DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment CtsB1 and tag-196

DIOPT Version :9

Sequence 1:	NP_001259536.2	Gene:	CtsB1 / 32341	FlyBaseID:	FBgn0030521	Length:	340	Species:	Drosophila melanogaster
Sequence 2:	NP_505215.2	Gene:	tag-196 / 179240	WormBaseID:	WBGene00007055	Length:	477	Species:	Caenorhabditis elegans

Alignment Length:	266	Identity:	71/266 - (26%)
Similarity:	119/266 - (44%)	Gaps:	52/266 - (19%)

- Green bases have known domain annotations that are detailed below.

  Fly    78 DLYVNSVDELPEEFDSRKQWPNCPTIGEIRDQGSCGSCWAFGAVEAMSDRVCIHSGGKVNFHFSA 142
            |:.:|. ::|||.||    |.....:.::::||:|||||||.....:.....|.....|:  .|.
Worm   256 DVTINE-EDLPESFD----WREKGAVTQVKNQGNCGSCWAFSTTGNVEGAWFIAKNKLVS--LSE 313

  Fly   143 DDLVSCCHTCGFGCNGGFPGAAWSYWTRKGIVSGGPYGSNQGCRPYEISPCEHHVNGTRPPCAHG 207
            .:||. |.:...|||||.|..|:....|.|           |..|.:..|             :.
Worm   314 QELVD-CDSMDQGCNGGLPSNAYKEIIRMG-----------GLEPEDAYP-------------YD 353

  Fly   208 GRTPKCSHVCQSGYTVDYAKDKHFGSKSYSVRRNVREIQEEIMTNGPVEGAFTVYEDLILYKDGV 272
            ||...| |:.:....|       :.:.|..:..:..|:|:.::|.||:...... ..|..|:.||
Worm   354 GRGETC-HLVRKDIAV-------YINGSVELPHDEVEMQKWLVTKGPISIGLNA-NTLQFYRHGV 409

  Fly   273 YQHEHGKELG------GHAIRILGWGVWGEEKIPYWLIGNSWNTDWGDHGFFRILRGQDHCGIES 331
            .   |..::.      .|.:.|:|:|..|.:  |||::.|||..:||:.|:|::.||::.||::.
Worm   410 V---HPFKIFCEPFMLNHGVLIVGYGKDGRK--PYWIVKNSWGPNWGEAGYFKLYRGKNVCGVQE 469

  Fly   332 SISAGL 337
            ..::.|
Worm   470 MATSAL 475

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CtsB1	NP_001259536.2	Propeptide_C1	24..64	CDD:285358
CtsB1	NP_001259536.2	Peptidase_C1A_CathepsinB	88..336	CDD:239111	67/253 (26%)
tag-196	NP_505215.2	CY	23..>91	CDD:298856
		Inhibitor_I29	174..231	CDD:285458
		Peptidase_C1	264..475	CDD:278538	68/255 (27%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_COG4870
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	1	1.010	-	-		QHG53545
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	3	2.820