DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Clic and clic5b

DIOPT Version :9

Sequence 1:	NP_001259537.2	Gene:	Clic / 32349	FlyBaseID:	FBgn0030529	Length:	260	Species:	Drosophila melanogaster
Sequence 2:	NP_998062.1	Gene:	clic5b / 405833	ZFINID:	ZDB-GENE-040426-2542	Length:	408	Species:	Danio rerio

Alignment Length:	245	Identity:	76/245 - (31%)
Similarity:	121/245 - (49%)	Gaps:	27/245 - (11%)

- Green bases have known domain annotations that are detailed below.

  Fly     9 SQETNGSSKFDVPEIELIIKASTIDGRRKGACLFCQEYFMDLYLLAELKTISLKVTTVDMQKPPP 73
            ::||...:..:.|::.|.:||.: ||...|.|.|.|..||.|:    ||.:...|||||:::.|.
Zfish   160 AEETTEVADPNQPQVALFVKAGS-DGESIGNCPFSQRLFMILW----LKGVVFNVTTVDLKRKPA 219

  Fly    74 DFRTNFEATHPPILIDNGLAILENEKIERHIMKNI-PGGY-NLFVQDKEVATLIENLYVKLKLML 136
            |.......||||.|..||....:..|||..:.:.: |..| .|..:.:|......:::.|....:
Zfish   220 DLHNLAPGTHPPFLTFNGEVKTDVNKIEEFLEEVLAPPKYPKLAARHRESNAAGNDIFAKFSAFI 284

  Fly   137 --VKKD--EAKNNALLSHLRKINDHLS----------------ARNTRFLTGDTMCCFDCELMPR 181
              .|.|  ||....|...|:|::::|:                |.|.|||.|:.:...||.|:|:
Zfish   285 KNTKPDANEALEKGLTKALKKLDEYLNSPLPDEVDADSMEEEKASNRRFLDGNDLTLADCNLLPK 349

  Fly   182 LQHIRVAGKYFVDFEIPTHLTALWRYMYHMYQLDAFTQSCPADQDIINHY 231
            |..::|..|.:.:|:||:.||.:|||:...|..:.||.:|.||.:|.:.|
Zfish   350 LHIVKVVAKKYRNFDIPSDLTGVWRYLNSAYAQEEFTNTCAADNEIESAY 399

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Clic	NP_001259537.2	GST_N_CLIC	18..112	CDD:239359	33/94 (35%)
		O-ClC	21..231	CDD:129941	73/231 (32%)
		GST_C_CLIC	118..232	CDD:198307	39/134 (29%)
clic5b	NP_998062.1	GST_N_CLIC	170..259	CDD:239359	33/93 (35%)
		O-ClC	172..407	CDD:129941	74/233 (32%)
		GST_C_CLIC5	266..406	CDD:198330	39/134 (29%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C170589763
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	1	1.000	-	-
Homologene	0	0.000	Not matched by this tool.
Inparanoid	1	1.050	120	1.000	Inparanoid score	I4748
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D541338at33208
OrthoFinder	1	1.000	-	-		FOG0000394
OrthoInspector	1	1.000	-	-		otm24777
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R2518
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
ZFIN	0	0.000	Not matched by this tool.
	8	7.930