DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment CtsB1 and ctsw

DIOPT Version :9

Sequence 1:	NP_001259536.2	Gene:	CtsB1 / 32341	FlyBaseID:	FBgn0030521	Length:	340	Species:	Drosophila melanogaster
Sequence 2:	NP_001039033.1	Gene:	ctsw / 733785	XenbaseID:	XB-GENE-963153	Length:	303	Species:	Xenopus tropicalis

Alignment Length:	269	Identity:	70/269 - (26%)
Similarity:	107/269 - (39%)	Gaps:	83/269 - (30%)

- Green bases have known domain annotations that are detailed below.

  Fly    83 SVDELPEEFDSRKQWPNCPTIGEIRDQGSCGSCWAFGAVEAMSDRVCIHSGGKVNFHFSADDLVS 147
            |.:.||  |.:...|.....|.:.::|.:|.|||||.||..:..:..| .|..::.   ::..|.
Frog    73 SEEVLP--FPTSCDWRTQNVISKAKNQRTCHSCWAFAAVANIEAQWAI-LGQTISL---SEQQVI 131

  Fly   148 CCHTCGFGCNGGFPGAAW-SYWT---RKGIVSGGPYGSNQGCRPYEISPCEHHVNGTRPPCAHG- 207
            .|:||..||:||:   || ::.|   :.|:.|...|            |...||:.    |..|
Frog   132 DCNTCRNGCSGGY---AWDAFMTVLQQGGLTSEKSY------------PYTGHVSN----CRKGF 177

  Fly   208 --------------GRTPKCSHVCQSG---YTVDYAKDKHFGSKSYSVRRNVREIQEEIMTNGPV 255
                          ..|...|||...|   .|::.|..||:          .:.|.:.:.:|...
Frog   178 EAVGWIHDFEMLKKNETAMASHVAHKGTLTVTINKAPLKHY----------QKGIVDTLRSNCDP 232

  Fly   256 EGAFTVYEDLILYKDGVYQHEHGKELGGHAIRILGWGVWGEEKIPYWLIGNSWNTDWGDHGFFRI 320
            .           |.|             |.:.|:|:.  |..|:|.|::.|||..|||:.||||:
Frog   233 N-----------YVD-------------HVVLIVGYR--GGGKLPQWILKNSWGEDWGEKGFFRM 271

  Fly   321 LRGQDHCGI 329
            .|.::.|||
Frog   272 FRDKNACGI 280

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CtsB1	NP_001259536.2	Propeptide_C1	24..64	CDD:285358
CtsB1	NP_001259536.2	Peptidase_C1A_CathepsinB	88..336	CDD:239111	68/264 (26%)
ctsw	NP_001039033.1	Inhibitor_I29	1..53	CDD:214853
ctsw	NP_001039033.1	Peptidase_C1A	80..285	CDD:239068	66/260 (25%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	1	0.910