DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment CtsB1 and ctsbb

DIOPT Version :9

Sequence 1:	NP_001259536.2	Gene:	CtsB1 / 32341	FlyBaseID:	FBgn0030521	Length:	340	Species:	Drosophila melanogaster
Sequence 2:	XP_005160989.1	Gene:	ctsbb / 569298	ZFINID:	ZDB-GENE-070323-1	Length:	331	Species:	Danio rerio

Alignment Length:	338	Identity:	183/338 - (54%)
Similarity:	228/338 - (67%)	Gaps:	28/338 - (8%)

- Green bases have known domain annotations that are detailed below.

  Fly    12 SVAALTSGEPSL-LSDEFIEVVRSKAKTWTVGRNFDASVTEGHIRRLMGV--------HPDAHKF 67
            ::.::|...|.| ..||.|..:.:...|||.|.||| :|.:.:::.|.|.        |...|..
Zfish    13 ALLSVTCARPQLHTHDEMISFINAARSTWTAGVNFD-NVPKKYLKSLCGTVLKGPRLPHTVKHST 76

  Fly    68 ALPDKREVLGDLYVNSVDELPEEFDSRKQWPNCPTIGEIRDQGSCGSCWAFGAVEAMSDRVCIHS 132
            .:                :||:.||.|.|||||.|:.:|||||||||||||||||::|||:||||
Zfish    77 NV----------------KLPDSFDLRDQWPNCKTLNQIRDQGSCGSCWAFGAVESISDRICIHS 125

  Fly   133 GGKVNFHFSADDLVSCCHTCGFGCNGGFPGAAWSYWTRKGIVSGGPYGSNQGCRPYEISPCEHHV 197
            .||.:...||:||:|||..|||||:||||..||.||.|.|:|:||.|.|:.|||||.|:||||||
Zfish   126 KGKQSPEISAEDLLSCCDQCGFGCSGGFPAEAWDYWRRSGLVTGGLYNSDVGCRPYSIAPCEHHV 190

  Fly   198 NGTRPPCAHGGRTPKCSHVCQSGYTVDYAKDKHFGSKSYSVRRNVREIQEEIMTNGPVEGAFTVY 262
            |||||||:....||||:.||...|:|.|.:|||||||.|:|..:.::|..|:.||||||.|||||
Zfish   191 NGTRPPCSGEQDTPKCTGVCIPKYSVPYKQDKHFGSKVYNVPSDQQQIMTELYTNGPVEAAFTVY 255

  Fly   263 EDLILYKDGVYQHEHGKELGGHAIRILGWGVWGEEKIPYWLIGNSWNTDWGDHGFFRILRGQDHC 327
            ||..|||.|||||..|..|||||::|||||  .|...|:||:.||||:||||:|:|:||||.|.|
Zfish   256 EDFPLYKSGVYQHLTGSALGGHAVKILGWG--EENGTPFWLVANSWNSDWGDNGYFKILRGHDEC 318

  Fly   328 GIESSISAGLPKL 340
            ||||.:.||||||
Zfish   319 GIESEMVAGLPKL 331

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CtsB1	NP_001259536.2	Propeptide_C1	24..64	CDD:285358	14/47 (30%)
CtsB1	NP_001259536.2	Peptidase_C1A_CathepsinB	88..336	CDD:239111	158/247 (64%)
ctsbb	XP_005160989.1	Propeptide_C1	28..65	CDD:285358	13/37 (35%)
ctsbb	XP_005160989.1	Peptidase_C1A_CathepsinB	81..327	CDD:239111	158/247 (64%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C170590286
Domainoid	1	1.000	376	1.000	Domainoid score	I821
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	1	1.000	-	-
Homologene	0	0.000	Not matched by this tool.
Inparanoid	1	1.050	396	1.000	Inparanoid score	I1915
OMA	1	1.010	-	-		QHG53545
OrthoDB	1	1.010	-	-		D439739at33208
OrthoFinder	1	1.000	-	-		FOG0001215
OrthoInspector	1	1.000	-	-		otm25672
orthoMCL	1	0.900	-	-		OOG6_101151
Panther	1	1.100	-	-	O	PTHR12411
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	1	1.000	-	-		X1059
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
ZFIN	0	0.000	Not matched by this tool.
	13	12.910