Protein Alignment CtsB and Cts8

DIOPT Version :10

• Sequence 1: NP_572920.1
• Gene: CtsB / 32341
• FlyBaseID: FBgn0030521
• Length: 340
• Species: Drosophila melanogaster
• Sequence 2: NP_062414.3
• Gene: Cts8 / 56094
• MGIID: 1860275
• Length: 333
• Species: Mus musculus
• Alignment Length: 370
• Identity: 97/370 - (26%)
• Similarity: 158/370 - (42%)
• Gaps: 90/370 - (24%)

  Fly     4 LLLVATAASVAALT-SGEPSLLSDEFIEVVRSKAKTWTVGRNFDASVTEGHIR-------RLMGV 60
            :||......||.:| |.:|| |..|:.|..|...|.:::..       ||..|       :|:..
Mouse     5 VLLAILCLGVAEVTQSSDPS-LDSEWQEWKRKFNKNYSMEE-------EGQKRAVWEENMKLVKQ 61

  Fly    61 H------------PDAHKF---ALPDKREVLGDLYV------NSVDE-----LPEEFDSRKQWPN 99
            |            .|.:.|   ...:.|::|.|:.|      .|:.:     ||:..|.||:  .
Mouse    62 HNIEYDQGKKNFTMDVNAFGDMTGEEYRKMLTDIPVPNFRKKKSIHQPIAGYLPKFVDWRKR--G 124

  Fly   100 CPTIGEIRDQGSCGSCWAFGAVEAMSDRVCIHSGGKVNFHFSADDLVSCCHTCG-FGCNGGFPGA 163
            |.|  .:::||:|.|||||.|..|:..::...:|..|  ..|..:||.|....| |||..|....
Mouse   125 CVT--PVKNQGTCNSCWAFSAAGAIEGQMFRKTGKLV--PLSTQNLVDCSRLEGNFGCFKGSTFL 185

  Fly   164 AWSY-WTRKGIVSGGPYGSNQGCRPYEISPCEHHVNGTRPPCAHGGRTPKCSHVCQSGYTVDYAK 227
            |..| |..:|:.:...|       ||:         ||...|.:        |..:|...:
Mouse   186 ALKYVWKNRGLEAESTY-------PYK---------GTDGHCRY--------HPERSAARI---- 222

  Fly   228 DKHFGSKSYS-VRRNVREIQEEIMTNGPVE-GAFTVYEDLILYKDGV-YQHEHGKELGGHAIRIL 289
                  .|:| |..:.:::...:.|.||:. |....::...||::|: |:.:....:..|::.::
Mouse   223 ------TSFSFVSNSEKDLMRAVATIGPISVGIDARHKSFRLYREGIYYEPKCSSNIINHSVLVV 281

  Fly   290 GWGVWGEEK--IPYWLIGNSWNTDWGDHGFFRILRGQ-DHCGIES 331
            |:|..|:|.  ..||||.||....||.:|:.::.||: :||||.|
Mouse   282 GYGYEGKESDGNKYWLIKNSHGEQWGMNGYMKLARGRNNHCGIAS 326

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
CtsB	NP_572920.1	Propeptide_C1	24..64	CDD:462365	10/58 (17%)
		Peptidase_C1A_CathepsinB	88..336	CDD:239111	71/252 (28%)
Cts8	NP_062414.3	Inhibitor_I29	29..87	CDD:214853	10/64 (16%)
		Peptidase_C1A	115..331	CDD:239068	71/252 (28%)