Protein Alignment Clic and CLIC1

DIOPT Version :9

• Sequence 1: NP_001259537.2
• Gene: Clic / 32349
• FlyBaseID: FBgn0030529
• Length: 260
• Species: Drosophila melanogaster
• Sequence 2: NP_001274522.1
• Gene: CLIC1 / 1192
• HGNCID: 2062
• Length: 241
• Species: Homo sapiens
• Alignment Length: 241
• Identity: 61/241 - (25%)
• Similarity: 111/241 - (46%)
• Gaps: 28/241 - (11%)

  Fly    21 PEIELIIKASTIDGRRKGACLFCQEYFMDLYLLAELKTISLKVTTVDMQKPPPDFRTNFEATHPP 85
            |::||.:||.: ||.:.|.|.|.|..||.|:    ||.::..|||||.::.....:........|
Human     6 PQVELFVKAGS-DGAKIGNCPFSQRLFMVLW----LKGVTFNVTTVDTKRRTETVQKLCPGGQLP 65

  Fly    86 ILIDNGLAILENEKIERHIMKNI-PGGY-NLFVQDKEVATLIENLYVKLKLMLVKKDEAKNN--- 145
            .|:.......:..|||..:...: |..| .|...:.|..|...:::.|....:...:.|.|:
Human    66 FLLYGTEVHTDTNKIEEFLEAVLCPPRYPKLAALNPESNTAGLDIFAKFSAYIKNSNPALNDNLE 130

  Fly   146 -ALLSHLRKINDHLSA----------------RNTRFLTGDTMCCFDCELMPRLQHIRVAGKYFV 193
             .||..|:.::::|::                ...:||.|:.:...||.|:|:|..::|..|.:.
Human   131 KGLLKALKVLDNYLTSPLPEEVDETSAEDEGVSQRKFLDGNELTLADCNLLPKLHIVQVVCKKYR 195

  Fly   194 DFEIPTHLTALWRYMYHMYQLDAFTQSCPADQDI-INHYKLQQSLK 238
            .|.||.....:.||:.:.|..:.|..:||.|::| :.:.::.::||
Human   196 GFTIPEAFRGVHRYLSNAYAREEFASTCPDDEEIELAYEQVAKALK 241

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Clic	NP_001259537.2	GST_N_CLIC	18..112	CDD:239359	27/91 (30%)
		O-ClC	21..231	CDD:129941	59/232 (25%)
		GST_C_CLIC	118..232	CDD:198307	30/134 (22%)
CLIC1	NP_001274522.1	Required for insertion into the membrane	2..90		26/88 (30%)
		O-ClC	6..241	CDD:129941	59/239 (25%)

Information from Original Tools

Tool	Simple Score	Weighted Score	Original Tool Information
			BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C165154552
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	1	1.000	-	-
Homologene	0	0.000	Not matched by this tool.
Inparanoid	1	1.050	119	1.000	Inparanoid score	I4781
Isobase	0	0.000	Not matched by this tool.
OMA	1	1.010	-	-		QHG57946
OrthoDB	1	1.010	-	-		D541338at33208
OrthoFinder	1	1.000	-	-		FOG0000394
OrthoInspector	1	1.000	-	-		otm41081
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	O	PTHR43920
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	9	9.010