DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment CtsB1 and Tinagl1

DIOPT Version :9

Sequence 1:	NP_001259536.2	Gene:	CtsB1 / 32341	FlyBaseID:	FBgn0030521	Length:	340	Species:	Drosophila melanogaster
Sequence 2:	NP_001161805.1	Gene:	Tinagl1 / 94242	MGIID:	2137617	Length:	466	Species:	Mus musculus

Alignment Length:	336	Identity:	108/336 - (32%)
Similarity:	159/336 - (47%)	Gaps:	43/336 - (12%)

- Green bases have known domain annotations that are detailed below.

  Fly    20 EPSLLSDEFIEVVRSKAKTWTVGRN---FDASVTEGHIRRLMGVHPDAHKFALPDKREVLGDLYV 81
            ||.|:..:.|:.:......|..|.:   :..::.||...||..:.|.:....:.:...|||...|
Mouse   137 EPCLVDPDMIKAINRGNYGWQAGNHSAFWGMTLDEGIRYRLGTIRPSSTVMNMNEIYTVLGQGEV 201

  Fly    82 NSVDELPEEFDSRKQWPNCPTIGEIRDQGSCGSCWAFGAVEAMSDRVCIHSGGKVNFHFSADDLV 146
                 ||..|::.::|||  .|.|..|||:|...|||......||||.|||.|.:....|..:|:
Mouse   202 -----LPTAFEASEKWPN--LIHEPLDQGNCAGSWAFSTAAVASDRVSIHSLGHMTPILSPQNLL 259

  Fly   147 SCCHTCGFGCNGGFPGAAWSYWTRKGIVSGGPYGSNQGCRPYEISPCEHHVNGTRPPC-----AH 206
            ||......||.||....||.:..|:|:||       ..|.|:  |..|.:.....|.|     |.
Mouse   260 SCDTHHQQGCRGGRLDGAWWFLRRRGVVS-------DNCYPF--SGREQNEASPTPRCMMHSRAM 315

  Fly   207 GGRTPKCSHVCQSGYTVDYAKDKHFGSKSYSVRRNVREIQEEIMTNGPVEGAFTVYEDLILYKDG 271
            |....:.:..|.:| .|| :.|.:..:.:|.:..:.:||.:|:|.||||:....|:||..||:.|
Mouse   316 GRGKRQATSRCPNG-QVD-SNDIYQVTPAYRLGSDEKEIMKELMENGPVQALMEVHEDFFLYQRG 378

  Fly   272 VYQH--------EHGKELGGHAIRILGWGVWGEEKIP------YWLIGNSWNTDWGDHGFFRILR 322
            :|.|        |..:..|.|:::|.|   ||||.:|      ||...|||...||:.|.|||:|
Mouse   379 IYSHTPVSQGRPEQYRRHGTHSVKITG---WGEETLPDGRTIKYWTAANSWGPWWGERGHFRIVR 440

  Fly   323 GQDHCGIESSI 333
            |.:.|.||:.:
Mouse   441 GTNECDIETFV 451

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CtsB1	NP_001259536.2	Propeptide_C1	24..64	CDD:285358	8/42 (19%)
CtsB1	NP_001259536.2	Peptidase_C1A_CathepsinB	88..336	CDD:239111	92/265 (35%)
Tinagl1	NP_001161805.1	Somatomedin_B	53..93	CDD:279385
		VWC	104..>152	CDD:302663	4/14 (29%)
		Peptidase_C1A_CathepsinB	203..454	CDD:239111	92/265 (35%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	1	0.910