DRSC/TRiP Functional Genomics Resources

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Protein Alignment Clic and CLIC2

DIOPT Version :9

Sequence 1:NP_001259537.2 Gene:Clic / 32349 FlyBaseID:FBgn0030529 Length:260 Species:Drosophila melanogaster
Sequence 2:NP_001280.3 Gene:CLIC2 / 1193 HGNCID:2063 Length:247 Species:Homo sapiens


Alignment Length:233 Identity:78/233 - (33%)
Similarity:120/233 - (51%) Gaps:27/233 - (11%)


- Green bases have known domain annotations that are detailed below.


  Fly    21 PEIELIIKASTIDGRRKGACLFCQEYFMDLYLLAELKTISLKVTTVDMQKPPPDFRTNFEATHPP 85
            |||||.:||.: ||...|.|.|||..||.|:    ||.:...||||||.:.|.:.:.....|:||
Human    12 PEIELFVKAGS-DGESIGNCPFCQRLFMILW----LKGVKFNVTTVDMTRKPEELKDLAPGTNPP 71

  Fly    86 ILIDNGLAILENEKIERHIMKNI-PGGY-NLFVQDKEVATLIENLYVKLKLML--VKKDEAKN-- 144
            .|:.|.....:..|||..:.:.: |..| :|..:.||...:..||:.|....:  .:|:..||  
Human    72 FLVYNKELKTDFIKIEEFLEQTLAPPRYPHLSPKYKESFDVGCNLFAKFSAYIKNTQKEANKNFE 136

  Fly   145 NALLSHLRKINDHLS----------------ARNTRFLTGDTMCCFDCELMPRLQHIRVAGKYFV 193
            .:||...::::|:|:                .....||.||.:...||.|:|:|..|:||.|.:.
Human   137 KSLLKEFKRLDDYLNTPLLDEIDPDSAEEPPVSRRLFLDGDQLTLADCSLLPKLNIIKVAAKKYR 201

  Fly   194 DFEIPTHLTALWRYMYHMYQLDAFTQSCPADQDIINHY 231
            ||:||...:.:|||:::.|..:.||.:||.|::|.|.|
Human   202 DFDIPAEFSGVWRYLHNAYAREEFTHTCPEDKEIENTY 239

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
ClicNP_001259537.2 GST_N_CLIC 18..112 CDD:239359 35/91 (38%)
O-ClC 21..231 CDD:129941 77/231 (33%)
GST_C_CLIC 118..232 CDD:198307 41/134 (31%)
CLIC2NP_001280.3 Required for insertion into the membrane. /evidence=ECO:0000250 1..96 34/88 (39%)
N-terminal 1..94 34/86 (40%)
O-ClC 12..245 CDD:129941 78/233 (33%)
Joint loop 95..106 3/10 (30%)
C-terminal 107..247 41/133 (31%)
Foot loop 151..171 0/19 (0%)


Information from Original Tools:


Tool Simple Score Weighted Score Original Tool Information
BLAST Result Score Score Type Cluster ID
Compara 1 0.930 - - C165154414
Domainoid 00.000 Not matched by this tool.
eggNOG 00.000 Not matched by this tool.
Hieranoid 1 1.000 - -
Homologene 00.000 Not matched by this tool.
Inparanoid 1 1.050 119 1.000 Inparanoid score I4781
Isobase 1 0.950 - 0 Normalized mean entropy S6054
OMA 1 1.010 - - QHG57946
OrthoDB 1 1.010 - - D541338at33208
OrthoFinder 1 1.000 - - FOG0000394
OrthoInspector 1 1.000 - - otm41081
orthoMCL 1 0.900 - - OOG6_107975
Panther 1 1.100 - - O PTHR43920
Phylome 1 0.910 - -
RoundUp 1 1.030 - avgDist Average_Evolutionary_Distance R2518
SonicParanoid 00.000 Not matched by this tool.
SwiftOrtho 00.000 Not matched by this tool.
TreeFam 00.000 Not matched by this tool.
User_Submission 00.000 Not matched by this tool.
1211.890

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