DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment CtsB1 and Y71H2AR.2

DIOPT Version :9

Sequence 1:	NP_001259536.2	Gene:	CtsB1 / 32341	FlyBaseID:	FBgn0030521	Length:	340	Species:	Drosophila melanogaster
Sequence 2:	NP_001367938.1	Gene:	Y71H2AR.2 / 190615	WormBaseID:	WBGene00022189	Length:	299	Species:	Caenorhabditis elegans

Alignment Length:	256	Identity:	65/256 - (25%)
Similarity:	99/256 - (38%)	Gaps:	45/256 - (17%)

- Green bases have known domain annotations that are detailed below.

  Fly    84 VDELPEEFDSRKQWPNCPTIGEIRDQGSCGSCWAFGAVEAMSDRVCIHSGGKVNFHFSADDLVSC 148
            :|...|||   ..|.....:|.::|||.|.:..||....::.......:.|.: ..||...|:.|
Worm    78 MDRTTEEF---LDWREKGIVGPVKDQGKCNASHAFAITSSIESMYAKATNGTL-LSFSEQQLIDC 138

  Fly   149 CHTCGFGCNGGFPGAAWSYWTRKGIVSGGPYGSNQGCRPYEISPCEHHVNGTRPPCAHGGRTPKC 213
            ......||...|...|..|....||.:...|       ||        |:.|...|
Worm   139 NDQGYKGCEEQFAMNAIGYLATHGIETEADY-------PY--------VDKTNEKC--------- 179

  Fly   214 SHVCQSGYTVDYAKDKHFGSKSYSVRRNVREIQEEI-MTN-GPVEGAFTVYEDLILYKDGVYQHE 276
                    |.|..|.|....|......|  |:..:: :|| ||..........|..||.|:|...
Worm   180 --------TFDSTKSKIHLKKGVVAEGN--EVLGKVYVTNYGPAFFTMRAPPSLYDYKIGIYNPS 234

  Fly   277 HGKELGGHAIR---ILGWGVWGEEKIPYWLIGNSWNTDWGDHGFFRILRGQDHCGIESSIS 334
            ..:....|.||   |:|:|:.||:|  ||::..|:.|.||:.|:.::.|..:.|.:.::|:
Worm   235 IEECTSTHEIRSMVIVGYGIEGEQK--YWIVKGSFGTSWGEQGYMKLARDVNACAMATTIA 293

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CtsB1	NP_001259536.2	Propeptide_C1	24..64	CDD:285358
CtsB1	NP_001259536.2	Peptidase_C1A_CathepsinB	88..336	CDD:239111	64/252 (25%)
Y71H2AR.2	NP_001367938.1	Peptidase_C1A	84..290	CDD:239068	62/245 (25%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C160161103
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_COG4870
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	3	2.740