DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment CtsB1 and Ctsf

DIOPT Version :9

Sequence 1:	NP_001259536.2	Gene:	CtsB1 / 32341	FlyBaseID:	FBgn0030521	Length:	340	Species:	Drosophila melanogaster
Sequence 2:	NP_063914.1	Gene:	Ctsf / 56464	MGIID:	1861434	Length:	462	Species:	Mus musculus

Alignment Length:	267	Identity:	65/267 - (24%)
Similarity:	111/267 - (41%)	Gaps:	62/267 - (23%)

- Green bases have known domain annotations that are detailed below.

  Fly    83 SVDEL-PEEFDSRKQWPNCPTIGEIRDQGSCGSCWAFGAVEAMSDRVCIHSGGKVNFHFSADDLV 146
            |:::| |.|:|.||:    ..:.|:::||.|||||||.....:..:..::.|..::  .|..:|:
Mouse   244 SINDLAPPEWDWRKK----GAVTEVKNQGMCGSCWAFSVTGNVEGQWFLNRGTLLS--LSEQELL 302

  Fly   147 SCCHTCGFGCNGGFPGAAW-SYWTRKGIVSGGPYGSNQGCRPYEISPCEHHVNGTRPPCAHGGRT 210
            . |......|.||.|..|: :.....|:.:...||                         :.|..
Mouse   303 D-CDKVDKACLGGLPSNAYAAIKNLGGLETEDDYG-------------------------YQGHV 341

  Fly   211 PKCSHVCQSGYTVDYAKDKHFGSKSYSVRRNVREIQEEIMTNGPVEGAFTVYEDLILYKDGVYQH 275
            ..|:...|..        |.:.:.|..:.||..:|...:...||:..|...:        |:..:
Mouse   342 QTCNFSAQMA--------KVYINDSVELSRNENKIAAWLAQKGPISVAINAF--------GMQFY 390

  Fly   276 EHG-----KELGG-----HAIRILGWGVWGEEKIPYWLIGNSWNTDWGDHGFFRILRGQDHCGIE 330
            .||     :.|..     ||:.::|:|  ....||||.|.|||.:|||:.|::.:.||...||:.
Mouse   391 RHGIAHPFRPLCSPWFIDHAVLLVGYG--NRSNIPYWAIKNSWGSDWGEEGYYYLYRGSGACGVN 453

  Fly   331 SSISAGL 337
            :..|:.:
Mouse   454 TMASSAV 460

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CtsB1	NP_001259536.2	Propeptide_C1	24..64	CDD:285358
CtsB1	NP_001259536.2	Peptidase_C1A_CathepsinB	88..336	CDD:239111	63/258 (24%)
Ctsf	NP_063914.1	Inhibitor_I29	165..221	CDD:214853
Ctsf	NP_063914.1	Peptidase_C1	249..460	CDD:278538	63/260 (24%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C167839733
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_COG4870
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	1	1.010	-	-		QHG53545
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	3	2.840