DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Clic and Clic6

DIOPT Version :9

Sequence 1:	NP_001259537.2	Gene:	Clic / 32349	FlyBaseID:	FBgn0030529	Length:	260	Species:	Drosophila melanogaster
Sequence 2:	NP_788267.2	Gene:	Clic6 / 304081	RGDID:	727938	Length:	613	Species:	Rattus norvegicus

Alignment Length:	234	Identity:	77/234 - (32%)
Similarity:	117/234 - (50%)	Gaps:	31/234 - (13%)

- Green bases have known domain annotations that are detailed below.

  Fly    22 EIELIIKASTIDGRRKGACLFCQEYFMDLYLLAELKTISLKVTTVDMQKPPPDFRTNFEATHPPI 86
            :|.|.:||.: ||...|.|.|.|..||.|:    ||.:...|||||:::.|.|.:.....|:||.
  Rat   379 DITLFVKAGS-DGESIGNCPFSQRLFMILW----LKGVIFNVTTVDLKRKPADLQNLAPGTNPPF 438

  Fly    87 LIDNGLAILENEKIERHI-MKNIPGGY-NLFVQDKEVATLIENLYVKLKLML--VKKDE----AK 143
            :..:|....:..|||..: .|.:|..| .|..|..|..:...:::.|....:  .|||.    .|
  Rat   439 MTFDGEVKTDVNKIEEFLEEKLVPPRYPKLGTQHPESNSAGNDVFAKFSAFIKNTKKDANDIYEK 503

  Fly   144 NNALLSHLRKIN--------DHLSARNT--------RFLTGDTMCCFDCELMPRLQHIRVAGKYF 192
            |  ||..|:|::        |.:.|.:|        :||.||.:...||.|:|:|..|::..|.:
  Rat   504 N--LLRALKKLDSYLNSPLPDEIDAYSTEDVTVSQRKFLDGDELTLADCNLLPKLHIIKIVAKKY 566

  Fly   193 VDFEIPTHLTALWRYMYHMYQLDAFTQSCPADQDIINHY 231
            ..||.|:.:|.:|||:.:.|..|.||.:|||||:|.:.|
  Rat   567 RGFEFPSEMTGIWRYLNNAYARDEFTNTCPADQEIEHAY 605

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Clic	NP_001259537.2	GST_N_CLIC	18..112	CDD:239359	31/90 (34%)
		O-ClC	21..231	CDD:129941	76/232 (33%)
		GST_C_CLIC	118..232	CDD:198307	43/136 (32%)
Clic6	NP_788267.2	2A1904	<51..318	CDD:273344
Clic6	NP_788267.2	O-ClC	380..613	CDD:129941	77/233 (33%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C166348034
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D541338at33208
OrthoFinder	1	1.000	-	-		FOG0000394
OrthoInspector	1	1.000	-	-		otm45221
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
	6	5.850