..::|..|||||:..|::|::..||.:.|:.:.|::.:..
  Fly   564 KRQSSDQNDVN-SGLFRQFECPEFDTRTMAAQVGDELAALGNFEMSARLYEMAGKYNLAVKHICI 627

  Fly   645 LLAQVVHQPTQNGSVRNRLGDIINRLDAALVVRKSDVEVQVVVTYTVLTKVMKFFDHYHEGALRS 709
            |:|||||.||..||:|.|||....|.:..|.....|||.::..::.:|..::.||:.||:|...:
  Fly   628 LMAQVVHLPTLGGSLRERLGQDAQRFNQLLASDSIDVEPKMKSSFVLLQDLLIFFNFYHDGKFNA 692

  Fly   710 ALEILTNNHLIPASSLEVDECVTNIKRMGPEVIKVLPDILLASMDIVYQEYVKLMDSNETASGFF 774
            ||::|....|:|.:..:||..:.|:|::..||||||||:::|:|:|..::|.:|    :..||..
  Fly   693 ALDLLRQTQLVPNTLDDVDVVLGNVKQLSGEVIKVLPDVIVAAMEIAQKQYKQL----KAGSGSS 753

  Fly   775 DESKCVNKEPAVKHLRDRAKAFTNMAASVPYRMPSTTNQRLVQLEILMH 823
            .|      :..::.||.||||.:||||::|||:|:.||:||::||:.||
  Fly   754 LE------QTQMQQLRQRAKALSNMAATMPYRLPNDTNKRLIELELDMH 796

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Nup93-1	NP_572929.1	Nic96	215..808	CDD:309288	254/597 (43%)
Nup93-2	NP_650404.1	DUF2461	178..>238	CDD:295279	22/62 (35%)
Nup93-2	NP_650404.1	Nic96	213..781	CDD:282017	254/598 (42%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C45460697
Domainoid	1	1.000	62	1.000	Domainoid score	I3753
eggNOG	1	0.900	-	-		E1_KOG2168
Homologene	0	0.000	Not matched by this tool.
Inparanoid	1	1.050	91	1.000	Inparanoid score	I2268
Isobase	0	0.000	Not matched by this tool.
OMA	1	1.010	-	-		QHG59183
OrthoDB	1	1.010	-	-		D187731at2759
OrthoFinder	1	1.000	-	-		FOG0002723
OrthoInspector	1	1.000	-	-		otm26138
orthoMCL	1	0.900	-	-		OOG6_103333
Panther	1	1.100	-	-	P	PTHR11225
Phylome	1	0.910	-	-
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R780
SonicParanoid	1	1.000	-	-		X3522
	13	12.840