DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment CtsB1 and TINAG

DIOPT Version :9

Sequence 1:	NP_001259536.2	Gene:	CtsB1 / 32341	FlyBaseID:	FBgn0030521	Length:	340	Species:	Drosophila melanogaster
Sequence 2:	NP_055279.3	Gene:	TINAG / 27283	HGNCID:	14599	Length:	476	Species:	Homo sapiens

Alignment Length:	350	Identity:	105/350 - (30%)
Similarity:	153/350 - (43%)	Gaps:	66/350 - (18%)

- Green bases have known domain annotations that are detailed below.

  Fly    23 LLSDEFIEVVRSKAKTWTVGRNFD----ASVTEGHIRRLMGVHPDAHKFALPDKREVLGDLYVNS 83
            |:..|.||.|......|| .:|:.    .::.:|...||..:.|..   .|....|:...|  .:
Human   155 LVRSELIEQVNKGDYGWT-AQNYSQFWGMTLEDGFKFRLGTLPPSP---MLLSMNEMTASL--PA 213

  Fly    84 VDELPEEFDSRKQWPNCPTIGEIRDQGSCGSCWAFGAVEAMSDRVCIHSGGKVNFHFSADDLVSC 148
            ..:|||.|.:..:||.. |.|.: ||.:|.:.|||......:||:.|.|.|:...:.|..:|:||
Human   214 TTDLPEFFVASYKWPGW-THGPL-DQKNCAASWAFSTASVAADRIAIQSKGRYTANLSPQNLISC 276

  Fly   149 CHTCGFGCNGGFPGAAWSYWTRKGIVSGGPY-------GSNQGC----------RPYEISPCEHH 196
            |.....|||.|....||.|..::|:||...|       .:|.||          :.:...||.::
Human   277 CAKNRHGCNSGSIDRAWWYLRKRGLVSHACYPLFKDQNATNNGCAMASRSDGRGKRHATKPCPNN 341

  Fly   197 VNGTRPPCAHGGRTPKCSHVCQSGYTVDYAKDKHFGSKSYSVRRNVREIQEEIMTNGPVEGAFTV 261
            |.             |.:.:.|.             |..|.|..|..||.:|||.||||:....|
Human   342 VE-------------KSNRIYQC-------------SPPYRVSSNETEIMKEIMQNGPVQAIMQV 380

  Fly   262 YEDLILYKDGVYQH--------EHGKELGGHAIRILGWGVW---GEEKIPYWLIGNSWNTDWGDH 315
            .||...||.|:|:|        |..::|..||:::.|||..   ..:|..:|:..|||...||::
Human   381 REDFFHYKTGIYRHVTSTNKESEKYRKLQTHAVKLTGWGTLRGAQGQKEKFWIAANSWGKSWGEN 445

  Fly   316 GFFRILRGQDHCGIESSISAGLPKL 340
            |:||||||.:...||..|.|...:|
Human   446 GYFRILRGVNESDIEKLIIAAWGQL 470

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CtsB1	NP_001259536.2	Propeptide_C1	24..64	CDD:285358	11/43 (26%)
CtsB1	NP_001259536.2	Peptidase_C1A_CathepsinB	88..336	CDD:239111	87/275 (32%)
TINAG	NP_055279.3	Somatomedin_B	61..104	CDD:279385
		VWC	120..>154	CDD:302663
		Peptidase_C1A_CathepsinB	218..466	CDD:239111	87/275 (32%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C165149675
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	2	1.840