DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Nup93-1 and nup93

DIOPT Version :9

Sequence 1:	NP_572929.1	Gene:	Nup93-1 / 32350	FlyBaseID:	FBgn0027537	Length:	823	Species:	Drosophila melanogaster
Sequence 2:	NP_571056.2	Gene:	nup93 / 30172	ZFINID:	ZDB-GENE-990415-46	Length:	820	Species:	Danio rerio

Alignment Length:	846	Identity:	295/846 - (34%)
Similarity:	460/846 - (54%)	Gaps:	60/846 - (7%)

- Green bases have known domain annotations that are detailed below.

  Fly     5 ELLKQAQRLTNETNTDTEVPGVERTMSQVLQATKEFHSRV---TQMGTNDLQAHILLGSKGVDLP 66
            |||:||::|..||...:|:|.|||.:.::.||.:...||.   |...|.|::|.|||||:|:|:.
Zfish     8 ELLQQAEQLAAETEAVSELPHVERNLQEIQQAGERLRSRTLTRTSQDTADVKASILLGSRGLDIF 72

  Fly    67 KLTQKLESLSARQTFEPIDPVTETNVQAYLKNERENAILSVIDETNRSIFKSVERQKWRCIYSEW 131
            .::|:||||||..||||::||.:|::|.:|||||:||:||.|:|:.|..|...|......:..:|
Zfish    73 HISQRLESLSAATTFEPLEPVKDTDIQGFLKNERDNALLSAIEESRRRTFLLAEEYHRDSMLVQW 137

  Fly   132 GEEKEALLNALVGPNQQDFPDVQFQIVPTAMADEPTP-YSQLNGHEQMYAEQIAIHNQSIILGR- 194
            .:.|:.:|:.|:|.. :|..|...::.|:.:::...| .|.|:..|..|:.||.:.|:.|:.|.
Zfish   138 EQVKQRVLHTLLGAG-EDALDFSQEVEPSFVSEVGVPGRSALDSVEVAYSRQIYVFNEKIVNGHL 201

  Fly   195 RPNLLSTLAHVVQDSFNDESVAEMWNVLQFMT--ALPPVSSTIDPIKNRQTSPQFVEQARTYLER 257
            :|| |..|...|.:|.:|::|:|||.:::.||  .|.|...|:....:......||.||..:||.
Zfish   202 QPN-LGDLCASVAESLDDKNVSEMWLMVKQMTDVLLVPAKDTLKSRVSVDMQMAFVRQALQFLEN 265

  Fly   258 RYRTYMRKFIVANLAKARRGGIPSVYHMVRSYVGVTLQGQRALYGLHDVN-NGQPLWPHVYYSLR 321
            .|:.|....:..||.:|:.||:|..|.:|.|::.:.|  ...|.|..|.. .|.|:|..:|:.||
Zfish   266 SYKNYTLVTVFGNLHQAQLGGVPGTYQLVCSFLNIKL--PTPLPGRQDGEVEGHPVWALIYFCLR 328

  Fly   322 SGDMDAA--------------ALYLKESGTCPDLLTLLTLRKNGDRDNLMVKLEGQLKLEYNSRL 372
            .||:.||              .::.:|....||             ..|....|.:|:|.|...|
Zfish   329 CGDLSAAMQVVNKAQHQLGDFKIWFQEYMNSPD-------------RRLSPATENKLRLHYRRVL 380

  Fly   373 RACTDPYKKAVYVVLLACDPHFTHVELMRSIDDFLWMQLS-ILRRSDQSDSNTEQLTFSGLQSLI 436
            |...||||:|||.::..||....|.|:....:|:||::|: :....|.|.|..:::|.:.||..:
Zfish   381 RNSADPYKRAVYCLIGKCDIGDNHGEVADKTEDYLWLKLNQVCFDEDGSSSPQDRMTLAQLQKQL 445

