DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment CtsB1 and CG4847

DIOPT Version :9

Sequence 1:	NP_001259536.2	Gene:	CtsB1 / 32341	FlyBaseID:	FBgn0030521	Length:	340	Species:	Drosophila melanogaster
Sequence 2:	NP_725686.1	Gene:	CG4847 / 36973	FlyBaseID:	FBgn0034229	Length:	420	Species:	Drosophila melanogaster

Alignment Length:	256	Identity:	72/256 - (28%)
Similarity:	113/256 - (44%)	Gaps:	50/256 - (19%)

- Green bases have known domain annotations that are detailed below.

  Fly    87 LPEEFDSRKQWPNCPTIGEIRDQGSCGSCWAFGAVEAMSDRVCIHSGGKVNFHFSADDLVSCCHT 151
            :|:.||    |.....:..::.||:|||||||....|:.......:|...|  .|..:||.|...
  Fly   203 IPDAFD----WREHGGVTPVKFQGTCGSCWAFATTGAIEGHTFRKTGSLPN--LSEQNLVDCGPV 261

  Fly   152 CGF---GCNGGFPGAAWSY--WTRKGIVSGG--PYGSNQGCRPYEISPCEHHVNGTRPPCAHGGR 209
            ..|   ||:|||..||:.:  ..:||:...|  ||..|:|...|:         |::
  Fly   262 EDFGLNGCDGGFQEAAFCFIDEVQKGVSQEGAYPYIDNKGTCKYD---------GSK-------- 309

  Fly   210 TPKCSHVCQSGYTVDYAKDKHFGSKSYSVRRNVREIQEEIMTNGPVEGAFTVYEDLILYKDGVY- 273
                |.....|:.....||:             .::::.:.|.|||..:....|.|..|..|:|
  Fly   310 ----SGATLQGFAAIPPKDE-------------EQLKKVVATLGPVACSVNGLETLKNYAGGIYN 357

  Fly   274 QHEHGKELGGHAIRILGWGVWGEEKIPYWLIGNSWNTDWGDHGFFRILRGQDHCGIESSIS 334
            ..|..|....|:|.::|:|  .|:...||::.|||:..||:.|:||:.||:::|.|....|
  Fly   358 DDECNKGEPNHSILVVGYG--SEKGQDYWIVKNSWDDTWGEKGYFRLPRGKNYCFIAEECS 416

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CtsB1	NP_001259536.2	Propeptide_C1	24..64	CDD:285358
CtsB1	NP_001259536.2	Peptidase_C1A_CathepsinB	88..336	CDD:239111	72/255 (28%)
CG4847	NP_725686.1	Inhibitor_I29	112..172	CDD:285458
CG4847	NP_725686.1	Peptidase_C1A	204..418	CDD:239068	72/255 (28%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C45452945
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_COG4870
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
	3	2.740