DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment inaE and Dagla

DIOPT Version :9

Sequence 1:	NP_001138195.1	Gene:	inaE / 32343	FlyBaseID:	FBgn0261244	Length:	1318	Species:	Drosophila melanogaster
Sequence 2:	NP_001005886.1	Gene:	Dagla / 309207	RGDID:	1359461	Length:	1044	Species:	Rattus norvegicus

Alignment Length:	1133	Identity:	382/1133 - (33%)
Similarity:	566/1133 - (49%)	Gaps:	173/1133 - (15%)

- Green bases have known domain annotations that are detailed below.

  Fly     1 MPGLVVFRRRWSVGSDDLVVPGAFLLTIHFICFVIVSVSLVIFEYNTRILSVKLLFYHLIGYLLI 65
            |||:|||||||||||||||:|..||..:|...|||:||.|....||........|..|..|||.|
  Rat     1 MPGIVVFRRRWSVGSDDLVLPAIFLFLLHTTWFVILSVVLFGLVYNPHEACSLNLVDHGRGYLGI 65

  Fly    66 LFFSICVEIGICVISMRGSILDAEARTSINIWIYLKSLVILFDIAWLAVGSVWLGHYYTTAPIDD 130
            |...:..|:.|..:||||.||..|.|.|:...:|::..:::.:..:..||.|||..|||:.....
  Rat    66 LLSCMIAEMAIIWLSMRGGILYTEPRDSMQYVLYVRLAILVIEFIYAIVGIVWLTQYYTSCNDLT 130

  Fly   131 PKKVYIAIIICNWALVVITLITIWCTFDAAGRSWVKMKKYQRSMRETESRFNYKRSNSMNRNWRQ 195
            .|.|.:.:::|||.:::...||:.|.||..||::||::..:|..|           |....|.|.
  Rat   131 AKNVTLGMVVCNWVVILSVCITVLCVFDPTGRTFVKLRATKRRQR-----------NLRTYNLRH 184

  Fly   196 RKVMRAYQDSWDHRCRLLFCCMGSSERNRNSFTDIARLLSDFFRELDVVPSDVVAGLVLLRKFQR 260
            | :......||..|.::..||..:.:...:::::||.|.::|||:||:||||::|||||||:.||
  Rat   185 R-LEEGQATSWSRRLKVFLCCTRTKDSQSDAYSEIAYLFAEFFRDLDIVPSDIIAGLVLLRQRQR 248

  Fly   261 LEREAIVRQRKNGTYEFLSGVPITERTQFLALNDAKNYDFFQTVIHYMYFAQGAYGWPMYVIINR 325
            .:|.|::.:..|....||||:|:|..|::|.|.::.....::.|.:||.||..|||||||::  |
  Rat   249 AKRNAVLDEANNDILAFLSGMPVTRNTKYLDLKNSHEMLRYKEVCYYMLFALAAYGWPMYLM--R 311

  Fly   326 SKMWHLVPELKCFGCC-CGT----SDDTEVIQDNCCLCNYAALKKTL---QLGDIDIVYATYHVD 382
            .....|....:...|| |..    :....:.:||||.||..|:::..   .:..:||||.:.|..
  Rat   312 KPTCGLCQLARSCSCCLCPARPRFAPGVTIEEDNCCGCNAIAIRRHFLDENMTAVDIVYTSCHDA 376

  Fly   383 VGETPFFVAIDYTHRAVVISIRGTLSMKDILTDLNAEGEVLPLQPPRDDWLGHKGMVQAAIYIRN 447
            |.||||:||:|:..:.||||||||||.||.||||..:.|.||::..|..||||||||.:|.||:.
  Rat   377 VYETPFYVAVDHDKKKVVISIRGTLSPKDALTDLTGDAERLPVEGHRGTWLGHKGMVLSAEYIKK 441

  Fly   448 KLQEENLIERALQRNPDRQTHTFDLVLVGHSLGAGTAAILAILLKPEHPTLQCFSYSPPGGLLSM 512
            ||::|.::.:|..|:..|.|..:.|::|||||||||||||:.||:|::|||:||:|||||||||.
  Rat   442 KLEQEMVLSQAFGRDLGRGTKHYGLIVVGHSLGAGTAAILSFLLRPQYPTLKCFAYSPPGGLLSE 506

  Fly   513 PAVEYSKSFITSVVLGKDVVPRIGLNQMEALRADLINAIQRSVDPKWKTISCSVICCGCGPEPTS 577
            .|:||||.|:|:||||||:||||||:|:|..|..|::.:|||..|||:.|..:..|......|..
  Rat   507 DAMEYSKEFVTAVVLGKDLVPRIGLSQLEGFRRQLLDVLQRSTKPKWRIIVGATKCIPKSELPED 571