  Fly   437 LEKYGENYFNAREKAALYFQVLTLTGQFEAAIEFLARTEKNRTHAIHMAIALNEISMLGTPRSVE 501
            ||.|||::|:|..:..||||||.||.||||||.||.|.|:.|:||:|:|:.|.|:.:|.......
Zfish   446 LEDYGESHFSASHQPFLYFQVLFLTAQFEAAIAFLFRVERLRSHAVHVALVLYELKLLLKSSGQS 510

  Fly   502 QSLLSSDPDDPKPMKRLNLVRLIVMYTKCFERTDTTQALHYYYLLRNFKSENGRGNVMLTCVCDL 566
            ..|||.:..||..::|||.:||:::||:.||.||..:||.|:|.|||.|...|. |:.:.||.:|
Zfish   511 AQLLSQEAGDPPMVRRLNFIRLLMLYTRKFESTDPREALQYFYFLRNEKDSQGE-NMFMRCVSEL 574

  Fly   567 LVEKCDDEMLELIFGTEDKKNGLRYGGIYAEFQIHECDKYSLAEMVGDELSKRGDYELAIELYFI 631
            ::|..:.:||   .|..: |:|.|..|:..:|   ..|..::...|..|...:|.:|.|::||.:
Zfish   575 VIESREFDML---LGRLE-KDGSRKPGVIDKF---AGDTRAIITKVASEAENKGLFEEAVKLYEL 632

  Fly   632 GGQLDKALRLVNSLLAQVVHQPTQNGSVRNRLGD----IINRLDAALVVRKSDVEVQVVVTYTVL 692
            ....||.|.|:|.||:.|:.|.::..|.:.||.:    |..|..|..|..:..|:    .|:.:|
Zfish   633 AKNADKVLELMNKLLSPVIAQVSEPQSNKERLKNMAVAIAERYRANGVAGEKSVD----NTFYLL 693

  Fly   693 TKVMKFFDHYHEGALRSALEILTNNHLIPASSLEVDECVTNIKRMGPEVIKVLPDILLASMDIVY 757
            ..:|.|||.||.|.:..|.:::....|:|.|...|:|.|...:....||...|.::|||:|:|::
Zfish   694 LDLMTFFDEYHAGHIDRAYDVIERLKLVPLSQDSVEERVAAFRNFSDEVRHNLSEVLLATMNILF 758

  Fly   758 QEYVKLMDSNETASGFFDESKCVNKEPAVKHLRDRAKAFTNMAASVPYRMPSTTNQRLVQLEILM 822
            .:|.:|..:.....|....:    .|.....||.:|:|....|..:||||...||.||||:|:||
Zfish   759 TQYKRLKGAAAGTPGRPQRT----LEDRDMLLRIQARALITFAGMIPYRMAGDTNARLVQMEVLM 819

  Fly   823 H 823
            :
Zfish   820 N 820

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Nup93-1	NP_572929.1	Nic96	215..808	CDD:309288	203/614 (33%)
nup93	NP_571056.2	GluZincin	4..>127	CDD:301352	56/118 (47%)
nup93	NP_571056.2	Nic96	220..804	CDD:282017	202/614 (33%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C170590017
Domainoid	1	1.000	318	1.000	Domainoid score	I1230
eggNOG	1	0.900	-	-		E1_KOG2168
Hieranoid	1	1.000	-	-
Homologene	0	0.000	Not matched by this tool.
Inparanoid	1	1.050	468	1.000	Inparanoid score	I1496
OMA	1	1.010	-	-		QHG59183
OrthoDB	1	1.010	-	-		D187731at2759
OrthoFinder	1	1.000	-	-		FOG0002723
OrthoInspector	1	1.000	-	-		otm26138
orthoMCL	1	0.900	-	-		OOG6_103333
Panther	1	1.100	-	-	O	PTHR11225
Phylome	1	0.910	-	-
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R780
SonicParanoid	1	1.000	-	-		X3522
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	1	0.960	-	-
ZFIN	0	0.000	Not matched by this tool.
	15	14.800