DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment CtsB1 and Y71H2AM.25

DIOPT Version :9

Sequence 1:	NP_001259536.2	Gene:	CtsB1 / 32341	FlyBaseID:	FBgn0030521	Length:	340	Species:	Drosophila melanogaster
Sequence 2:	NP_001040887.1	Gene:	Y71H2AM.25 / 4363054	WormBaseID:	WBGene00044760	Length:	299	Species:	Caenorhabditis elegans

Alignment Length:	252	Identity:	67/252 - (26%)
Similarity:	99/252 - (39%)	Gaps:	47/252 - (18%)

- Green bases have known domain annotations that are detailed below.

  Fly    89 EEFDSRKQWPNCPTIGEIRDQGSCGSCWAFGAVEAMSDRVCIHSGGKVNFHFSADDLVSCCHTCG 153
            |||   ..|.:...:|.::|||.|.:..||....::.......:.|.: ..||...|:. |...|
Worm    83 EEF---LDWRDKGIVGPVKDQGKCNASHAFAISSSIESMYAKATNGSL-LSFSEQQLID-CDDHG 142

  Fly   154 F-GCNGGFPGAAWSYWTRKGIVSGGPYGSNQGCRPYEISPCEHHVNGTRPPCAHGGRTPKCSHVC 217
            | ||.......|.||:...||.:...|       ||.                 |....||
Worm   143 FKGCEEQPAINAVSYFIFHGIETEADY-------PYA-----------------GKENGKC---- 179

  Fly   218 QSGYTVDYAKDKHFGSKSYSVRRNVREIQ-EEIMTN-GPVEGAFTVYEDLILYKDGVYQHEHGKE 280
                |.|..|.|.....:..|..|  |.| :|::|| ||..........|..||.|:|.....:.
Worm   180 ----TFDSTKSKIQLKDAEFVVSN--ETQGKELVTNYGPAFFTMRAPPSLYDYKIGIYNPSIEEC 238

  Fly   281 LGGHAIR---ILGWGVWGEEKIPYWLIGNSWNTDWGDHGFFRILRGQDHCGIESSIS 334
            ...|.||   |:|:|:.|.:|  ||::..|:.|.||:.|:.::.|..:.|.:...|:
Worm   239 TSTHEIRSMVIVGYGIEGVQK--YWIVKGSFGTSWGEQGYMKLARDVNACAMADFIT 293

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CtsB1	NP_001259536.2	Propeptide_C1	24..64	CDD:285358
CtsB1	NP_001259536.2	Peptidase_C1A_CathepsinB	88..336	CDD:239111	67/252 (27%)
Y71H2AM.25	NP_001040887.1	Peptidase_C1A	84..295	CDD:239068	66/251 (26%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C160161104
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_COG4870
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	1	1.010	-	-		QHG53545
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	4	3.750