DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment CtsB1 and Ctsb

DIOPT Version :9

Sequence 1:	NP_001259536.2	Gene:	CtsB1 / 32341	FlyBaseID:	FBgn0030521	Length:	340	Species:	Drosophila melanogaster
Sequence 2:	NP_072119.2	Gene:	Ctsb / 64529	RGDID:	621509	Length:	339	Species:	Rattus norvegicus

Alignment Length:	330	Identity:	189/330 - (57%)
Similarity:	238/330 - (72%)	Gaps:	16/330 - (4%)

- Green bases have known domain annotations that are detailed below.

  Fly    15 ALTSG--EPSL--LSDEFIEVVRSKAKTWTVGRNFDASVTEGHIRRLMGVHPDAHKFALPDKREV 75
            ||||.  :||.  |||:.|..:..:..||..|||| .:|...::::|.|......|  ||::...
  Rat    13 ALTSAHDKPSFHPLSDDMINYINKQNTTWQAGRNF-YNVDISYLKKLCGTVLGGPK--LPERVGF 74

  Fly    76 LGDLYVNSVDELPEEFDSRKQWPNCPTIGEIRDQGSCGSCWAFGAVEAMSDRVCIHSGGKVNFHF 140
            ..|:      .|||.||:|:||.|||||.:||||||||||||||||||||||:|||:.|:||...
  Rat    75 SEDI------NLPESFDAREQWSNCPTIAQIRDQGSCGSCWAFGAVEAMSDRICIHTNGRVNVEV 133

  Fly   141 SADDLVSCCH-TCGFGCNGGFPGAAWSYWTRKGIVSGGPYGSNQGCRPYEISPCEHHVNGTRPPC 204
            ||:||::||. .||.|||||:|..||::|||||:||||.|.|:.||.||.|.||||||||:||||
  Rat   134 SAEDLLTCCGIQCGDGCNGGYPSGAWNFWTRKGLVSGGVYNSHIGCLPYTIPPCEHHVNGSRPPC 198

  Fly   205 AHGGRTPKCSHVCQSGYTVDYAKDKHFGSKSYSVRRNVREIQEEIMTNGPVEGAFTVYEDLILYK 269
            ...|.||||:.:|::||:..|.:|||:|..||||..:.:||..||..||||||||||:.|.:.||
  Rat   199 TGEGDTPKCNKMCEAGYSTSYKEDKHYGYTSYSVSDSEKEIMAEIYKNGPVEGAFTVFSDFLTYK 263

  Fly   270 DGVYQHEHGKELGGHAIRILGWGVWGEEKIPYWLIGNSWNTDWGDHGFFRILRGQDHCGIESSIS 334
            .|||:||.|..:|||||||||||:  |..:||||:.||||.||||:|||:||||::||||||.|.
  Rat   264 SGVYKHEAGDVMGGHAIRILGWGI--ENGVPYWLVANSWNVDWGDNGFFKILRGENHCGIESEIV 326

  Fly   335 AGLPK 339
            ||:|:
  Rat   327 AGIPR 331

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CtsB1	NP_001259536.2	Propeptide_C1	24..64	CDD:285358	13/39 (33%)
CtsB1	NP_001259536.2	Peptidase_C1A_CathepsinB	88..336	CDD:239111	162/248 (65%)
Ctsb	NP_072119.2	Propeptide_C1	26..65	CDD:285358	13/39 (33%)
Ctsb	NP_072119.2	Peptidase_C1A_CathepsinB	81..328	CDD:239111	162/248 (65%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	1	1.000	381	1.000	Domainoid score	I807
eggNOG	1	0.900	-	-		E1_COG4870
Hieranoid	1	1.000	-	-
Homologene	1	1.000	-	-		H37550
Inparanoid	1	1.050	401	1.000	Inparanoid score	I1873
OMA	1	1.010	-	-		QHG53545
OrthoDB	1	1.010	-	-		D439739at33208
OrthoFinder	1	1.000	-	-		FOG0001215
OrthoInspector	1	1.000	-	-		oto97827
orthoMCL	1	0.900	-	-		OOG6_101151
Panther	1	1.100	-	-	O	PTHR12411
Phylome	1	0.910	-	-
SonicParanoid	1	1.000	-	-		X1059
SwiftOrtho	1	1.000	-	-
TreeFam	1	0.960	-	-
	15	14.840