DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Clic and clic4

DIOPT Version :9

Sequence 1:	NP_001259537.2	Gene:	Clic / 32349	FlyBaseID:	FBgn0030529	Length:	260	Species:	Drosophila melanogaster
Sequence 2:	NP_001007908.1	Gene:	clic4 / 493290	XenbaseID:	XB-GENE-958154	Length:	252	Species:	Xenopus tropicalis

Alignment Length:	227	Identity:	74/227 - (32%)
Similarity:	113/227 - (49%)	Gaps:	27/227 - (11%)

- Green bases have known domain annotations that are detailed below.

  Fly    23 IELIIKASTIDGRRKGACLFCQEYFMDLYLLAELKTISLKVTTVDMQKPPPDFRTNFEATHPPIL 87
            :||.:||.: ||...|.|.|.|..||.|:    ||.:...|||||:::.|.|.:.....||||.:
Frog    18 VELFVKAGS-DGESIGNCPFSQRLFMILW----LKGVVFNVTTVDLKRKPADLQNLAPGTHPPFI 77

  Fly    88 IDNGLAILENEKIERHIMKNI-PGGY-NLFVQDKEVATLIENLYVK----LKLMLVKKDEAKNNA 146
            ..|.....:..|||..:.:.: |..| .|..:..|..|...:::.|    :|......:||....
Frog    78 TYNHEVKTDVNKIEEFLEEVLCPPKYRKLAAKHPESNTAGMDIFAKFSAYIKNSRPDNNEALERG 142

  Fly   147 LLSHLRKINDHLSA----------------RNTRFLTGDTMCCFDCELMPRLQHIRVAGKYFVDF 195
            ||..|:|::|:|::                .|.:||.|:.|...||.|:|:|..|:|..|.:..|
Frog   143 LLKTLQKLDDYLNSPLPDEIDENSMDDITQSNRKFLDGEEMTLADCNLLPKLHIIKVVTKKYRGF 207

  Fly   196 EIPTHLTALWRYMYHMYQLDAFTQSCPADQDI 227
            |||..:|.:|||:.:.|..|.||.:||.|::|
Frog   208 EIPKSMTGIWRYLSNAYSKDEFTNTCPGDREI 239

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Clic	NP_001259537.2	GST_N_CLIC	18..112	CDD:239359	31/89 (35%)
		O-ClC	21..231	CDD:129941	74/227 (33%)
		GST_C_CLIC	118..232	CDD:198307	41/130 (32%)
clic4	NP_001007908.1	O-ClC	17..250	CDD:129941	74/227 (33%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	1	1.000	-	-
Homologene	0	0.000	Not matched by this tool.
Inparanoid	1	1.050	108	1.000	Inparanoid score	I4764
OMA	1	1.010	-	-		QHG57946
OrthoDB	1	1.010	-	-		D541338at33208
OrthoFinder	1	1.000	-	-		FOG0000394
OrthoInspector	1	1.000	-	-		otm48288
Panther	1	1.100	-	-	O	PTHR43920
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	8	8.080