DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment CtsB1 and Testin

DIOPT Version :9

Sequence 1:	NP_001259536.2	Gene:	CtsB1 / 32341	FlyBaseID:	FBgn0030521	Length:	340	Species:	Drosophila melanogaster
Sequence 2:	NP_775155.1	Gene:	Testin / 286916	RGDID:	708447	Length:	333	Species:	Rattus norvegicus

Alignment Length:	269	Identity:	61/269 - (22%)
Similarity:	103/269 - (38%)	Gaps:	74/269 - (27%)

- Green bases have known domain annotations that are detailed below.

  Fly    79 LYVNSVDELPEEFDSRKQWPNCPTIGEIRDQGSCGSCWAFGAVEAMSDRVCIHSGGKVNFHFSAD 143
            |||      |:..|    |.....:..:::||.|.|.|||.|..::..::...:...:  ..|..
  Rat   112 LYV------PKRVD----WRQLGYVTPVKNQGHCASSWAFSATGSLEGQMFRKTERLI--PLSEQ 164

  Fly   144 DLVSCC-HTCGFGCNGGFPGAAWSYWTRKGIVSGGPYGSNQGCRPYEISPCEHHVNGTRPPCAHG 207
            :|:.|. .....||:|||...|:.|           ...|.|....|..|             :.
  Rat   165 NLLDCMGSNVTHGCSGGFMQYAFQY-----------VKDNGGLATEESYP-------------YR 205

  Fly   208 GRTPKCSHVCQSGYTVDYAKDKHFGSKSYSVRRNVR------EIQEEIMTNGPV-------EGAF 259
            |:..:|.:              |..:.:.:||..|:      .:.:.:...||:       .|:|
  Rat   206 GQGRECRY--------------HAENSAANVRDFVQIPGSEEALMKAVAKVGPISVAVDASHGSF 256

  Fly   260 TVYEDLILYKDGVYQHEHGKELG-GHAIRILGWGVWGEEK--IPYWLIGNSWNTDWGDHGFFRIL 321
            .      .|..|:|.....|.:. .||:.::|:|..|||.  ..:||:.|||..:||..|:.::.
  Rat   257 Q------FYGSGIYYEPQCKRVHLNHAVLVVGYGFEGEESDGNSFWLVKNSWGEEWGMKGYMKLA 315

  Fly   322 RG-QDHCGI 329
            :. .:||||
  Rat   316 KDWSNHCGI 324

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CtsB1	NP_001259536.2	Propeptide_C1	24..64	CDD:285358
CtsB1	NP_001259536.2	Peptidase_C1A_CathepsinB	88..336	CDD:239111	58/260 (22%)
Testin	NP_775155.1	Inhibitor_I29	29..87	CDD:214853
Testin	NP_775155.1	Peptidase_C1	114..332	CDD:395062	59/267 (22%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_COG4870
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	1	1.010	-	-		QHG53545
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	3	2.820