DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment CtsB1 and cpr-4

DIOPT Version :9

Sequence 1:	NP_001259536.2	Gene:	CtsB1 / 32341	FlyBaseID:	FBgn0030521	Length:	340	Species:	Drosophila melanogaster
Sequence 2:	NP_504682.1	Gene:	cpr-4 / 179053	WormBaseID:	WBGene00000784	Length:	335	Species:	Caenorhabditis elegans

Alignment Length:	346	Identity:	163/346 - (47%)
Similarity:	204/346 - (58%)	Gaps:	17/346 - (4%)

- Green bases have known domain annotations that are detailed below.

  Fly     1 MNLLLLVATAASVAALTSGEPSLLSDEFIEVVRSKAKTWTVGRNFDASVTEGHIRRLMG---VHP 62
            |..|:|.|..|..|.|.........:...|.|.||...|......|.:: |...:|||.   |.|
Worm     1 MKYLILAALVAVTAGLVIPLVPKTQEAITEYVNSKQSLWKAEIPKDITI-EQVKKRLMRTEFVAP 64

  Fly    63 DAHKFALPDKREVLGDLYVNSVDELPEEFDSRKQWPNCPTIGEIRDQGSCGSCWAFGAVEAMSDR 127
            ..     ||...|..|:   :.|.:|..||:|.|||||.:|..||||..|||||||.|.||.|||
Worm    65 HT-----PDVEVVKHDI---NEDTIPATFDARTQWPNCMSINNIRDQSDCGSCWAFAAAEAASDR 121

  Fly   128 VCIHSGGKVNFHFSADDLVSCCHTCGFGCNGGFPGAAWSYWTRKGIVSGGPYGSNQGCRPYEISP 192
            .||.|.|.||...||:|::|||..||:||.||:|..||.|..:.|..:||.|.:..||:||.::|
Worm   122 FCIASNGAVNTLLSAEDVLSCCSNCGYGCEGGYPINAWKYLVKSGFCTGGSYEAQFGCKPYSLAP 186

  Fly   193 CEHHV-NGTRPPCAHGG-RTPKCSHVC-QSGYTVDYAKDKHFGSKSYSVRRNVREIQEEIMTNGP 254
            |...| |.|.|.|...| .||.|.:.| ...|.|.|..||||||.:|:|.:.|.:||.||:.:||
Worm   187 CGETVGNVTWPSCPDDGYDTPACVNKCTNKNYNVAYTADKHFGSTAYAVGKKVSQIQAEIIAHGP 251

  Fly   255 VEGAFTVYEDLILYKDGVYQHEHGKELGGHAIRILGWGVWGEEKIPYWLIGNSWNTDWGDHGFFR 319
            ||.|||||||...||.|||.|..|:|||||||||||||.  :...||||:.||||.:||::|:||
Worm   252 VEAAFTVYEDFYQYKTGVYVHTTGQELGGHAIRILGWGT--DNGTPYWLVANSWNVNWGENGYFR 314

  Fly   320 ILRGQDHCGIESSISAGLPKL 340
            |:||.:.||||.::..|:||:
Worm   315 IIRGTNECGIEHAVVGGVPKV 335

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CtsB1	NP_001259536.2	Propeptide_C1	24..64	CDD:285358	12/42 (29%)
CtsB1	NP_001259536.2	Peptidase_C1A_CathepsinB	88..336	CDD:239111	136/250 (54%)
cpr-4	NP_504682.1	Peptidase_C1A_CathepsinB	82..331	CDD:239111	136/250 (54%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C160161095
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_COG4870
Hieranoid	1	1.000	-	-
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	1	1.010	-	-		QHG53545
OrthoDB	1	1.010	-	-		D439739at33208
OrthoFinder	1	1.000	-	-		FOG0001215
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	1	0.900	-	-		OOG6_101151
Panther	1	1.100	-	-	O	PTHR12411
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	1	1.000	-	-		X1059
SwiftOrtho	1	1.000	-	-
TreeFam	1	0.960	-	-
	12	11.720