Protein Alignment Clic and CLIC2

DIOPT Version :10

• Sequence 1: NP_572928.1
• Gene: Clic / 32349
• FlyBaseID: FBgn0030529
• Length: 260
• Species: Drosophila melanogaster
• Sequence 2: NP_001280.3
• Gene: CLIC2 / 1193
• HGNCID: 2063
• Length: 247
• Species: Homo sapiens
• Alignment Length: 233
• Identity: 78/233 - (33%)
• Similarity: 120/233 - (51%)
• Gaps: 27/233 - (11%)

  Fly    21 PEIELIIKASTIDGRRKGACLFCQEYFMDLYLLAELKTISLKVTTVDMQKPPPDFRTNFEATHPP 85
            |||||.:||.: ||...|.|.|||..||.|:    ||.:...||||||.:.|.:.:.....|:||
Human    12 PEIELFVKAGS-DGESIGNCPFCQRLFMILW----LKGVKFNVTTVDMTRKPEELKDLAPGTNPP 71

  Fly    86 ILIDNGLAILENEKIERHIMKNI-PGGY-NLFVQDKEVATLIENLYVKLKLML--VKKDEAKN-- 144
            .|:.|.....:..|||..:.:.: |..| :|..:.||...:..||:.|....:  .:|:..||
Human    72 FLVYNKELKTDFIKIEEFLEQTLAPPRYPHLSPKYKESFDVGCNLFAKFSAYIKNTQKEANKNFE 136

  Fly   145 NALLSHLRKINDHLS----------------ARNTRFLTGDTMCCFDCELMPRLQHIRVAGKYFV 193
            .:||...::::|:|:                .....||.||.:...||.|:|:|..|:||.|.:.
Human   137 KSLLKEFKRLDDYLNTPLLDEIDPDSAEEPPVSRRLFLDGDQLTLADCSLLPKLNIIKVAAKKYR 201

  Fly   194 DFEIPTHLTALWRYMYHMYQLDAFTQSCPADQDIINHY 231
            ||:||...:.:|||:::.|..:.||.:||.|::|.|.|
Human   202 DFDIPAEFSGVWRYLHNAYAREEFTHTCPEDKEIENTY 239

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Clic	NP_572928.1	GST_N_CLIC	18..112	CDD:239359	35/91 (38%)
		GST_C_CLIC	118..232	CDD:198307	41/134 (31%)
CLIC2	NP_001280.3	Required for insertion into the membrane. /evidence=ECO:0000250	1..96		34/88 (39%)
		N-terminal	1..94		34/86 (40%)
		O-ClC	12..245	CDD:129941	78/233 (33%)
		G-site. /evidence=ECO:0000305|PubMed:25581026	30..33		1/2 (50%)
		Joint loop	95..106		3/10 (30%)
		C-terminal	107..247		41/133 (31%)
		Foot loop	151..171		0/19 (0%)