DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment CtsB1 and cpr-9

DIOPT Version :9

Sequence 1:	NP_001259536.2	Gene:	CtsB1 / 32341	FlyBaseID:	FBgn0030521	Length:	340	Species:	Drosophila melanogaster
Sequence 2:	NP_001369965.1	Gene:	cpr-9 / 179645	WormBaseID:	WBGene00010204	Length:	351	Species:	Caenorhabditis elegans

Alignment Length:	318	Identity:	153/318 - (48%)
Similarity:	202/318 - (63%)	Gaps:	12/318 - (3%)

- Green bases have known domain annotations that are detailed below.

  Fly    27 EFIEVVRSKAKTWTVGRNFDASVTEGHIRRLMGVHPDAHKFALPDKREVLGDLYVNSVD-ELPEE 90
            :::..|::..|. .:|..| :|..:...::|||    |....:|::..|....:....| .:|:.
Worm    42 DYVNKVQTSFKA-ELGSYF-SSYPDTIKKQLMG----AKMVEIPEEYRVFEMTHPEVEDAAVPDS 100

  Fly    91 FDSRKQWPNCPTIGEIRDQGSCGSCWAFGAVEAMSDRVCIHSGGKVNFHFSADDLVSCC-HTCGF 154
            ||||..|||||:|.:||||.|||||||..|.|.:|||:||.|..|.....||||:.:|| ..||.
Worm   101 FDSRTAWPNCPSISKIRDQSSCGSCWAVSAAETISDRICIASNAKTILSISADDINACCGMVCGN 165

  Fly   155 GCNGGFPGAAWSYWTRKGIVSGGPYGSNQGCRPYEISPCEHHVNGTR-PPC-AHGGRTPKCSHVC 217
            |||||:|..||.::.:||.|:||.|....||:||...|||||||||. .|| ::...|.||...|
Worm   166 GCNGGYPIEAWRHYVKKGYVTGGSYQDKTGCKPYPYPPCEHHVNGTHYKPCPSNMYPTDKCERSC 230

  Fly   218 QSGYTVDYAKDKHFGSKSYSVRRNVREIQEEIMTNGPVEGAFTVYEDLILYKDGVYQHEHGKELG 282
            |:||.:.|.:|.|||..:|:|.:...|||:||||:||||.|||||||...|..|||.|..|..||
Worm   231 QAGYALTYQQDLHFGQSAYAVSKKAAEIQKEIMTHGPVEVAFTVYEDFEHYSGGVYVHTAGASLG 295

  Fly   283 GHAIRILGWGVWGEEKIPYWLIGNSWNTDWGDHGFFRILRGQDHCGIESSISAGLPKL 340
            |||:::|||||  :...||||..||||.|||::|:|||:||.:.||||..:..|:|||
Worm   296 GHAVKMLGWGV--DNGTPYWLCANSWNEDWGENGYFRIIRGVNECGIEGGVVGGIPKL 351

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CtsB1	NP_001259536.2	Propeptide_C1	24..64	CDD:285358	8/36 (22%)
CtsB1	NP_001259536.2	Peptidase_C1A_CathepsinB	88..336	CDD:239111	137/250 (55%)
cpr-9	NP_001369965.1	Propeptide_C1	38..74	CDD:400445	8/37 (22%)
cpr-9	NP_001369965.1	Peptidase_C1A_CathepsinB	98..338	CDD:239111	133/241 (55%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	1	1.000	320	1.000	Domainoid score	I663
eggNOG	1	0.900	-	-		E1_COG4870
Hieranoid	1	1.000	-	-
Homologene	0	0.000	Not matched by this tool.
Inparanoid	1	1.050	331	1.000	Inparanoid score	I1432
Isobase	1	0.950	-	0	Normalized mean entropy	S2776
OMA	1	1.010	-	-		QHG53545
OrthoDB	1	1.010	-	-		D439739at33208
OrthoFinder	1	1.000	-	-		FOG0001215
OrthoInspector	1	1.000	-	-		otm14118
orthoMCL	1	0.900	-	-		OOG6_101151
Panther	1	1.100	-	-	O	PTHR12411
Phylome	1	0.910	-	-
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R2465
SonicParanoid	1	1.000	-	-		X1059
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	1	0.960	-	-
	15	14.820