DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment CtsB1 and XBCP3

DIOPT Version :9

Sequence 1:	NP_001259536.2	Gene:	CtsB1 / 32341	FlyBaseID:	FBgn0030521	Length:	340	Species:	Drosophila melanogaster
Sequence 2:	NP_563855.1	Gene:	XBCP3 / 837517	AraportID:	AT1G09850	Length:	437	Species:	Arabidopsis thaliana

Alignment Length:	306	Identity:	81/306 - (26%)
Similarity:	128/306 - (41%)	Gaps:	67/306 - (21%)

- Green bases have known domain annotations that are detailed below.

  Fly    38 TWTVGRNFDASVTEGHIR-RLMGVHPDAHKFALPDKREVLGDLYVNSVDELPEEFDSRKQWPNCP 101
            |:::..|..|.:|....: ..:|:...|....:..|.:.||    .|| ::|:..|.||:    .
plant    73 TYSLSLNAFADLTHHEFKASRLGLSVSAPSVIMASKGQSLG----GSV-KVPDSVDWRKK----G 128

  Fly   102 TIGEIRDQGSCGSCWAFGAVEAMSDRVCIHSGGKVNFHFSADDLVSCCHTCGFGCNGGFPGAAWS 166
            .:..::||||||:||:|.|..||.....|.:|..::  .|..:|:.|..:...|||||....|:.
plant   129 AVTNVKDQGSCGACWSFSATGAMEGINQIVTGDLIS--LSEQELIDCDKSYNAGCNGGLMDYAFE 191

  Fly   167 YWTRK-GIVSGGPYGSNQGCRPYEISPCEHHVNGTRPPCAHGGRTPKCSHVCQSGYTVDYAKDKH 230
            :..:. ||.:...|       ||:      ..:||                |:.    |..|.|.
plant   192 FVIKNHGIDTEKDY-------PYQ------ERDGT----------------CKK----DKLKQKV 223

  Fly   231 FGSKSYS-VRRNVREIQEEIMTNGPV-------EGAFTVYEDLILYKDGVYQHEHGKELGGHAIR 287
            ....||: |:.|..:...|.:...||       |.||.      ||..|::.......| .||:.
plant   224 VTIDSYAGVKSNDEKALMEAVAAQPVSVGICGSERAFQ------LYSSGIFSGPCSTSL-DHAVL 281

  Fly   288 ILGWGVWGEEKIPYWLIGNSWNTDWGDHGFFRILRGQDH----CGI 329
            |:|:|  .:..:.||::.|||...||..||..:.|..::    |||
plant   282 IVGYG--SQNGVDYWIVKNSWGKSWGMDGFMHMQRNTENSDGVCGI 325

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CtsB1	NP_001259536.2	Propeptide_C1	24..64	CDD:285358	5/26 (19%)
CtsB1	NP_001259536.2	Peptidase_C1A_CathepsinB	88..336	CDD:239111	70/255 (27%)
XBCP3	NP_563855.1	Inhibitor_I29	32..89	CDD:285458	4/15 (27%)
		Peptidase_C1	118..333	CDD:278538	70/256 (27%)
		GRAN	351..407	CDD:197621
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_COG4870
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	1	1.010	-	-		QHG53545
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	3	2.820