DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Clic and Clic4

DIOPT Version :9

Sequence 1:	NP_001259537.2	Gene:	Clic / 32349	FlyBaseID:	FBgn0030529	Length:	260	Species:	Drosophila melanogaster
Sequence 2:	NP_114006.1	Gene:	Clic4 / 83718	RGDID:	61857	Length:	253	Species:	Rattus norvegicus

Alignment Length:	242	Identity:	75/242 - (30%)
Similarity:	119/242 - (49%)	Gaps:	28/242 - (11%)

- Green bases have known domain annotations that are detailed below.

  Fly     9 SQETNGSSKFD-VPEIELIIKASTIDGRRKGACLFCQEYFMDLYLLAELKTISLKVTTVDMQKPP 72
            |...||..:.| .|.|||.:||.: ||...|.|.|.|..||.|:    ||.:...|||||:::.|
  Rat     4 SMPLNGLKEEDKEPLIELFVKAGS-DGESIGNCPFSQRLFMILW----LKGVVFSVTTVDLKRKP 63

  Fly    73 PDFRTNFEATHPPILIDNGLAILENEKIERHIMKNI--PGGYNLFVQDKEVATLIENLYVK---- 131
            ...:.....||||.:..|.....:..|||..:.:.:  |....|..:..|..|...:::.|
  Rat    64 AHLQNLAPGTHPPFITFNSEVKTDVNKIEEFLEEVLCPPKYLKLSPKHPESNTAGMDIFAKFSAY 128

  Fly   132 LKLMLVKKDEAKNNALLSHLRKINDHLS----------------ARNTRFLTGDTMCCFDCELMP 180
            :|....:.:||....||..|:|::::|:                :...|||.||.|...||.|:|
  Rat   129 IKNSRPEANEALERGLLKTLQKLDEYLNSPLPGEIDENSMEDIKSSTRRFLDGDEMTLADCNLLP 193

  Fly   181 RLQHIRVAGKYFVDFEIPTHLTALWRYMYHMYQLDAFTQSCPADQDI 227
            :|..::|..|.:.:|:||..:|.:|||:.:.|..|.||.:||:|:::
  Rat   194 KLHIVKVVAKKYRNFDIPKGMTGIWRYLTNAYSRDEFTNTCPSDKEV 240

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Clic	NP_001259537.2	GST_N_CLIC	18..112	CDD:239359	33/96 (34%)
		O-ClC	21..231	CDD:129941	71/229 (31%)
		GST_C_CLIC	118..232	CDD:198307	38/130 (29%)
Clic4	NP_114006.1	Required for insertion into the membrane. /evidence=ECO:0000250	2..101		35/101 (35%)
		GST_N_CLIC	14..104	CDD:239359	33/94 (35%)
		O-ClC	17..252	CDD:129941	71/229 (31%)
		GST_C_family	111..251	CDD:295467	38/130 (29%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C166347862
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	1	1.000	-	-
Homologene	0	0.000	Not matched by this tool.
Inparanoid	1	1.050	119	1.000	Inparanoid score	I4688
OMA	1	1.010	-	-		QHG57946
OrthoDB	1	1.010	-	-		D541338at33208
OrthoFinder	1	1.000	-	-		FOG0000394
OrthoInspector	1	1.000	-	-		otm45221
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	O	PTHR43920
Phylome	1	0.910	-	-
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
	10	10.010