  Fly   578 VVNMSGQDTHINQYQEERGTARSTS---AHPTDSSIALTLHQPLYPPGRIIHIVRHHPKPD---- 635
            .|.:               ||.:::   .||:|.:|||:...||||||||||:|.:||...
  Rat   572 QVEV---------------TALASTRLWTHPSDLTIALSASTPLYPPGRIIHVVHNHPAEQCCCC 621

  Fly   636 EQKYDSGWRNVLKNREPVYQAIWADSTDFDEVLISPVMLQDHMPDKVLAALKKVVTTSGPRKPQR 700
            ||:            ||.|.|||.|:..|:||:|||.||.:|:|..|:..|.||:
  Rat   622 EQE------------EPTYFAIWGDNKAFNEVIISPAMLHEHLPYVVMEGLNKVL---------- 664

  Fly   701 QTSNAFSTGSNEAAH------DMDLEP-------PHCSGHSAPTDAMRFETRTDPGQMQNSMSQS 752
            :..|...|....||.      ::||.|       |..:|...|| .:..|......:..:..|:|
  Rat   665 ENYNKGKTALLSAAKVMVSPTEVDLTPELIFQQQPLPTGPPLPT-GLALELPATEHRNSSVRSKS 728

  Fly   753 QHCKRLSQSSYTNLSNCLVLTPTA-----------------QHKLCLETSFTNGSTPHQSGVQPN 800
            |     |:.|....|...:|:|.|                 |.:|..|..              :
  Rat   729 Q-----SEMSLEGFSEGRLLSPVAAASAARQDPVELLLLSTQERLAAELQ--------------S 774

  Fly   801 PRLTSAASSLLSSATTPYDISSALDDSLATVALRQSPSL---ISAETTATVIVNPEPDAEEIAIP 862
            .|...|....||...:.|...|.......::  |.||||   :..:......::|....|..::.
  Rat   775 RRAPLATMESLSDTESLYSFDSRRSSGFRSI--RGSPSLHAVLERDEGHLFYIDPAIPEENPSLS 837

  Fly   863 QRLKAVAFD-MALTPPPTLPERSMLGRQH-SEKKPRSLPLAQVQALRRASDAGAVPGVDL-LHDD 924
            .|.:.:|.| ::.....|.|..:.||... :.::|.|....:.:|...:...|..|..:| ||:.
  Rat   838 SRTELLAADSLSKHSQDTQPLEAALGSGGVTPERPPSAANDEEEAAGGSEGGGVAPRGELALHNG 902

  Fly   925 WYGLAPLASPETL------SEISSVSSRTS---------VPISLANSIERYLQHMGVGVGGPKVP 974
            ..|.:|  ||:.|      ..:.::.|::|         ||.|..:.   |.:       |||.|
  Rat   903 RLGDSP--SPQVLEFAEFIDSLFNLDSKSSSFQDLYCMMVPESPTSD---YTE-------GPKSP 955

  Fly   975 --LEDIFESQLHTPKVMRRAPKFSENLAGCAEDTRNLDQYKRLGRVFITFPRIFPDQSPAAHSLD 1037
              .|.:..:|.. |.::.:.|:.   .||.||.:..           |:....|| .|.:...:|
  Rat   956 SQQEILLRAQFE-PNLVPKPPRL---FAGSAEPSSG-----------ISLSPSFP-LSSSGELMD 1004

  Fly  1038 SSDDSFESASAHSLQRLQLP----HGAN 1061
            .:.....|....:..:::..    |||:
  Rat  1005 LTPTGLSSQECLATDKIRTSTPTGHGAS 1032

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
inaE	NP_001138195.1	Lipase_3	300..542	CDD:238287	126/249 (51%)
Dagla	NP_001005886.1	Lipase_3	288..529	CDD:238287	121/242 (50%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	848..905		12/56 (21%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	1013..1044		3/20 (15%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	1	1.000	278	1.000	Domainoid score	I1643
eggNOG	1	0.900	-	-		E1_KOG2088
Hieranoid	1	1.000	-	-
Homologene	0	0.000	Not matched by this tool.
Inparanoid	1	1.050	550	1.000	Inparanoid score	I1095
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D191418at2759
OrthoFinder	1	1.000	-	-		FOG0001980
OrthoInspector	1	1.000	-	-		oto98179
orthoMCL	1	0.900	-	-		OOG6_102001
Panther	1	1.100	-	-	LDO	PTHR45792
Phylome	1	0.910	-	-
SonicParanoid	1	1.000	-	-		X3818
SwiftOrtho	1	1.000	-	-
TreeFam	1	0.960	-	-
	13	12.830