DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment inaE and Daglb

DIOPT Version :9

Sequence 1:	NP_001138195.1	Gene:	inaE / 32343	FlyBaseID:	FBgn0261244	Length:	1318	Species:	Drosophila melanogaster
Sequence 2:	NP_659164.2	Gene:	Daglb / 231871	MGIID:	2442032	Length:	669	Species:	Mus musculus

Alignment Length:	711	Identity:	241/711 - (33%)
Similarity:	376/711 - (52%)	Gaps:	81/711 - (11%)

- Green bases have known domain annotations that are detailed below.

  Fly     1 MPGLVVFRRRWSVGSDDLVVPGAFLLTIHFICFVIVSVSLVIFEYNTRILSVK---LLFYHLIGY 62
            |||:|:|.||||:.|||||.||:|.|.:..:.::   |||.::..:.|.|...   ||..:||..
Mouse     1 MPGMVLFGRRWSLASDDLVFPGSFELFLRVLWWI---VSLTLYLTHRRRLDCPGGVLLSTYLIVL 62

  Fly    63 LLILFFSICVEIGICVISMRGSILDAEARTSINIWIYLKSLVILFDIAWLAVGSVWLGHYYTTAP 127
            |::|...||..:.|..:||||:|.:...|.|::..:|::..:.|.::.|.::|:.|:     ...
Mouse    63 LVLLAVIICTVLAIVCVSMRGTICNPGPRKSMSKLLYIRLALFLPEMVWASLGAAWV-----AKG 122

  Fly   128 IDDPKKVYIAII---ICNWALVVITLITIWCTFDAAGRSWVKMKKYQRSMRETESRFNYKRSNSM 189
            |...:.|.|.||   |.:|.::..|::||...||..|.   ||..|...:.|      :..|||.
Mouse   123 IQCDRTVVIGIIATVIVSWIVIAATMVTIIFVFDPLGG---KMAPYPPCIPE------HLDSNSS 178

  Fly   190 NRNWRQRKVMRAYQDSWDHRCRLLFCCMGSSERNRNSFTDIARLLSDFFRELDVVPSDVVAGLVL 254
            ||.....|.  |.:..|:.|.:...||:|..:..|.:|:..|.|.|.:|.:.|:||||:.||..|
Mouse   179 NRLLTGLKT--AAKSVWETRVQFCCCCVGQDDNTRVAFSSTADLFSTYFSDTDLVPSDIAAGFTL 241

  Fly   255 LRKFQRLEREAIVRQRKNGTYEFLSGVP-ITERTQFLALNDAKNYDFFQTVIHYMYFAQGAYGWP 318
            |.:    :::.|...|:  ..|.::..| ..:.|:.    ||:    .:...|||.||..|||||
Mouse   242 LHQ----QQDNISHSRE--PPEVVTHTPGQPQETEL----DAE----VENCHHYMPFAAAAYGWP 292

  Fly   319 MYVIINRSKMWHLVPELKCFGCCCGTSD-DTEVIQDNCCLCNYAALKKTLQLGDIDIVYATYHVD 382
            :|:..|     ......:..|.||...| :.:.::.:...|::|::.||..|...|.::.::|..
Mouse   293 LYIYRN-----PFTGLCRIGGDCCRARDIEYDAVEGDQHNCHFASILKTTGLQYRDFIHISFHDK 352

  Fly   383 VGETPFFVAIDYTHRAVVISIRGTLSMKDILTDLNAEGEVLPLQPPRDDWLGHKGMVQAAIYIRN 447
            |.|.||.|.:|:...:||:::|||:|::|:||||:||.|.|.|.....|.:.|||:.|||.||..
Mouse   353 VYELPFIVVLDHRKESVVVAVRGTMSLQDVLTDLSAESETLELGIELQDCVAHKGIAQAARYIHR 417

  Fly   448 KLQEENLIERALQRNPDRQTHTFDLVLVGHSLGAGTAAILAILLKPEHPTLQCFSYSPPGGLLSM 512
            :|..:.::.:|....|:     :.|||||||||||.||:|||:|:..:|.::.:::|||.||||.
Mouse   418 RLVNDGILSQAFSVAPE-----YQLVLVGHSLGAGAAALLAIMLRGAYPQVRAYAFSPPRGLLSK 477

  Fly   513 PAVEYSKSFITSVVLGKDVVPRIGLNQMEALRADLINAIQRSVDPKWKTI--SCSVICCGCGPE- 574
            ...||||.|:.|::||.||:||:.:..||.|:..::..|.....||:|.:  .|.....|..|:
Mouse   478 SLYEYSKDFVVSLILGMDVIPRLSVTNMEDLKRRILRVIANCNKPKYKILLHGCWYGLFGGSPDN 542

  Fly   575 -PTSVVN---------MSGQDTHINQYQEERGTARSTSAHPTDSSIALTLHQPLYPPGRIIHIVR 629
             ||.:..         :.|:.|.:.:|..  |...|.|  |.||.   |.:..|||||||||:
Mouse   543 FPTELDEGTQGALTQPLLGEQTLLTRYSP--GYCSSDS--PLDSP---TKYPTLYPPGRIIHL-- 598

  Fly   630 HHPKPDEQKYDSGWRNVLKNREPVYQAIWADSTDFDEVLISPVMLQDHMPDKVLAALKKVV 690
                  |::..||........:  |:|.||...:|.::||.|.||.|||||.::.||.:|:
Mouse   599 ------EEEGGSGRFGCCSAAQ--YRARWAHEAEFSKILIGPKMLIDHMPDVMIRALDRVL 651

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
inaE	NP_001138195.1	Lipase_3	300..542	CDD:238287	95/242 (39%)
Daglb	NP_659164.2	Lipase_3	274..507	CDD:238287	95/246 (39%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_KOG2088
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	1	1.000	-	-		FOG0001980
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	1	0.900	-	-		OOG6_102001
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R3340
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	5	4.740