DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment CtsB1 and Cts7

DIOPT Version :9

Sequence 1:	NP_001259536.2	Gene:	CtsB1 / 32341	FlyBaseID:	FBgn0030521	Length:	340	Species:	Drosophila melanogaster
Sequence 2:	NP_001346316.1	Gene:	Cts7 / 56092	MGIID:	1860262	Length:	331	Species:	Mus musculus

Alignment Length:	256	Identity:	72/256 - (28%)
Similarity:	113/256 - (44%)	Gaps:	52/256 - (20%)

- Green bases have known domain annotations that are detailed below.

  Fly    86 ELPEEFDSRKQWPNCPTIGEIRDQGSCGSCWAFGAVEAMSDRVCIHSGGKVNFHFSADDLVSCCH 150
            ::|...|.||:....|    :|.|||||:|||| :|.|..:.......||: ...|..:|:.|..
Mouse   111 KIPPTLDWRKEGYVTP----VRRQGSCGACWAF-SVTACIEGQLFKKTGKL-IPLSVQNLMDCSV 169

  Fly   151 TCGF-GCNGGFPGAAWSYWTRKGIVSGGPYGSNQGCRPYEISPCEHHVNGTRPPCAHGGRTPKCS 214
            :.|. ||:||.|..|:.|....|.:..      :...|||                     .|..
Mouse   170 SYGTKGCDGGRPYDAFQYVKNNGGLEA------EATYPYE---------------------AKAK 207

  Fly   215 HVCQSGYTVDYAKDKHFGSKSYSVRRNVREIQEEIMTNGP----VEGAFTVYEDLILYKDGVYQH 275
            | |:........|...|    :.|.||...:.:.::|:||    ::|:...:..   |:.|:| |
Mouse   208 H-CRYRPERSVVKVNRF----FVVPRNEEALLQALVTHGPIAVAIDGSHASFHS---YRGGIY-H 263

  Fly   276 EH--GKELGGHAIRILGWGVWG--EEKIPYWLIGNSWNTDWGDHGFFRILRGQ-DHCGIES 331
            |.  .|:...|.:.::|:|..|  .|...|||:.||....||::|:.::.||| ::|||.|
Mouse   264 EPKCRKDTLDHGLLLVGYGYEGHESENRKYWLLKNSHGERWGENGYMKLPRGQNNYCGIAS 324

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CtsB1	NP_001259536.2	Propeptide_C1	24..64	CDD:285358
CtsB1	NP_001259536.2	Peptidase_C1A_CathepsinB	88..336	CDD:239111	72/254 (28%)
Cts7	NP_001346316.1	Inhibitor_I29	29..87	CDD:214853
		Nuclear localization signal. /evidence=ECO:0000269\|PubMed:18776147	33..50
		Peptidase_C1A	113..329	CDD:239068	72/254 (28%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_COG4870
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	1	1.010	-	-		QHG53545
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	3	2.820