DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment CtsB1 and AT1G02300

DIOPT Version :9

Sequence 1:	NP_001259536.2	Gene:	CtsB1 / 32341	FlyBaseID:	FBgn0030521	Length:	340	Species:	Drosophila melanogaster
Sequence 2:	NP_563647.1	Gene:	AT1G02300 / 839576	AraportID:	AT1G02300	Length:	379	Species:	Arabidopsis thaliana

Alignment Length:	366	Identity:	143/366 - (39%)
Similarity:	195/366 - (53%)	Gaps:	59/366 - (16%)

- Green bases have known domain annotations that are detailed below.

  Fly     2 NLLLLVATAASVAALTSGEPSLLSDEFIEVVRSKAKT-WTVGRN--FDASVTEGHIRRLMGV--H 61
            ||..:.|...|...|||   .:|.:|.::.|...... |....|  | |:.|....:||:||  .
plant    24 NLQGIAAENLSKQKLTS---LILQNEIVKEVNENPNAGWKAAFNDRF-ANATVAEFKRLLGVIQT 84

  Fly    62 PDAHKFALPDKREVLGDLYVNSVDELPEEFDSRKQWPNCPTI-----GEIRDQ------------ 109
            |......:|..|.   ||.:    :||:|||:|..|.:|.:|     |.|.:.
plant    85 PKTAYLGVPIVRH---DLSL----KLPKEFDARTAWSHCTSIRRILVGYILNNVLLWSTITLWFW 142

  Fly   110 ---GSCGSCWAFGAVEAMSDRVCIHSGGKVNFHFSADDLVSCCH-TCGFGCNGGFPGAAWSYWTR 170
               |.|||||||||||::|||.||..  .:|...||:|:::||. .||||||||||..||.|:..
plant   143 FLLGHCGSCWAFGAVESLSDRFCIKY--NLNVSLSANDVIACCGLLCGFGCNGGFPMGAWLYFKY 205

  Fly   171 KGIVSGGPYGSNQGCRPY-EISPCEHHVNGTRPPCAHGGRTPKCSHVCQSGYTVDYAKDKHFGSK 234
            .|:|:       |.|.|| :.:.|.|      |.|.....||||...|.|...: :.:.||:|..
plant   206 HGVVT-------QECDPYFDNTGCSH------PGCEPTYPTPKCERKCVSRNQL-WGESKHYGVG 256

  Fly   235 SYSVRRNVREIQEEIMTNGPVEGAFTVYEDLILYKDGVYQHEHGKELGGHAIRILGWGVW--GEE 297
            :|.:..:.::|..|:..|||||.|||||||...||.|||::..|.::||||::::|||..  ||:
plant   257 AYRINPDPQDIMAEVYKNGPVEVAFTVYEDFAHYKSGVYKYITGTKIGGHAVKLIGWGTSDDGED 321

  Fly   298 KIPYWLIGNSWNTDWGDHGFFRILRGQDHCGIESSISAGLP 338
               |||:.|.||..|||.|:|:|.||.:.||||.|:.||||
plant   322 ---YWLLANQWNRSWGDDGYFKIRRGTNECGIEQSVVAGLP 359

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CtsB1	NP_001259536.2	Propeptide_C1	24..64	CDD:285358	13/44 (30%)
CtsB1	NP_001259536.2	Peptidase_C1A_CathepsinB	88..336	CDD:239111	114/271 (42%)
AT1G02300	NP_563647.1	Propeptide_C1	43..85	CDD:311860	12/42 (29%)
AT1G02300	NP_563647.1	Peptidase_C1A_CathepsinB	104..357	CDD:239111	114/271 (42%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Domainoid	1	1.000	241	1.000	Domainoid score	I582
eggNOG	1	0.900	-	-		E1_COG4870
Hieranoid	1	1.000	-	-
Homologene	1	1.000	-	-		H37550
Inparanoid	1	1.050	254	1.000	Inparanoid score	I1013
OMA	1	1.010	-	-		QHG53545
OrthoDB	1	1.010	-	-		D865289at2759
OrthoFinder	1	1.000	-	-		FOG0001215
OrthoInspector	1	1.000	-	-		otm3264
orthoMCL	1	0.900	-	-		OOG6_101151
Panther	1	1.100	-	-	O	PTHR12411
Phylome	1	0.910	-	-
SonicParanoid	1	1.000	-	-		X1059
SwiftOrtho	1	1.000	-	-
TreeFam	1	0.960	-	-
	15	14.840