DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment CtsB1 and Tinag

DIOPT Version :9

Sequence 1:	NP_001259536.2	Gene:	CtsB1 / 32341	FlyBaseID:	FBgn0030521	Length:	340	Species:	Drosophila melanogaster
Sequence 2:	NP_001005549.1	Gene:	Tinag / 300846	RGDID:	1359482	Length:	475	Species:	Rattus norvegicus

Alignment Length:	340	Identity:	100/340 - (29%)
Similarity:	153/340 - (45%)	Gaps:	47/340 - (13%)

- Green bases have known domain annotations that are detailed below.

  Fly    23 LLSDEFIEVVRSKAKTWTVGRNFD----ASVTEGHIRRLMGVHPDAHKFALPDKREVLGDLYVNS 83
            |:..|.|:.:......|| .:|:.    .::.||...||..:.|.....::.:    :...|..:
  Rat   155 LVLPELIDHINKGDYGWT-AQNYSQFWGMTLEEGFKFRLGTLPPSPMLLSMNE----MTASYPRA 214

  Fly    84 VDELPEEFDSRKQWPNCPTIGEIRDQGSCGSCWAFGAVEAMSDRVCIHSGGKVNFHFSADDLVSC 148
              :|||.|.:..:||.. |.|.: ||.:|.:.|||......:||:.|.|.|:...:.|..:|:||
  Rat   215 --DLPEVFIASYKWPGW-THGPL-DQKNCAASWAFSTASVAADRIAIQSKGRYTANLSPQNLISC 275

  Fly   149 CHTCGFGCNGGFPGAAWSYWTRKGIVSGGPY-------GSNQGCRPYEISPCEHHVNGTRPPCAH 206
            |.....|||.|....||.:..::|:||...|       .:|..|.....|......:.|| ||.:
  Rat   276 CAKNRHGCNSGSIDRAWWFLRKRGLVSHACYPLFKEQSTNNNSCAMASRSDGRGKRHATR-PCPN 339

  Fly   207 GGRTPKCSHVCQSGYTVDYAKDKHFGSKSYSVRRNVREIQEEIMTNGPVEGAFTVYEDLILYKDG 271
            ........:.|               |..|.:..|..||..||:.||||:....|:||...||.|
  Rat   340 SFEKSNRIYQC---------------SPPYRISSNETEIMREIIQNGPVQAIMQVHEDFFYYKTG 389

  Fly   272 VYQH--------EHGKELGGHAIRILGWG-VWGEE--KIPYWLIGNSWNTDWGDHGFFRILRGQD 325
            :|:|        |..::|..||:::.||| :.|.:  |..:|:..|||...||::|:||||||.:
  Rat   390 IYRHVVSTNEEPEKYRKLRTHAVKLTGWGTLRGAQGKKEKFWIAANSWGKSWGENGYFRILRGVN 454

  Fly   326 HCGIESSISAGLPKL 340
            ...||..|.|...:|
  Rat   455 ESDIEKLIIAAWGQL 469

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CtsB1	NP_001259536.2	Propeptide_C1	24..64	CDD:285358	10/43 (23%)
CtsB1	NP_001259536.2	Peptidase_C1A_CathepsinB	88..336	CDD:239111	85/265 (32%)
Tinag	NP_001005549.1	Somatomedin_B	61..104	CDD:366428
Tinag	NP_001005549.1	Peptidase_C1A_CathepsinB	217..465	CDD:239111	85/265 (32%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C166343569
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
	3	2.840