DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment CtsB1 and ctsz

DIOPT Version :9

Sequence 1:	NP_001259536.2	Gene:	CtsB1 / 32341	FlyBaseID:	FBgn0030521	Length:	340	Species:	Drosophila melanogaster
Sequence 2:	NP_001006043.1	Gene:	ctsz / 450022	ZFINID:	ZDB-GENE-041010-139	Length:	301	Species:	Danio rerio

Alignment Length:	278	Identity:	75/278 - (26%)
Similarity:	116/278 - (41%)	Gaps:	50/278 - (17%)

- Green bases have known domain annotations that are detailed below.

  Fly    83 SVDELPEEFDSRKQWPNCPTIGEI---RDQ---GSCGSCWAFGAVEAMSDRVCI-HSGGKVNFHF 140
            ::.|||:|:|    |.|...:..:   |:|   ..||||||.|:..|::||:.| ......:.:.
Zfish    50 NLKELPKEWD----WRNIKGVNYVSTTRNQHIPQYCGSCWAHGSTSALADRINIKRKAAWPSAYL 110

  Fly   141 SADDLVSCCHTCGFGCNGGFPGAAWSYWTRKGI---VSGGPYGSNQGCRPYEISPCEHHVNGTRP 202
            |..:::. |...| .|:||.....|.|...|||   ........:|.|:|:  :.|     ||
Zfish   111 SVQNVID-CGDAG-SCSGGDHSGVWEYAHNKGIPDETCNNYQAKDQDCKPF--NQC-----GT-- 164

  Fly   203 PCAHGGRTPKCSHVCQSGYTVDYAKDKHFGSKSYSVRRNVREIQEEIMTNGPVEGAFTVYEDLIL 267
             |...|       ||.........|...:||.|     .:.:::.||.:.||:.......:.|..
Zfish   165 -CTTFG-------VCNIVKNFTLWKVGDYGSAS-----GLDKMKAEIYSGGPISCGIMATDKLDA 216

  Fly   268 YKDGVYQHEHGKELGGHAIRILGWGVWGEEKIPYWLIGNSWNTDWGDHGFFRILR--------GQ 324
            |..|:|.....:....|.:.:.|||| .|..:.:|::.|||...||:.|:.||:.        .|
Zfish   217 YTGGLYSEYVQEPYINHIVSVAGWGV-DENGVEFWVVRNSWGEPWGEKGWLRIVTSAYKGGSGSQ 280

  Fly   325 DHCGIESSISAG---LPK 339
            .:..||.....|   |||
Zfish   281 YNLAIEEDCMYGDPILPK 298

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CtsB1	NP_001259536.2	Propeptide_C1	24..64	CDD:285358
CtsB1	NP_001259536.2	Peptidase_C1A_CathepsinB	88..336	CDD:239111	69/265 (26%)
ctsz	NP_001006043.1	Peptidase_C1A_CathepsinX	54..295	CDD:239149	71/269 (26%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_COG4870
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
ZFIN	0	0.000	Not matched by this tool.
	2	1.810