Protein Alignment CtsB1 and CTSF

DIOPT Version :9

• Sequence 1: NP_001259536.2
• Gene: CtsB1 / 32341
• FlyBaseID: FBgn0030521
• Length: 340
• Species: Drosophila melanogaster
• Sequence 2: NP_003784.2
• Gene: CTSF / 8722
• HGNCID: 2531
• Length: 484
• Species: Homo sapiens
• Alignment Length: 373
• Identity: 81/373 - (21%)
• Similarity: 143/373 - (38%)
• Gaps: 96/373 - (25%)

  Fly     9 TAASVAALTSGEPSLLSDEFIEVVRSKAKTW--TVGRNFDASVTEGHIRRLMGVH--PDAHKFAL 69
            |.:||.:|.:.:|  ||.:....:.|..|.:  |..|.:: |..|...|..:.|:  ..|.|...
Human   162 TFSSVISLLNEDP--LSQDLPVKMASIFKNFVITYNRTYE-SKEEARWRLSVFVNNMVRAQKIQA 223

  Fly    70 PDK--------------REVLGDLYVNSV----------------DELPEEFDSRKQWPNCPTIG 104
            .|:              .|....:|:|::                |..|.|:|    |.:...:.
Human   224 LDRGTAQYGVTKFSDLTEEEFRTIYLNTLLRKEPGNKMKQAKSVGDLAPPEWD----WRSKGAVT 284

  Fly   105 EIRDQGSCGSCWAFGAVEAMSDRVCIHSGGKVNFHFSADDLVSCCHTCGFGCNGGFPGAAWSYWT 169
            :::|||.|||||||.....:..:..::.|..::  .|..:|:. |......|.||.|..|:|...
Human   285 KVKDQGMCGSCWAFSVTGNVEGQWFLNQGTLLS--LSEQELLD-CDKMDKACMGGLPSNAYSAIK 346

  Fly   170 RKGIVSGGPYGSNQGCRPYEISPCEHHVNGTRPPCAHGGRTPKCSHVCQSGYTVDYAKDKHFGSK 234
            ..|.:.                        |....::.|....|:...:        |.|.:.:.
Human   347 NLGGLE------------------------TEDDYSYQGHMQSCNFSAE--------KAKVYIND 379

  Fly   235 SYSVRRNVREIQEEIMTNGPVEGAFTVYEDLILYKDGVYQHEHGKE----------LGGHAIRIL 289
            |..:.:|.:::...:...||:..|...:        |:..:.||..          |..||:.::
Human   380 SVELSQNEQKLAAWLAKRGPISVAINAF--------GMQFYRHGISRPLRPLCSPWLIDHAVLLV 436

  Fly   290 GWGVWGEEKIPYWLIGNSWNTDWGDHGFFRILRGQDHCGIESSISAGL 337
            |:|  ....:|:|.|.|||.||||:.|::.:.||...||:.:..|:.:
Human   437 GYG--NRSDVPFWAIKNSWGTDWGEKGYYYLHRGSGACGVNTMASSAV 482

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
CtsB1	NP_001259536.2	Propeptide_C1	24..64	CDD:285358	10/43 (23%)
		Peptidase_C1A_CathepsinB	88..336	CDD:239111	59/257 (23%)
CTSF	NP_003784.2	Inhibitor_I29	187..243	CDD:214853	10/56 (18%)
		Peptidase_C1	271..482	CDD:278538	59/259 (23%)

Information from Original Tools

Tool	Simple Score	Weighted Score	Original Tool Information
			BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C165149674
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_COG4870
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	1	1.010	-	-		QHG53545
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	3	2.840