DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment CtsB1 and AT1G02305

DIOPT Version :9

Sequence 1:	NP_001259536.2	Gene:	CtsB1 / 32341	FlyBaseID:	FBgn0030521	Length:	340	Species:	Drosophila melanogaster
Sequence 2:	NP_563648.1	Gene:	AT1G02305 / 839538	AraportID:	AT1G02305	Length:	362	Species:	Arabidopsis thaliana

Alignment Length:	349	Identity:	149/349 - (42%)
Similarity:	195/349 - (55%)	Gaps:	44/349 - (12%)

- Green bases have known domain annotations that are detailed below.

  Fly     2 NLLL-LVATAASVAALTSGEPSLLSDEFIEVVRSKAKT-WTVGRN--FDASVTEGHIRRLMGVHP 62
            |||. :.|...|...|||.   :|.:|.::.|...... |....|  | |:.|....:||:||.|
plant    26 NLLQGIAAENLSKQKLTSW---ILQNEIVKEVNENPNAGWKASFNDRF-ANATVAEFKRLLGVKP 86

  Fly    63 DAHKFALPDKREVLGDLYVNSVD---ELPEEFDSRKQWPNCPTIGEIRDQGSCGSCWAFGAVEAM 124
                   ..|.|.|| :.:.|.|   :||:|||:|..|..|.:||.|.|||.|||||||||||::
plant    87 -------TPKTEFLG-VPIVSHDISLKLPKEFDARTAWSQCTSIGRILDQGHCGSCWAFGAVESL 143

  Fly   125 SDRVCIHSGGKVNFHFSADDLVSCC-HTCGFGCNGGFPGAAWSYWTRKGIVSG--GPYGSNQGCR 186
            |||.||..  .:|...|.:||::|| ..||.|||||:|.|||.|:...|:|:.  .||..|.||
plant   144 SDRFCIKY--NMNVSLSVNDLLACCGFLCGQGCNGGYPIAAWRYFKHHGVVTEECDPYFDNTGC- 205

  Fly   187 PYEISPCEHHVNGTRPPCAHGGRTPKCSHVCQSGYTVDYAKDKHFGSKSYSVRRNVREIQEEIMT 251
                         :.|.|.....||||:..|.||..: :.:.||:|..:|.||.:..:|..|:..
plant   206 -------------SHPGCEPAYPTPKCARKCVSGNQL-WRESKHYGVSAYKVRSHPDDIMAEVYK 256

  Fly   252 NGPVEGAFTVYEDLILYKDGVYQHEHGKELGGHAIRILGWGVW--GEEKIPYWLIGNSWNTDWGD 314
            |||||.|||||||...||.|||:|..|..:||||::::|||..  ||:   |||:.|.||..|||
plant   257 NGPVEVAFTVYEDFAHYKSGVYKHITGTNIGGHAVKLIGWGTSDDGED---YWLLANQWNRSWGD 318

  Fly   315 HGFFRILRGQDHCGIESSISAGLP 338
            .|:|:|.||.:.||||..:.||||
plant   319 DGYFKIRRGTNECGIEHGVVAGLP 342

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CtsB1	NP_001259536.2	Propeptide_C1	24..64	CDD:285358	13/42 (31%)
CtsB1	NP_001259536.2	Peptidase_C1A_CathepsinB	88..336	CDD:239111	117/252 (46%)
AT1G02305	NP_563648.1	Propeptide_C1	46..88	CDD:400445	13/49 (27%)
AT1G02305	NP_563648.1	Peptidase_C1A_CathepsinB	107..340	CDD:239111	117/252 (46%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Domainoid	1	1.000	241	1.000	Domainoid score	I582
eggNOG	1	0.900	-	-		E1_COG4870
Hieranoid	1	1.000	-	-
Homologene	1	1.000	-	-		H37550
Inparanoid	1	1.050	254	1.000	Inparanoid score	I1013
OMA	1	1.010	-	-		QHG53545
OrthoDB	1	1.010	-	-		D865289at2759
OrthoFinder	1	1.000	-	-		FOG0001215
OrthoInspector	1	1.000	-	-		otm3264
orthoMCL	1	0.900	-	-		OOG6_101151
Panther	1	1.100	-	-	O	PTHR12411
Phylome	1	0.910	-	-
SonicParanoid	1	1.000	-	-		X1059
SwiftOrtho	1	1.000	-	-
TreeFam	1	0.960	-	-
	15	14.840