DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment CtsB1 and ctsb

DIOPT Version :9

Sequence 1:	NP_001259536.2	Gene:	CtsB1 / 32341	FlyBaseID:	FBgn0030521	Length:	340	Species:	Drosophila melanogaster
Sequence 2:	NP_989225.1	Gene:	ctsb / 394833	XenbaseID:	XB-GENE-1000505	Length:	333	Species:	Xenopus tropicalis

Alignment Length:	343	Identity:	194/343 - (56%)
Similarity:	227/343 - (66%)	Gaps:	23/343 - (6%)

- Green bases have known domain annotations that are detailed below.

  Fly     3 LLLLVATAASVAALTSGEPSLLSDEFIEVVRSKAKTWTVGRNFDASVTEGHIRRLMGVH---PDA 64
            :|..:|:.||...|....|  ||.:.:..:.....||..|.|| |:....:::||.|.|   |..
Frog     7 VLCFLASIASARHLPFFAP--LSGDMVNYINKMNTTWKAGHNF-ANADLHYVKRLCGTHLNGPQL 68

  Fly    65 HK-FALPDKREVLGDLYVNSVDELPEEFDSRKQWPNCPTIGEIRDQGSCGSCWAFGAVEAMSDRV 128
            .| |...|..            |||:.||||..|||||||.|:|||||||||||||||||:||||
Frog    69 QKRFGFADGM------------ELPDSFDSRAAWPNCPTIREVRDQGSCGSCWAFGAVEAISDRV 121

  Fly   129 CIHSGGKVNFHFSADDLVSCC-HTCGFGCNGGFPGAAWSYWTRKGIVSGGPYGSNQGCRPYEISP 192
            |:|:.||||...||:||:||| ..||.|||||:|..||.:||..|:||||.|.|:.|||||.|.|
Frog   122 CVHTNGKVNVEVSAEDLLSCCGFECGMGCNGGYPSGAWKFWTETGLVSGGLYDSHLGCRPYSIPP 186

  Fly   193 CEHHVNGTRPPC-AHGGRTPKCSHVCQSGYTVDYAKDKHFGSKSYSVRRNVREIQEEIMTNGPVE 256
            |||||||:||.| ...|.||||...|:.||...|..|||||:.||.|..:.:||..||..|||||
Frog   187 CEHHVNGSRPACKGEEGDTPKCVKQCEDGYAPVYGSDKHFGATSYGVPSSEKEIMAEIYKNGPVE 251

  Fly   257 GAFTVYEDLILYKDGVYQHEHGKELGGHAIRILGWGVWGEEKIPYWLIGNSWNTDWGDHGFFRIL 321
            |||.||.|..:||.||||||.|:|||||||:||||||  |...||||..|||||||||:|||:||
Frog   252 GAFLVYADFPMYKSGVYQHETGEELGGHAIKILGWGV--ENGTPYWLCANSWNTDWGDNGFFKIL 314

  Fly   322 RGQDHCGIESSISAGLPK 339
            ||:|||||||.|.||:||
Frog   315 RGKDHCGIESEIVAGIPK 332

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CtsB1	NP_001259536.2	Propeptide_C1	24..64	CDD:285358	13/42 (31%)
CtsB1	NP_001259536.2	Peptidase_C1A_CathepsinB	88..336	CDD:239111	166/249 (67%)
ctsb	NP_989225.1	Propeptide_C1	26..65	CDD:369701	12/39 (31%)
ctsb	NP_989225.1	Peptidase_C1A_CathepsinB	81..329	CDD:239111	166/249 (67%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	1	1.000	373	1.000	Domainoid score	I880
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	1	1.000	-	-		H37550
Inparanoid	1	1.050	396	1.000	Inparanoid score	I1908
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D439739at33208
OrthoFinder	1	1.000	-	-		FOG0001215
OrthoInspector	1	1.000	-	-		oto104518
Panther	1	1.100	-	-	O	PTHR12411
Phylome	0	0.000	Not matched by this tool.
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R2465
SonicParanoid	1	1.000	-	-		X1059
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	9	9.190