DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment CtsB1 and RD21A

DIOPT Version :9

Sequence 1:	NP_001259536.2	Gene:	CtsB1 / 32341	FlyBaseID:	FBgn0030521	Length:	340	Species:	Drosophila melanogaster
Sequence 2:	NP_564497.1	Gene:	RD21A / 841122	AraportID:	AT1G47128	Length:	462	Species:	Arabidopsis thaliana

Alignment Length:	258	Identity:	73/258 - (28%)
Similarity:	115/258 - (44%)	Gaps:	61/258 - (23%)

- Green bases have known domain annotations that are detailed below.

  Fly    85 DELPEEFDSRKQWPNCPTIGEIRDQGSCGSCWAF---GAVEAMSDRVCIHSGGKVNFHFSADDLV 146
            |||||..|.||:    ..:.|::|||.|||||||   ||||.::.   |.:|..:.  .|..:||
plant   135 DELPESIDWRKK----GAVAEVKDQGGCGSCWAFSTIGAVEGINQ---IVTGDLIT--LSEQELV 190

  Fly   147 SCCHTCGFGCNGGFPGAAWSYWTRKGIVSGGPYGSNQGCRPYEISPCEHHVNGTRPPCAHGGRTP 211
            .|..:...|||||....|:.:     |:..|...:::. .||:      .|:||
plant   191 DCDTSYNEGCNGGLMDYAFEF-----IIKNGGIDTDKD-YPYK------GVDGT----------- 232

  Fly   212 KCSHVCQSG--YTVDYAKDKHFGSKSYSVRRNVREIQEEIMTNGP----VEGAFTVYEDLILYKD 270
             |..:.::.  .|:|..:|    ..:||     .|..::.:.:.|    :|.....::   ||..
plant   233 -CDQIRKNAKVVTIDSYED----VPTYS-----EESLKKAVAHQPISIAIEAGGRAFQ---LYDS 284

  Fly   271 GVYQHEHGKELGGHAIRILGWGVWGEEKIPYWLIGNSWNTDWGDHGFFRILR----GQDHCGI 329
            |::....|.:| .|.:..:|:|.  |....||::.|||...||:.|:.|:.|    ....|||
plant   285 GIFDGSCGTQL-DHGVVAVGYGT--ENGKDYWIVRNSWGKSWGESGYLRMARNIASSSGKCGI 344

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CtsB1	NP_001259536.2	Propeptide_C1	24..64	CDD:285358
CtsB1	NP_001259536.2	Peptidase_C1A_CathepsinB	88..336	CDD:239111	70/255 (27%)
RD21A	NP_564497.1	Inhibitor_I29	50..107	CDD:214853
		Peptidase_C1	137..352	CDD:395062	71/256 (28%)
		GRAN	376..432	CDD:197621
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_COG4870
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
	3	2.810