DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment CtsB1 and CG12163

DIOPT Version :9

Sequence 1:	NP_001259536.2	Gene:	CtsB1 / 32341	FlyBaseID:	FBgn0030521	Length:	340	Species:	Drosophila melanogaster
Sequence 2:	NP_730901.1	Gene:	CG12163 / 40628	FlyBaseID:	FBgn0260462	Length:	614	Species:	Drosophila melanogaster

Alignment Length:	325	Identity:	88/325 - (27%)
Similarity:	134/325 - (41%)	Gaps:	81/325 - (24%)

- Green bases have known domain annotations that are detailed below.

  Fly    27 EFIEVVRSKAKTWT-VGRNFDASVTEGHIRRLMGVHPDAHKFALPDKREVLGDLYVNSVDELPEE 90
            ||.::..|:.|..| :.:..:|..|.|.    ..|.|..|                   .|||:|
  Fly   356 EFADMTSSEYKERTGLWQRDEAKATGGS----AAVVPAYH-------------------GELPKE 397

  Fly    91 FDSRKQWPNCPTIGEIRDQGSCGSCWAFGAVEAMSDRVCIHSGGKVNFHFSADDLVSCCHTCGFG 155
            ||    |.....:.::::||||||||||.....:.....:.:|...  .||..:|:. |.|....
  Fly   398 FD----WRQKDAVTQVKNQGSCGSCWAFSVTGNIEGLYAVKTGELK--EFSEQELLD-CDTTDSA 455

  Fly   156 CNGGFPGAAWSYWTRKGI--VSGGPYGSNQGCRPYEISPCEHHVNGTRPPCAHGGRTPKCSHVCQ 218
            ||||....|:     |.|  :.|..|.:..   ||:....:.|.|.|            .|||..
  Fly   456 CNGGLMDNAY-----KAIKDIGGLEYEAEY---PYKAKKNQCHFNRT------------LSHVQV 500

  Fly   219 SGYTVDYAKDKHFGSKSYSVRRNVREIQEEIMTNGPVEGAFTVYEDLILYKDGVYQHEH------ 277
            :|: ||..|.            |...:||.::.|||:...... ..:..|:.||   .|
  Fly   501 AGF-VDLPKG------------NETAMQEWLLANGPISIGINA-NAMQFYRGGV---SHPWKALC 548

  Fly   278 GKELGGHAIRILGWGVWG----EEKIPYWLIGNSWNTDWGDHGFFRILRGQDHCGI-ESSISAGL 337
            .|:...|.:.::|:||..    .:.:|||::.|||...||:.|::|:.||.:.||: |.:.||.|
  Fly   549 SKKNLDHGVLVVGYGVSDYPNFHKTLPYWIVKNSWGPRWGEQGYYRVYRGDNTCGVSEMATSAVL 613

Fly 338 337
Fly 614 613

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CtsB1	NP_001259536.2	Propeptide_C1	24..64	CDD:285358	10/37 (27%)
CtsB1	NP_001259536.2	Peptidase_C1A_CathepsinB	88..336	CDD:239111	73/260 (28%)
CG12163	NP_730901.1	CY	194..272	CDD:298856
		Inhibitor_I29	308..365	CDD:285458	3/8 (38%)
		Peptidase_C1A	395..611	CDD:239068	72/259 (28%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C45452965
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_COG4870
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
	3	2.740