DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment CtsB1 and K02E7.10

DIOPT Version :9

Sequence 1:	NP_001259536.2	Gene:	CtsB1 / 32341	FlyBaseID:	FBgn0030521	Length:	340	Species:	Drosophila melanogaster
Sequence 2:	NP_493904.1	Gene:	K02E7.10 / 186889	WormBaseID:	WBGene00019314	Length:	299	Species:	Caenorhabditis elegans

Alignment Length:	259	Identity:	58/259 - (22%)
Similarity:	95/259 - (36%)	Gaps:	74/259 - (28%)

- Green bases have known domain annotations that are detailed below.

  Fly    97 WPNCPTIGEIRDQGSCGSCWAFGAVEAMSDRVCIHSGGKVNFHFSADDLVSCCHTCGFGCNGGFP 161
            |.....:|.::|||.|.:.:||.|:.|:.......:.||: ..||...::.|.:.
Worm    86 WREKGIVGPVKDQGKCNASYAFAAIAAIESMYAKANNGKL-LSFSEQQIIDCANF---------- 139

  Fly   162 GAAWSYWTRKGIVSGGPYGSNQGCRPYEISPCEHHVN-------------GTRPPCAHGGR--TP 211
                                        .:||:.::.             ||.....:.|:  ..
Worm   140 ----------------------------TNPCQENLENVLSNRFLKENGVGTEADYPYVGKENVG 176

  Fly   212 KCSHVCQSGYTVDYAKDKHFGSKSY-SVRRNVREIQEEIMTNGPVEGAFTVYE--DLILYKDGVY 273
            ||          :|...|.....:| .|..|....:..|.|.|  .|.|.:..  ....||.|:|
Worm   177 KC----------EYDSSKMKLRPTYIDVYPNEEWARAHITTFG--TGYFRMRSPPSFFHYKTGIY 229

  Fly   274 ---QHEHGKELGGHAIRILGWGVWGEEKIPYWLIGNSWNTDWGDHGFFRILRGQDHCGIESSIS 334
               :.|.|......::.|:|:|..|.||  ||::..|:.|.||:||:.::.|..:.||:..|||
Worm   230 NPTKEECGNANEARSLAIVGYGKDGAEK--YWIVKGSFGTSWGEHGYMKLARNVNACGMAESIS 291

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CtsB1	NP_001259536.2	Propeptide_C1	24..64	CDD:285358
CtsB1	NP_001259536.2	Peptidase_C1A_CathepsinB	88..336	CDD:239111	58/259 (22%)
K02E7.10	NP_493904.1	Peptidase_C1A	82..293	CDD:239068	58/259 (22%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C160161101
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_COG4870
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	1	1.010	-	-		QHG53545
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
	4	3.840