Protein Alignment inaE and DAGLB

DIOPT Version :10

• Sequence 1: NP_001138195.1
• Gene: inaE / 32343
• FlyBaseID: FBgn0261244
• Length: 1318
• Species: Drosophila melanogaster
• Sequence 2: NP_631918.3
• Gene: DAGLB / 221955
• HGNCID: 28923
• Length: 672
• Species: Homo sapiens
• Alignment Length: 710
• Identity: 222/710 - (31%)
• Similarity: 361/710 - (50%)
• Gaps: 76/710 - (10%)

  Fly     1 MPGLVVFRRRWSVGSDDLVVPGAFLLTIHFICFVIVSVSLVIFEYNTRILSVKLLFYHLIGYLLI 65
            |||:|:|.|||::.|||||.||.|.|.:..:.::.:....::...........||..:||..:::
Human     1 MPGMVLFGRRWAIASDDLVFPGFFELVVRVLWWIGILTLYLMHRGKLDCAGGALLSSYLIVLMIL 65

  Fly    66 LFFSICVEIGICVISMRGSILDAEARTSINIWIYLKSLVILFDIAWLAVGSVWLGHYYTTAPIDD 130
            |...||....|..:||||:|.:...|.|::..:|::..:...::.|.::|:.|:..     .:..
Human    66 LAVVICTVSAIMCVSMRGTICNPGPRKSMSKLLYIRLALFFPEMVWASLGAAWVAD-----GVQC 125

  Fly   131 PKKV---YIAIIICNWALVVITLITIWCTFDAAGRSWVKMKKYQRSMRETESRFNYKRSNSMNRN 192
            .:.|   .||.::.:|.::..|:::|...||..|.   ||..|  |........::..|..:|
Human   126 DRTVVNGIIATVVVSWIIIAATVVSIIIVFDPLGG---KMAPY--SSAGPSHLDSHDSSQLLN-- 183

  Fly   193 WRQRKVMRAYQDSWDHRCRLLFCCMGSSERNRNSFTDIARLLSDFFRELDVVPSDVVAGLVLLRK 257
                .:..|....|:.|.:||.||:|..:..|.:|:..|.|.|.:|.:.|:||||:.|||.||.:
Human   184 ----GLKTAATSVWETRIKLLCCCIGKDDHTRVAFSSTAELFSTYFSDTDLVPSDIAAGLALLHQ 244

  Fly   258 FQ-----RLEREAIVRQRKNGTYEFLSGVPITERTQFLALNDAKNYDFFQTVIHYMYFAQGAYGW 317
            .|     ..|...:|......:.|              |..||:    .:...|||.||..||||
Human   245 QQDNIRNNQEPAQVVCHAPGSSQE--------------ADLDAE----LENCHHYMQFAAAAYGW 291

  Fly   318 PMYVIINRSKMWHLVPELKCFG-CCCGTSDDTEVIQDNCCLCNYAALKKTLQLGDIDIVYATYHV 381
            |:|:..|     .|....:..| ||...:.|.:::..:...|::.::..|..|...|.::.::|.
Human   292 PLYIYRN-----PLTGLCRIGGDCCRSRTTDYDLVGGDQLNCHFGSILHTTGLQYRDFIHVSFHD 351

  Fly   382 DVGETPFFVAIDYTHRAVVISIRGTLSMKDILTDLNAEGEVLPLQPPRDDWLGHKGMVQAAIYIR 446
            .|.|.||.||:|:...:||:::|||:|::|:||||:||.|||.::....|.|.|||:.|||.|:.
Human   352 KVYELPFLVALDHRKESVVVAVRGTMSLQDVLTDLSAESEVLDVECEVQDRLAHKGISQAARYVY 416

  Fly   447 NKLQEENLIERALQRNPDRQTHTFDLVLVGHSLGAGTAAILAILLKPEHPTLQCFSYSPPGGLLS 511
            .:|..:.::.:|....|:     :.||:||||||.|.||:||.:|:..:|.::|:::|||.||.|
Human   417 QRLINDGILSQAFSIAPE-----YRLVIVGHSLGGGAAALLATMLRAAYPQVRCYAFSPPRGLWS 476

  Fly   512 MPAVEYSKSFITSVVLGKDVVPRIGLNQMEALRADLINAIQRSVDPKWKTISCSVICCGCGPEPT 576
            ....|||:|||.|:||||||:||:.:..:|.|:..::..:.....||:|.:...:.....|..|.
Human   477 KALQEYSQSFIVSLVLGKDVIPRLSVTNLEDLKRRILRVVAHCNKPKYKILLHGLWYELFGGNPN 541

  Fly   577 SV-VNMSGQDTHINQYQ---EERGTARSTSAH------PTDSSIALTLHQPLYPPGRIIHIVRHH 631
            :: ..:.|.|..:....   |:....|.:.|:      |.|||   ..:.||||||||||:
Human   542 NLPTELDGGDQEVLTQPLLGEQSLLTRWSPAYSFSSDSPLDSS---PKYPPLYPPGRIIHL---- 599

  Fly   632 PKPDEQKYDSGWRNVLKNREPVYQAIWADSTDFDEVLISPVMLQDHMPDKVLAALKKVVT 691
                :::..||.........  |.|.|:...:|.::||.|.||.|||||.::.||..||:
Human   600 ----QEEGASGRFGCCSAAH--YSAKWSHEAEFSKILIGPKMLTDHMPDILMRALDSVVS 653

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
inaE	NP_001138195.1	Lipase_3	300..542	CDD:238287	94/242 (39%)
DAGLB	NP_631918.3	Lipase_3	274..507	CDD:238287	94/246 (38%)