Protein Alignment Clic and CLIC4

DIOPT Version :9

• Sequence 1: NP_001259537.2
• Gene: Clic / 32349
• FlyBaseID: FBgn0030529
• Length: 260
• Species: Drosophila melanogaster
• Sequence 2: NP_039234.1
• Gene: CLIC4 / 25932
• HGNCID: 13518
• Length: 253
• Species: Homo sapiens
• Alignment Length: 242
• Identity: 74/242 - (30%)
• Similarity: 120/242 - (49%)
• Gaps: 28/242 - (11%)

  Fly     9 SQETNGSSKFD-VPEIELIIKASTIDGRRKGACLFCQEYFMDLYLLAELKTISLKVTTVDMQKPP 72
            |...||..:.| .|.|||.:||.: ||...|.|.|.|..||.|:    ||.:...|||||:::.|
Human     4 SMPLNGLKEEDKEPLIELFVKAGS-DGESIGNCPFSQRLFMILW----LKGVVFSVTTVDLKRKP 63

  Fly    73 PDFRTNFEATHPPILIDNGLAILENEKIERHIMKNI--PGGYNLFVQDKEVATLIENLYVK---- 131
            .|.:.....||||.:..|.....:..|||..:.:.:  |....|..:..|..|...:::.|
Human    64 ADLQNLAPGTHPPFITFNSEVKTDVNKIEEFLEEVLCPPKYLKLSPKHPESNTAGMDIFAKFSAY 128

  Fly   132 LKLMLVKKDEAKNNALLSHLRKINDHLSA----------------RNTRFLTGDTMCCFDCELMP 180
            :|....:.:||....||..|:|::::|::                ...:||.|:.|...||.|:|
Human   129 IKNSRPEANEALERGLLKTLQKLDEYLNSPLPDEIDENSMEDIKFSTRKFLDGNEMTLADCNLLP 193

  Fly   181 RLQHIRVAGKYFVDFEIPTHLTALWRYMYHMYQLDAFTQSCPADQDI 227
            :|..::|..|.:.:|:||..:|.:|||:.:.|..|.||.:||:|:::
Human   194 KLHIVKVVAKKYRNFDIPKEMTGIWRYLTNAYSRDEFTNTCPSDKEV 240

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Clic	NP_001259537.2	GST_N_CLIC	18..112	CDD:239359	34/96 (35%)
		O-ClC	21..231	CDD:129941	70/229 (31%)
		GST_C_CLIC	118..232	CDD:198307	36/130 (28%)
CLIC4	NP_039234.1	Required for insertion into the membrane. /evidence=ECO:0000305	2..101		36/101 (36%)
		O-ClC	17..252	CDD:129941	70/229 (31%)

Information from Original Tools

Tool	Simple Score	Weighted Score	Original Tool Information
			BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C165154246
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	1	1.000	-	-
Homologene	0	0.000	Not matched by this tool.
Inparanoid	1	1.050	119	1.000	Inparanoid score	I4781
Isobase	1	0.950	-	0	Normalized mean entropy	S6054
OMA	1	1.010	-	-		QHG57946
OrthoDB	1	1.010	-	-		D541338at33208
OrthoFinder	1	1.000	-	-		FOG0000394
OrthoInspector	1	1.000	-	-		otm41081
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	O	PTHR43920
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	11	10.960