DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment CtsB1 and ctsc

DIOPT Version :9

Sequence 1:	NP_001259536.2	Gene:	CtsB1 / 32341	FlyBaseID:	FBgn0030521	Length:	340	Species:	Drosophila melanogaster
Sequence 2:	XP_012812143.2	Gene:	ctsc / 407938	XenbaseID:	XB-GENE-940480	Length:	458	Species:	Xenopus tropicalis

Alignment Length:	331	Identity:	102/331 - (30%)
Similarity:	147/331 - (44%)	Gaps:	69/331 - (20%)

- Green bases have known domain annotations that are detailed below.

  Fly    27 EFIEVVRSKAKTWTVGR--NFDASVTEGHIRRLMG------VHPDAHKFALPDKREVLGDLYVNS 83
            :|::.:....|:||...  .::....|..|||..|      :.|  ....||...:..|
Frog   169 DFVKQINEVQKSWTATAYPEYEGMTIEDLIRRAGGRNSRIPMRP--RPAPLPTDEKYQG------ 225

  Fly    84 VDELPEEFDSRKQWPNCP---TIGEIRDQGSCGSCWAFGAVEAMSDRVCIHSGGKVNFHFSADDL 145
               ||.|:|    |.|..   .:..:|:|.|||||:||.::..:..|:.|.|........|...:
Frog   226 ---LPTEWD----WRNIAGYNFVTPVRNQASCGSCYAFSSMGMLESRIQIRSQLSQKPILSPQQV 283

  Fly   146 VSCCHTCGFGCNGGFPG-AAWSYWTRKGIV--SGGPY-GSNQGCRPYEISPCEHHVNGTRPPCAH 206
            |||.: ...||.||||. .|..|.:..|||  |..|| ||:        |||
Frog   284 VSCSN-YSQGCEGGFPYLIAGKYVSDYGIVEESDLPYTGSD--------SPC------------- 326

  Fly   207 GGRTPKCSHVCQSGYTVDYAKDKHFGSKSYSVRRNVREIQEEIMTNGPVEGAFTVYEDLILYKDG 271
               |.|.|.  |..||.:|    |:....|. ..|...::.|::..||:..||.||:|.:.|:.|
Frog   327 ---TLKDSQ--QKYYTAEY----HYVGGFYG-GCNEAYMKLELVLGGPLSVAFEVYDDFMHYRSG 381

  Fly   272 VYQHE------HGKELGGHAIRILGWGVWGEEKIPYWLIGNSWNTDWGDHGFFRILRGQDHCGIE 330
            ||.|.      :..:|..||:.::|:|...:....||::.|||...||:.|:|||.||.|.|.||
Frog   382 VYHHTGLQDKFNPFQLTNHAVLLVGYGTDQQTGEKYWIVKNSWGESWGEKGYFRIRRGTDECAIE 446

  Fly   331 S-SISA 335
            | ::||
Frog   447 SIAVSA 452

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CtsB1	NP_001259536.2	Propeptide_C1	24..64	CDD:285358	10/44 (23%)
CtsB1	NP_001259536.2	Peptidase_C1A_CathepsinB	88..336	CDD:239111	88/262 (34%)
ctsc	XP_012812143.2	CathepsinC_exc	20..136	CDD:400909
ctsc	XP_012812143.2	Peptidase_C1A_CathepsinC	226..455	CDD:239112	89/263 (34%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	1	0.910