DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment inaE and daglb

DIOPT Version :9

Sequence 1:	NP_001138195.1	Gene:	inaE / 32343	FlyBaseID:	FBgn0261244	Length:	1318	Species:	Drosophila melanogaster
Sequence 2:	XP_009304651.1	Gene:	daglb / 565287	ZFINID:	ZDB-GENE-070619-2	Length:	668	Species:	Danio rerio

Alignment Length:	725	Identity:	235/725 - (32%)
Similarity:	375/725 - (51%)	Gaps:	113/725 - (15%)

- Green bases have known domain annotations that are detailed below.

  Fly     1 MPGLVVFRRRWSVGSDDLVVPGAFLLTIHFICFVIVSVSLVIFEYNTRILSVKLLFYHLIGYLLI 65
            ||||:||.|||.:.|||||.||||.|.|..:.::   |:||::..:......|...| |..|||:
Zfish     1 MPGLLVFGRRWRIASDDLVFPGAFELFIRAVWWI---VTLVVYTNHKGSFDCKGGAY-LQYYLLV 61

  Fly    66 LFFSICVEI----GICVISMRGSILDAEARTSINIWIYLKSLVILFDIAWLAVGSVWLGHYYTTA 126
            |.|.:.|.|    .|..:|.:|:|::...|.|:.:.:||::::...:..|..:|:||:....:..
Zfish    62 LLFLLAVIILTLCAIVYVSAQGTIMNQGPRRSMPLLVYLRAVLYFPEFVWACLGAVWVSDNSSGC 126

  Fly   127 PIDDPKKV--YIAIIICNWALVVITLITIWCTFDAAGRSWVKMKKYQRSMRETESRFNYKRSNSM 189
               .|::|  .|..::.:|.:::...:.:...||..|....     .|.:|:.:|..:.:..:|
Zfish   127 ---QPEEVGAVIGAVVSSWVILLAMAVGVLVVFDPLGSPGP-----SRGLRDLQSSESSQLFSS- 182

  Fly   190 NRNWRQRKVMRAYQDSWDHRCRLLFCCMGSSERNRNSFTDIARLLSDFFRELDVVPSDVVAGLVL 254
                .|....|.    |::|.|||.||:...:.:|.:|:.||:|:|.||.:.|:||||:.|||.|
Zfish   183 ----AQSVASRV----WENRLRLLCCCLPQDDNHRAAFSSIAQLVSGFFMDTDLVPSDIAAGLAL 239

  Fly   255 LRKFQ-RLER-----EAIVRQRKNGTYEFLSGVPITERTQFLALNDAKNYDFFQTV---IHYMYF 310
            |.:.| ::|:     |.:.....:         ||.|             |..|.:   .|||.|
Zfish   240 LHQEQDKMEQCRDPDEVLTHSPSS---------PIRE-------------DLEQELEKSAHYMQF 282

  Fly   311 AQGAYGWPMYVIINRSKMWHLVPELKCFGCCCGTSD-DTEVIQDNCCLCNYAALKKTLQLGDIDI 374
            |..|||||:||..|     .|....|..|.|||:.. :.:::..:...|::.::.::..|...|.
Zfish   283 AAAAYGWPLYVYSN-----PLTGVCKLSGDCCGSRHAEYDLVGGDALGCHFTSILQSTGLQYRDF 342

  Fly   375 VYATYHVDVGETPFFVAIDYTHRAVVISIRGTLSMKDILTDLNAEGEVLPLQPPRDDWLGHKGMV 439
            ::.::|..:.|.|||||:|:...||::::|||||:||:||||:||.|.|.::........|||:.
Zfish   343 IHISFHNQIYEVPFFVALDHKREAVLVAVRGTLSLKDVLTDLSAECENLSVEGVSGSCYAHKGIS 407

  Fly   440 QAAIYIRNKLQEENLIERALQRNPDRQTHTFDLVLVGHSLGAGTAAILAILLKPEHPTLQCFSYS 504
            |||.:|..:|..:.::.:|....|:     :.||:.|||||||||::||:||....|||:|:::|
Zfish   408 QAAHFIYKRLVHDGILSQAFSIAPE-----YKLVVTGHSLGAGTASLLAVLLHSSQPTLECYAFS 467

  Fly   505 PPGGLLSMPAVEYSKSFITSVVLGKDVVPRIGLNQMEALRADLINAIQRSVDPKWKTISCSVICC 569
            |||||:|....::||.|:.||:||||:|||:.:..||.|:..|:..:.....||::     ::..
Zfish   468 PPGGLMSKALADFSKQFVVSVILGKDLVPRLSIPNMEDLKRRLLKMVSNCSKPKYQ-----ILLQ 527

  Fly   570 GCGPEPTSVVNMSGQD--THINQYQEERGT-----ARSTSAHP--------TDSSIALTLHQPLY 619
            ||..|   |...|..|  |.:...:||..:     |...||.|        :|.|.....|.|||
Zfish   528 GCWYE---VFGGSPDDSPTELESRREEELSRPLLGAECVSAAPSSSYQSLSSDDSPVQNTHLPLY 589

  Fly   620 PPGRIIHIVRHHPKPDEQKYDSGWRNVLKNREPV-----YQAIWADSTDFDEVLISPVMLQDHMP 679
            .|||::::....|                :|.|.     |:|.|:....|..|:|||.|::||||
Zfish   590 LPGRVLYVTEDGP----------------SRRPCFSQVRYRAEWSSEASFRNVMISPKMIKDHMP 638

  Fly   680 DKVLAALKKV 689
            |.||.||:.:
Zfish   639 DVVLRALQSL 648

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
inaE	NP_001138195.1	Lipase_3	300..542	CDD:238287	97/245 (40%)
daglb	XP_009304651.1	Lipase_3	272..499	CDD:238287	95/236 (40%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_KOG2088
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D191418at2759
OrthoFinder	1	1.000	-	-		FOG0001980
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	1	0.900	-	-		OOG6_102001
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R3340
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
ZFIN	0	0.000	Not matched by this tool.
	6	5.750