DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Nup93-1 and npp-13

DIOPT Version :9

Sequence 1:	NP_572929.1	Gene:	Nup93-1 / 32350	FlyBaseID:	FBgn0027537	Length:	823	Species:	Drosophila melanogaster
Sequence 2:	NP_740802.1	Gene:	npp-13 / 171774	WormBaseID:	WBGene00003799	Length:	787	Species:	Caenorhabditis elegans

Alignment Length:	835	Identity:	193/835 - (23%)
Similarity:	355/835 - (42%)	Gaps:	102/835 - (12%)

- Green bases have known domain annotations that are detailed below.

  Fly     9 QAQRLTNETNTDTEV-PGVERTMSQVLQATKEFHSRVTQMGTNDLQAHILLGSKGVDLPKLTQKL 72
            |..|:..|.:....| .|||:.:..:|..::...:|    .|:.:|..::.|.:|::||....|.
Worm    26 QTNRVGQENSQQFTVRNGVEQELCGILGGSEGDWTR----QTHSVQKQMMFGERGIELPSRQPKS 86

  Fly    73 ESLSARQTFEPIDPVTETNVQAYLKNERENAILSVIDETNRSIFKSVERQKWRCIYSEWGEEKEA 137
            .:.....|.|.:..|.|..:....:.|.:..|..|..||:|:.|..:...:...:
Worm    87 HTAEDTLTDEGVVDVPEAVMDDIDEEELDEDISRVKVETDRAFFNHMLLSRPAAV---------- 141

  Fly   138 LLNALVGPNQQDFPDVQFQIVPTAMADEPTPYSQLNGHEQMYAEQI--AIHNQSIILGRRPNLLS 200
            .:|......:.:.|....:.|...::|.         .|.::.:::  .:.||.     :.:|:.
Worm   142 PMNPAQAMERDNLPFGGGKFVNKNISDR---------RELIFGDKLHKFLKNQG-----KKSLVD 192

  Fly   201 TLAHVVQDSFNDESVAEMWNVLQFMTALPPVSSTIDPIKNRQTS---------PQFVEQARTYLE 256
            .:...:.:|..|.::.::||             .:..:.||:||         ...||.|..||:
Worm   193 LMKEAIDESGTDGALGDVWN-------------DVTSVLNRKTSASRDDLTTTANLVEDACKYLQ 244

  Fly   257 RRYRTYMRKFIVANLAKARRGGIPSVYHMVRSYVGVTLQGQRALYGLHDVNNGQPLWPHVYYSLR 321
            ..:..:|:..:..||..|.|||||....:|.:::.|..  :.:.....|..:|.|.|...|:.:|
Worm   245 AVFTEHMQTVVERNLEVAERGGIPGTRGLVNAFLKVGT--EESFQPEDDSIDGMPTWQVTYHCVR 307

  Fly   322 SGDMDAAALYLKESGTCPDLLTLLT----LRKNGDRDNLMVKLEGQLKLEYNSRLRACTDPYKKA 382
            :|||.:|:..|....:.|...||:.    :.|:|..|:   :|:.:||:|:...|....|.||:|
Worm   308 AGDMKSASETLNRLKSFPQCATLVAALNHVAKHGKLDS---ELKKKLKVEWRHNLAHTKDKYKRA 369

  Fly   383 VYVVLLACDPHFTHVELMRSIDDFLWMQLSILRRSDQSDSNTEQLTFSGLQSLILEKYGENYF-- 445
            :|..||.   ......|..::::::|.:|..|    ..|.....:.|..:|..:...|||.||
Worm   370 LYAALLG---GLDSAALADTLENWIWFKLYPL----HVDPQLTDVLFKEVQKAVSVDYGEQYFMS 427

  Fly   446 NAREKAALYFQVLTLTGQFEAAIEFLARTEKNRTHAIHMAIALNEISMLGTPRSVEQSLLSSDPD 510
            |...:...:|..|.|:||||.|| :|......|..::|:|:..:::..|...:.....:|..|.:
Worm   428 NGPSEFQYFFTALWLSGQFERAI-YLLHECGQRVDSVHVAVLAHKLGYLRMSKKSTDEMLVVDQN 491

  Fly   511 DPKPMKRLNLVRLIVMYTKCFERTDTTQALHYYYLLRNFKSENGRGNVMLTCVCDLLVEKCDDEM 575
            |.... .|||.||||.|||.||..|..::|.|::||:...:..|.....:.....:.:....||:
Worm   492 DSTKC-HLNLARLIVAYTKSFELVDVPRSLDYWFLLKGITTPTGSDVFEMAVSRSVYLTGQTDEI 555

  Fly   576 LELIFGTEDKKNGLRYGGIYAEFQIHECDKYSLAEMVGDELSKRGDYELAIELYFIGGQLDKALR 640
            |..:  |.|   |.|..|:..|:.   .|...:...|..:....|:::.|:.||.:..:...|..
Worm   556 LGKL--TPD---GRREKGLIDEYL---DDPSEVICRVASDTEITGEWDQAVGLYLLASKPTNAAI 612

  Fly   641 LVNSLLAQVVHQPTQNGSVRNRLGDIINRLDAALVVRKSDVEVQVVVTYTVLTKVMKFFDHYHEG 705
            |::|.:::.:.  |:|   :.::.|:::..:....|::. .:.....|.::|..:...|||....
Worm   613 LLSSEISETLR--TEN---KEKIADLVHVAEQFKKVQRG-CQASEYATLSLLVDLAVLFDHCRNE 671

  Fly   706 ALRSALEILTNNHLIPASSLEVDECVTNIKRMGPEVIKVLPDILLASMDIVYQEYVKL------M 764
            ....|..|.|:..|||....:|...|.....:..:|.:||||:.|..|..:....::.      .
Worm   672 EAEIAYGISTHLRLIPTEPDQVTVIVNEFHMVPQKVREVLPDMCLHLMKCLVDHCIRQSTTQANR 736

  Fly   765 DSNETASGFFDESKCVNKEPAVKHLRDRAKAFTNMAASVPYRMPSTTNQRLVQLE 819
            .:|...:..|..|....|:         .||....:|:|||:.|:....||:||:
Worm   737 GANSATTSMFSSSNRYVKQ---------IKAIVLYSATVPYKFPTHVTSRLLQLQ 782

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Nup93-1	NP_572929.1	Nic96	215..808	CDD:309288	151/613 (25%)
npp-13	NP_740802.1	Nic96	206..771	CDD:282017	151/614 (25%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C160163617
Domainoid	1	1.000	167	1.000	Domainoid score	I2332
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	1	1.000	-	-
Homologene	0	0.000	Not matched by this tool.
Inparanoid	1	1.050	188	1.000	Inparanoid score	I2582
Isobase	0	0.000	Not matched by this tool.
OMA	1	1.010	-	-		QHG59183
OrthoDB	1	1.010	-	-		D187731at2759
OrthoFinder	1	1.000	-	-		FOG0002723
OrthoInspector	1	1.000	-	-		otm14348
orthoMCL	1	0.900	-	-		OOG6_103333
Panther	1	1.100	-	-	O	PTHR11225
Phylome	1	0.910	-	-
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R780
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	12	11.940