DRSC/TRiP Functional Genomics Resources

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Protein Alignment CtsB1 and Ctsm

DIOPT Version :9

Sequence 1:NP_001259536.2 Gene:CtsB1 / 32341 FlyBaseID:FBgn0030521 Length:340 Species:Drosophila melanogaster
Sequence 2:NP_852043.2 Gene:Ctsm / 306720 RGDID:631420 Length:333 Species:Rattus norvegicus


Alignment Length:305 Identity:71/305 - (23%)
Similarity:113/305 - (37%) Gaps:91/305 - (29%)


- Green bases have known domain annotations that are detailed below.


  Fly    65 HKFALPDKREVLGDLYVNS----VDELP------EEFDSRKQWPNCPT---------IGEIRDQG 110
            |.|.:  :....||:.:..    :.|:|      |....::|..|.|.         :..:|.||
  Rat    71 HGFTM--EMNAFGDMTIEEFRKLMIEIPIPTVKKENSVQKRQAVNVPNFINWRKRGYVTPVRRQG 133

  Fly   111 SCGSCWAFGAVEAMSDRVCIHSGGKVNFHFSADDLVSCCHTCG-FGC--------------NGGF 160
            .|..||||....|:..::...:|..:  ..|..:||.|....| .||              |||.
  Rat   134 RCNVCWAFSVAGAIEGQMFQKTGQLI--PLSVQNLVDCSRPQGNLGCYLGNTYLALQYVKENGGL 196

  Fly   161 PGAAWSYWTRKGIVSGGPYGSNQGCRPYEISPCEHHVNGTRPPCAHGGRTPKCSHVCQSGYTVDY 225
            ...| :|          ||...:|       .|.:|.:.:.....                    
  Rat   197 ESEA-TY----------PYEEKEG-------SCRYHPDNSTASIT-------------------- 223

  Fly   226 AKDKHFGSKSYSVRRNVREIQEEIMTNGPVEGAFTV-YEDLILYKDGVYQHEH--GKELGGHAIR 287
              |..|      |.:|...:...:.|.||:..|... :|..:.|::|:| ||.  ...:..||:.
  Rat   224 --DFEF------VPKNEDALMNAVATLGPISVAIDARHESFLFYRNGIY-HEPNCSSSVVTHAML 279

  Fly   288 ILGWGVWGEEK--IPYWLIGNSWNTDWGDHGFFRILRGQ-DHCGI 329
            ::|:|..|||.  ..||::.||....||:.|:.:|.:.| :||||
  Rat   280 LVGYGFVGEESDGRKYWILKNSMGNKWGNRGYMKIAKDQGNHCGI 324

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
CtsB1NP_001259536.2 Propeptide_C1 24..64 CDD:285358
Peptidase_C1A_CathepsinB 88..336 CDD:239111 66/278 (24%)
CtsmNP_852043.2 Inhibitor_I29 29..87 CDD:214853 4/17 (24%)
Peptidase_C1A 115..331 CDD:239068 62/259 (24%)
Blue background indicates that the domain is not in the aligned region.


Information from Original Tools:


Tool Simple Score Weighted Score Original Tool Information
BLAST Result Score Score Type Cluster ID
Compara 00.000 Not matched by this tool.
Domainoid 00.000 Not matched by this tool.
eggNOG 1 0.900 - - E1_COG4870
Hieranoid 00.000 Not matched by this tool.
Homologene 00.000 Not matched by this tool.
Inparanoid 00.000 Not matched by this tool.
OMA 1 1.010 - - QHG53545
OrthoDB 00.000 Not matched by this tool.
OrthoFinder 00.000 Not matched by this tool.
OrthoInspector 00.000 Not matched by this tool.
orthoMCL 00.000 Not matched by this tool.
Panther 00.000 Not matched by this tool.
Phylome 1 0.910 - -
SonicParanoid 00.000 Not matched by this tool.
SwiftOrtho 00.000 Not matched by this tool.
TreeFam 00.000 Not matched by this tool.
32.820

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